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Selected publications from our lab

-   López-Otín, C., Matrisian, L. M. Emerging roles of proteases in tumour supression. Nature Rev Cancer , 7(10), 800-808 (2007) PDF
-   Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., López-Otín, C. Tissue specific autophagy alterations and incresed tumorigenesis in mice deficient in Atg4C/autophagin-3. J.Biol.Chem., 282 (25), 18573-18583 (2007) PDF 
-   Varela, I., Cadiñanos, J.,Pendás, A.M., Gutiérrez-Fernández, A., Folgueras, A.R., Sánchez, L.M., Zhou, Z., Rodríguez, F.J., Stewart, C.L., Vega, J.A., Tryggvason, K., Freije, J.M., López-Otín, C.  Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature, 437, 564-568 (2005) PDF  Supplementary information
-   Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J., Li, K., Chau, P.Y., Chen, D.J., Pei, D., Pendás, A.M., Cadiñanos, J., López-Otín, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S.E., Tryggvason, K., and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Medicine, 11, 780-785 (2005) PDF
-   The chimpanzee Sequencing and Analysis Consortium (including Puente, X.S., Velasco, G. & López-Otín, C.). Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437 , 69-87 (2005) PDF
-   Rat Genome Sequencing Project Consortium (including Puente, X.S. & López-Otín, C.) Genome sequence of the brown Norway rat yields insights into mammalian evolution. Nature, 428 , 493-521 (2004) PDF
-   Balbín, M., Fueyo, A., Tester, A.M., Pendás, A.M., Pitiot, A.S., Astudillo, A., Overall, C.M., Shapiro, S.D. & López-Otín, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet 35, 252-257 (2003) PDF
-   Puente, X.S., Sánchez, L.M., Overall, C. & López-Otín, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet 4, 544-558 (2003) PDF Supplementary Material
-   Cal, S., Quesada, V., Garabaya, C. & López-Otín, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci USA 100, 9185-90 (2003) PDF
-   Pendás, A.M. et al. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet 31, 94-9 (2002) PDF
-   López-Otín, C. & Overall, C.M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol 3, 509-19 (2002) PDF
-   Overall, C.M. & López-Otín, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer 2, 657-72 (2002) PDF
-   Freije, J. M., Diez-Itza, I., Balbín, M., Sánchez, L. M., Blasco, R., Tolivia, J., López-Otín, C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J. Biol. Chem 269, 16766-16773 (1994) PDF

Recent publications from our lab

2008

2007
-   Llamazares, M., Obaya, A. J., Moncada-Pazos, A., Heljasvaara, R., Espada, J., López-Otín, C., Cal, S. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci , 120(20), 3544-3552 (2007) PDF
-   López-Otín, C., Matrisian, L. M. Emerging roles of proteases in tumour supression. Nature Rev Cancer , 7(10), 800-808 (2007) PDF
-   Van Roy, M., Van Lint, P., Van Laere, I., Wielockx, B., Wilson, C., López-Otín, C., Shapiro, S., Libert,C. Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFN{gamma} based cancer therapy in mice. Mol Cancer Ther , 6(9), 2563-2571 (2007) PDF
-   Cal, S., Moncada-Pazos, A., López-Otín, C. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. Front Biosci. , 12, 4661-4669 (2007) PDF
-   Mariño, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., López-Otín, C. Tissue specific autophagy alterations and incresed tumorigenesis in mice deficient in Atg4C/autophagin-3. J.Biol.Chem., 282 (25), 18573-18583 (2007) PDF  
-   Gutiérrez-Fernández, A., Inada, M., Balbín, M., Fueyo, A., Pitiot, A.S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S.D., Noël, A., Werb, Z., Krane, S.M., López-Otín, C., Puente, X.S. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). Faseb J, 21(10), 2580-2591 (2007) PDF
-   Tester, A. M., Cox, J.H., Connor, A.R., Starr, A.E., Dean, R.A., Puente, X.S., López-Otín, C., Overall, C.M. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PloS ONE, 2(3), e312, (2007) PDF
-   Pirila, E., Korpi, J.T., Korkiamaki, T., Jahkola, T., Gutiérrez-Fernández, A., López-Otín, C., Saarialho-Kere, U., Salo, T., Sorsa, T. Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies. Wound Repair Regen., 15(1), 45-57 (2007) PDF
-   Ramírez, C.L., Cadiñanos, J., Varela, J.M., Freije, J.M.P., López-Otín, C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell. Mol. Life Sci., 64(2), 155-170 (2007) PDF

            2006
-   Hernández, M., Valenzuela, M.A., López-Otín, C. , Álvarez, J., López, J.M., Vernal, R., Gamonal, J. Matrix Metalloproteinase-13 is highly expressed in destructive periodontal disease activity. J Periodontol, 77(11), 1863-1870 (2006) PDF
-   Jost, M., Folgueras, A. R., Frerart, F., Pendás, A. M., Blacher, S., Houard, X., Berndt, S., Munaut, C., Cataldo, D., Álvarez, J., Melen-Lamalle, L., Foidart, J. M., López-Otín, C. , Noel, A. Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice. Cancer Res, 66(10), 5234-5241 (2006) PDF
-   Chabottaux, V., Sounni, N. E., Pennington, C. J., English, W. R., van den Brule, F., Blacher, S., Gilles, C., Munaut, C., Maquoi, E., López-Otín, C., Murphy, G., Edwards, D. R., Foidart, J. M., Noel, A. Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Res, 66(10), 5165-5172 (2006) PDF
-   González, L., Freije, J. M., Cal, S., López-Otín, C., Serrano, M., Palmero, I. A functional link between the tumour suppressors ARF and p33ING1. Oncogene, 25(37), 5173-5179 (2006) PDF
-   Cal, S., Peinado, J. R., Llamazares, M., Quesada, V., Moncada-Pazos, A., Garabaya, C., López-Otín, C. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. BMC Biochemistry, 7:9, (2006) PDF
-   Puente, X.S., Velasco, G., Gutiérrez-Fernández, A., Bertranpetit, J., King, M.C., López-Otín, C. Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics, 7:15, (2006) PDF
 

2005
-   Varela, I., Cadiñanos, J.,Pendás, A.M., Gutiérrez-Fernández, A., Folgueras, A.R., Sánchez, L.M., Zhou, Z., Rodríguez, F.J., Stewart, C.L., Vega, J.A., Tryggvason, K., Freije, J.M., López-Otín, C.  Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature, 437, 564-568 (2005) PDF  Supplementary information
-   The chimpanzee Sequencing and Analysis Consortium (including Puente, X.S., Velasco, G. & López-Otín, C.). Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437 , 69-87 (2005) PDF
-   Cadiñanos, J., Varela, I., López-Otín, C., Freije, J.M. From immature lamin to premature aging: Molecular pathways and therapeutic opportunities. Cell Cycle 4 (12), (2005)  PDF
-   Puente, X.S., Gutiérrez-Fernández, A., Ordóñez, G.R., Hillier, L. W., López-Otín, C. Comparative genomic analysis of human and chimpanzee proteases. Genomics, 86, 638-647 (2005) PDF
-   Díaz-Perales, A., Quesada, V., Peinado, J.R., Ugalde, A.P., Alvarez, J., Suárez, M.F., Gomis-Ruth, X., and López-Otín, C. Identification and characterization of human archaemetzincins-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea. J.Biol.Chem., 280 , 30367-30375 (2005) PDF
-   Puente, X.S., Sánchez, L.M., Gutiérrez-Fernández, A., Velasco, G., and López-Otín, C. A genomic view of the complexity of mammalian proteolytic systems. Biochem. Soc. Trans., 33, 331-334 (2005) PDF
-   Díaz-Perales, A., Quesada, V., Sánchez, L.M., Ugalde, A.P., Suárez, M.F., Fueyo, A., and López-Otín, C. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. J. Biol. Chem., 280, 14310-14317 (2005) PDF
-   Cal, S., Quesada, V. , Llamazares, M., Díaz-Perales, A., Garabaya, C., and López-Otín, C. Human polyserase-2, a novel enzyme with three tandem serine-protease domains in a single polypeptide chain. J. Biol. Chem., 280, 1953-1961 (2005) PDF
-   Van Lint, P., Wielockx, B., Puimege, L., Noël, A., López-Otín, C., Libert, C. Resistance of collagenase-2 (matrix metalloproteinase-8) deficient mice to TNF-induced lethal hepatitis. J Immunol 175 (11), 7642-7649, (2005) PDF
-   Levy, N., López-Otín, C., Hennekam, R.C. Defective prelamin A processing resulting from LMNA or ZMPSTE24 mutations as the cause of restrictive dermopathy. Arch Dermatol 141 (11), 1473-4, (2005) PDF
-   Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asashi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., López-Otín, C., Kuwaki, T., Okabe, M.,  Honke, K., Taniguchi, N. Dysregulation of TGF-ß1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci USA 102 (44), 15791-15796 (2005) PDF
-   Kennedy, A. M., Inada, M., Krane, S.M., Christie, P.T., Harding, B., López-Otín, C., Sánchez, L.M., Pannett, A.A., Dearlove, A., Hartley, C., Byrne, M.H., Reed, A.A., Nesbit, M.A., Whyte, M.P., Thakker, R.V. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO). J Clin Invest 115 (10), 2832-2842 (2005) PDF
-   Tao, Z., Peng, Y., Nolasco, L., Cal, S., López-Otín, C., Li, R., Moake, J.L., López, J.A., Dong, J.F. Role of the CUB-1 domain in docking ADAMTS-13 to unusually large Von Willebrand factor in flowing blood. Blood 106 (13), 4139-4145 (2005) PDF
-   Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J., Li, K., Chau, P.Y., Chen, D.J., Pei, D., Pendás, A.M., Cadiñanos, J., López-Otín, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S.E., Tryggvason, K., and Zhou, Z. Genomic instability in laminopathy-based premature aging. Nature Medicine, 11, 780-785 (2005) PDF
-   Gueders, M. M., Balbín, M., Rocks, N., Foidart, J.M., Gosset, P., Louis, R., Shapiro, S., Lopez-Otin, C., Noël, A., and Cataldo, D.D. Matrix Metalloproteinase-8 Deficiency Promotes Granulocytic Allergen-Induced Airway Inflammation. J Immunol, 175, 2589-2597 (2005) PDF
-   Navarro, C.L., Cadiñanos, J., De Sandre-Giovannoli, A., Bernard, R., Courrier, S., Boccaccio, I., Boyer, A., Kleijer, W.J., Wagner, A., Giuliano,F., Beemer, F.A., Freije, J.M., Cau, P., Hennekam, R.C., López-Otín, C., Badens, C., and Levy, N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive Restrictive Dermopathy and accumulation of Lamin A precursors. Hum. Mol. Genet., 14, 1503-1513 (2005) PDF
-   Appenzeller-Herzog, C., Nyfeler, B., Burkhard, P., Santamaría, I., López-Otín, C. and Hauri, H.P. Carbohydrate- and conformation-dependent cargo capture for ER-exit. Mol. Biol. Cell., 16, 1258-1267 (2005) PDF

2004         
-   Inada, M., Wang, Y., Byrne, M.H., Rahman, M.U., Miyaura, C., López-Otín, C., and Krane, S.M. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc. Natl. Acad. Sci. U.S.A., 101, 17192-17197 (2004) PDF
-   Sabeh, F., Ota, I., Holmbeck, K., Birkedal-Hansen, H., Soloway, P., Balbín, M., López-Otín, C., Shapiro, S., Inada, M., Krane, S., Allen, E., Chung, D., and Weiss, S.J. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J. Cell Biol., 167, 769-781 (2004) PDF
-   Folgueras, A.R. , Pendás, A.M. , Sánchez, L.M. , and López-Otín, C . Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int. J. Dev. Biol. ,  48, 411-424 (2004) PDF
-   Mariño, G., and López-Otín, C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell. Mol. Life Sci., 61, 1439-1454 (2004) PDF
-   Bister, V.O., Salmela, M.T., Karjalainen-Lindsberg, M.L., Uría, J., Lohi, J., Puolakkainen, P., López-Otín, C, and Saarialho-Kere, U. Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. Dig. Dis. Sci., 49, 653-661 (2004) PubMed
-   Owen, C.A., Hu, Z., López-Otín, C., and Shapiro, S.D. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J. Immunol., 172, 7791-7803 (2004) PDF
-   Overall, C.M., Tam, E.M., Kappelhoff, R., Connor, A., Ewart, T., Morrison, C.J., Puente, X.S., López-Otín, C., and Seth, A. Protease  degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibidors. Biol. Chem., 385, 493-504 (2004) PDF
-   Pendás, A.M., Folgueras, A.R., Llano, E., Caterina, J., Frerard, F., Rodríguez, F., Astudillo, A., Noel, A., Birkedal-Hansen, H., & López-Otín, C. Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol. Cell. Biol., 24, 5304-5313 (2004) PDF
-   Quesada, V., Sánchez, L.M., Álvarez, J., & López-Otín, C. Identification and characterization of human and mouse ovastacin, a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fishes. J. Biol. Chem., 279 , 26627-26634 (2004) PDF
-   Rat Genome Sequencing Project Consortium (including Puente, X.S. & López-Otín, C.) Genome sequence of the brown Norway rat yields insights into mammalian evolution. Nature, 428 , 493-521 (2004) PDF
-   Puente, X.S. & López-Otín, C. A genomic analysis of rat proteases and protease inhibitors. Genome Res., 14, 609-622 (2004) PDF
-   Rasmussen, F.H., Yeung, N., Kiefer, L., Murphy, G., López-Otín, C., Vitek, M.P., and Moss, M.L. Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. Biochemistry, 43, 2987-2995 (2004) PDF
-   Quesada, V., Díaz-Perales, A., Gutiérrez-Fernández, A., Garabaya, C., Cal, C., and López-Otín, C. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Comm 314, 54-62 (2004) PDF

2003
-   Hieta, N., Impola, U., López-Otín, C., Saarialho-Kere, U., & Kahari, V.M. Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J. Invest. Dermatol., 121, 997-1004 (2003) PubMed
-   Balbín, M., Fueyo, A., Tester, A.M., Pendás, A.M., Pitiot, A.S., Astudillo, A., Overall, C.M., Shapiro, S.D. & López-Otín, C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet 35, 252-257 (2003) PDF
-   Cadiñanos, J., Varela, I., Mandel, D.A., Schmidt, W.K., Díaz-Perales, A., López-Otín, C. & Freije, J.M. AtFACE-2, a functional prenylated-protein protease from Arabidopsis thaliana related to mammalian Ras converting enzymes. J Biol Chem 278, 42091-42097 (2003) PDF
-   Freije, J.M., Balbín. M., Pendás, A.M., Sánchez, L.M., Puente, X.S. & López-Otín, C. Matrix metalloproteases and tumor progression. Adv Exp Med Biol 532, 91-107 (2003) PDF
-   Cal, S., Quesada, V., Garabaya, C. & López-Otín, C. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci USA 100, 9185-90 (2003) PDF
-   Puente, X.S., Sánchez, L.M., Overall, C. & López-Otín, C. Human and mouse proteases: a comparative genomic approach. Nature Rev Genet 4, 544-558 (2003) PDF Supplementary Material
-   Zucker, S., Pei, D., Cao, J. & López-Otín, C. Membrane type-matrix metalloproteinases (MT-MMP). Curr Top Dev Biol 54, 1-74 (2003) PubMed
-   Llamazares, M., Cal, S., Quesada, V. & López-Otín, C. Identification and Characterization of ADAMTS-20 Defines a Novel Subfamily of Metalloproteinases-Disintegrins with Multiple Thrombospondin-1 Repeats and a Unique GON Domain. J Biol Chem 278, 13382-9 (2003) PDF
-   Cadiñanos,  J. et al.  Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Biochem J 370, 1047-54 (2003) PDF
-   Mariño,  G. et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem 278, 3671-8 (2003) PDF

2002
-   Zaragoza, C. et al. Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells. Mol Pharmacol 62, 927-35 (2002) PubMed
-   Overall, C.M. & López-Otín, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev Cancer 2, 657-72 (2002) PDF
-   Velasco, G., Cal, S., Quesada, V., Sánchez, L.M. & López-Otín, C. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem 277, 37637-46 (2002) PDF
-   López-Otín, C. & Overall, C.M. Protease degradomics: a new challenge for proteomics. Nature Rev Mol Cell Biol 3, 509-19 (2002) PDF
-   Llano, E. et al. Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. J Biol Chem 277, 23321-9 (2002) PDF
-   Pendás, A.M. et al. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nature Genet 31, 94-9 (2002) PDF
-   Cal, S. et al. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene 283, 49-62 (2002) PDF
-   Zaragoza, C., Balbín, M., López-Otín, C. & Lamas, S. Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium. Kidney Int 61, 804-8 (2002) PubMed

2001
-   Jiménez, M.J. et al. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol 155, 1333-44 (2001)PDF
-   Engelholm, L.H., Nielsen, B.S., Netzel-Arnett, S., Solberg, H. Chen, X.D. López García, J.M., López-Otín, C., Young, M.F., Birkedal-Hansen, H., Dano, K., Lund, L.R., Behrendt, N., Bugge, T.H. The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners  urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis. Lab Invest 81, 1403-14 (2001)  PDF
-   Nielsen, B.S. et al. Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to  invasive ductal carcinomas. Cancer Res 61, 7091-100 (2001) PDF
-   Cal, S., Argüelles, J.M., Fernández, P.L. & López-Otín, C. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem 276, 17932-40 (2001) PDF
-   Velasco, G. & López-Otín, C. Strategies for cloning new MMPs and TIMPs. Methods Mol Biol 151, 25-44 (2001) PubMed
-   Balbín, M. et al. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem 276, 10253-62 (2001) PDF

2000
-   Uría, J.A. & López-Otín, C. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. Cancer Res 60, 4745-51 (2000) PDF
-   Llano, E., Pendás, A.M., Aza-Blanc, P., Kornberg, T.B. & López-Otín, C. Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development. J Biol Chem 275, 35978-85 (2000) PDF
-   Stracke, J.O. et al. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. J Biol Chem 275, 14809-16 (2000) PDF
-   English, W.R. et al. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2. J Biol Chem 275, 14046-55 (2000) PDF
-   Cal, S., Freije, J.M., López, J.M., Takada, Y. & López-Otín, C. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. Mol Biol Cell 11, 1457-69 (2000) PDF

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