Calicivirus:-Rabbit hemorrhagic disease virus (RHDV).
-Rabbit vesivirus (RaV).
-Human norovirus (hNV).
Interests :
-Replication-transcription strategies.
-Gene Function.
-RNA-dependent RNA polymerase (RdRp) structure and function.
-Pathogenic mechanisms.
-Design of new vaccines and diagnostic methods.
Myxoma virus:
-Commercial vaccine strains and field isolates differentiation.
-Molecular basis of virulence.
-New diagnostic systems.
-Vaccination methods.
Interests :
-Identification, cloning and heterologous expression of genes coding for relevant antigens.
-Design of new multivalent labeled vaccines and diagnostic methods. the
-Analises of species jump determinants.
Antivirals
We use cultivable animal calicivirus, myxoma virus, human herpex virus (1 and 2) and coronavirus (HCoV-229E) for screening of antiviral compounds present in natural products or after rational desing, and eficacy studies of antiviral treatments of different types of surfaces.
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