Universidad de Oviedo. La Universidad de Asturias.
Molecular Virology and Parasitology Group
 
 
 
 
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Flecha Research team
Flecha Research interests
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Flecha Publications
 
 Contact

  Departamento de Bioquímica y Biología Molecular
Instituto Universitario de Biotecnología de Asturias
Edificio Santiago Gascón
33006 OVIEDO (SPAIN)

Teléfono: +34 985 104215
Fax: +34 985 103157

fparra@uniovi.es


 
Publications(2004-2009)
 
 The Biochemistry Dep. Building


 

Morales, M., Bárcena, J., Ramírez, M. A., Boga, J. A., Parra, F. and  Torres, J. M. (2004). Síntesis in vitro of rabbit haemorrhagic disease virus subgenomic RNA by internal initiation on  (-)-sense genomic RNA. Mapping of a subgenomic promoter.  J. Biol. Chem. 279, 17013-17018.

Ng, K.K.S., Pendás-Franco, N.,  Rojo, J., Boga, J.A., Machín, A., Martín Alonso, J.M.  and Parra, F. (2004). Crystal Structure of Norwalk Virus Polymerase Reveals the Carboxy Terminus in the Active Site Cleft. J. Biol. Chem. 279, 16638-16645.                                                        

Boga,J.A., Melón,S., Nicieza,I., de Diego,I., Villar,M., Parra, F. and de Oña, M. (2004).  Etiology of Sporadic Cases of Pediatric Acute Gastroenteritis in Asturias, Spain, and Genotyping and Characterization of Norovirus Strains Involved. J. Clin. Microbiol. 42, 2668-2674.              

Silva E, Castro A, Lopes A, Rodrigues A, Dias C, Conceicao A, Alonso J, Correia da Costa JM, Bastos M, Parra F, Moradas-Ferreira P, Silva M. (2004). A recombinant antigen recognized by Fasciola hepatica-infected hosts. J. Parasitol. 90(4), 746-51           

Martin MC, Fernandez M, Martin-Alonso JM, Parra F, Boga JA, Alvarez MA. (2004). Nisin-controlled expression of Norwalk virus VP60 protein in Lactobacillus casei. FEMS Microbiol Lett. 237(2), 385-91.

Farnós, O., Boué, O., Parra, F., Martín Alonso, J.M., Valdés, O, Joglar, M., Navea,  L., Naranjo, P., Lleonart, R. (2005). High-level expression and immunogenic properties of the recombinant rabbit hemorrhagic disease virus VP60 capsid protein obtained in Pichia pastoris. J. Biotechnol.  117, 215-224.            

Martín-Alonso, J.M., Skilling,  D.E., González-Molleda, L., del Barrio, G., Machín, A.,  Keefer, N.K., Matson,  D.O., Iversen, P.L., Smith, A.W., and Parra, F. (2005). Isolation and characterization of a new Vesivirus  from rabbits. Virology.  337, 373-383.                     

Martín Alonso, J.M., Parra, F., Castañón, S., and Ordás, R. (2006). Potato as biofactories for the production of vaccines. Ramdane Dris PhD. (ed.), ‘’Vegetables: Growing Environment and Mineral Nutrition’’, pp. 90-103.  WFL Publisher, Meri-Rastilan tie 3 C, 00980 Helsinki, Finland.

Ortín, J. and Parra, F. (2006). Structure and function of RNA replication. Annu. Rev. Microbiol. 60, 305–26.    

Farnos O, Rodriguez M, Chiong M, Parra F, Boue O, Lorenzo N, Colas M, Lleonart R. (2006). The recombinant rabbit hemorrhagic disease virus VP60 protein obtained from Pichia pastoris induces a strong humoral and cell-mediated immune response following intranasal immunization in mice. Vet Microbiol. 114, 187-195.                         

Angulo, J., Rademacher, C., Biet, T., Benie, A.J., Blume, A., Peters, H., Palcic, M., Parra, F., and Peters, T. (2006). NMR Analysis of Carbohydrate–Protein Interactions. Methods In Enzymology, 416, 12-30. 

Casais, R., Prieto, M., Balseiro, A., Solano, P.,  Parra, F., and Martín Alonso, J.M. (2007). Identification and heterologous expresión of a Sarcoptes scabiei cDNA encoding a structural antigen with immunodiagnostic potential. Vet. Res. 38, 435–450.

O. Farnós, D. Rodríguez, O. Valdés, M. Chiong, F. Parra, J. R. Toledo, E. Fernández, R. Lleonart and M. Suárez. (2007). Molecular and antigenic characterization of rabbit hemorrhagic disease virus isolated in Cuba indicates a distinct antigenic subtype. Arch.Virol. 152,1215-1221.                                

Zamyatkin, D.F., Parra, F., Martín Alonso, J.M., Harki, D.A., Peterson, B.R., Grochulski, P.,   and K.K.-S. Ng. (2008). Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J. Biol. Chem. 283,  7705-7712.                                  

Rademacher, C., N. Krishna, R., Palcic, M., Parra, F., and Peters, T. (2008). NMR Experiments Reveal the Molecular Basis of Receptor Recognition by a Calicivirus. J. Am. Chem. Soc. 130, 3669-3675.  

Casais, R., González Molleda, L.,  Machín, A.,  del Barrio, G.,  García Manso, A., Dalton, K.P. Coto, A., Martín Alonso, J.M. Prieto, M., Parra, F. (2008). Structural and functional analysis of virus factories purified from Rabbit vesivirus-infected Vero cells. Virus. Res. 137, 112-121.                   

Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA. (2008). The Fasciola hepatica thioredoxin: high resolution structure reveals two oxidation states. Mol. Biochem. Parasitol. 161, 44-48.                     

Farnos,O.; Fernandez,E.; Chiong,M.; Parra,F.; Joglar,M.; Mendez,L.; Rodriguez,E.; Moya,G.; Rodriguez,D.; Lleonart,R.; Gonzalez,E.M.; Alonso,A.; Alfonso,P.; Suarez,M.; Rodriguez,M.P.; Toledo,J.R. (2009). Biochemical and structural characterization of RHDV capsid protein variants produced in Pichia pastoris: Advantages for immunization strategies and vaccine implementation. Antivir. Res.  81,  25-36.   

Balseiro, A., Dalton,  K.P., del Cerro, A.,  Marquez, I.,  Cunningham, A.A., Parra, F., Prieto, J.M. and Casais, R. (2009). Pathology, isolation and molecular characterisation of a ranavirus from the common midwife toad Alytes obstetricans on the Iberian Peninsula. Dis. Aquat. Org. 84,  95-104.    

Álvarez, A.L., del Barrio, G., Kourí, V., Álvarez, P.A., Suárez, B. and Parra, F. (2009). In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis. Phytomedicine   En prensa. DOI: 10.1016/j.phymed.2009.03.023

Machín A, Martín Alonso JM, Dalton KP, Parra F. (2009). Functional differences between precursor and mature forms of the RdRp from rabbit hemorrhagic disease virus.  J.Gen.Virol.    In press                       

Zamyatkin, D.F., Parra, F.,  Machín, A.,  Grochulski, P. and K.K.-S. Ng. (2009). Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces rearrangement of the Active Site.  J. Mol. Biol. In press                                                                 

González-Reyes, S.,  García-Manso, A.,  del Barrio, G.,   Dalton, K.P.,  González-Molleda, L., Arrojo-Fernández, L., Nicieza, I.,  and  Parra. F. 2009. Role of annexin A2 in cellular entry of rabbit vesivirus. J. Gen. Virol. In press.


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