Molecular biology of cancer

GROUP HEAD BIOGRAPHY

Carlos Lopez-Otin is a Professor of Biochemistry and Molecular Biology, combining his teaching responsibilities with his research lines: Cancer, Aging Biology and Functional Analysis of Genomes. He has published over 400 articles and have been cited more than 50.000 times, with an aggregate Hirsch index of h=106. He is a member of numerous journal editorial boards, committees, and scientific societies, including the Spanish Royal Academy of Sciences and the European Academy. Throughout his scientific career, he has received national and international awards and distinctions, including the Doctorates “Honoris Causa” from the International University Menendez Pelayo, the University of Zaragoza and the Autonomous University of Chile, the “Rey Jaime I” Award in Research, the European “25th FEBS Jubilee” Award in Biochemistry, the Mexico Award in Science and Technology, and the “Santiago Ramón y Cajal” National Research Award. In 2017, he was awarded an “ERC Advanced Grant” from the European Union.

SELECTED PUBLICATIONS

• Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E. “Non-coding recurrent mutations in chronic lymphocytic leukaemia”Nature526: 519-524 (2015)
• Osorio FG, Soria-Valles C, Santiago-Fernández O, Bernal T, Mittelbrunn M, Colado E, Rodríguez F, Bonzon-Kulichenko E, Vázquez J, Porta-de-la-Riva M, Cerón J, Fueyo A, Li J, Green AR, Freije JM, López-Otín C. “Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling” Nature Med. 22: 91-96 (2016)
• López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. “Metabolic control of longevity” Cell 166: 802-821 (2016)
• Ferrando AA, López-Otín C. “Clonal evolution in leukemia” Nature Med. 23: 1135-1145 (2017)
• Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C. “Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome” Nature Med. 25: 423-426 (2019)
• Bárcena C, Valdés-Mas R, Mayoral P, Garabaya C, Durand S, Rodríguez F, Fernández-García MT, Salazar N, Nogacka AM, Garatachea N, Bossut N, Aprahamian F, Lucia A, Kroemer G, Freije JMP, Quirós PM, López-Otín C. “Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice” Nature Med. 25: 1234-1242 (2019)
• Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E, Stein LD. “The U1 spliceosomal RNA is recurrently mutated in multiple cancers” Nature 574: 712-716 (2019)
• ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (including Puente XS and López-Otín C, Universidad de Oviedo) “Pan-cancer analysis of whole genomes” Nature 578: 82-93 (2020)
• López-Otín C and Kroemer G. “The hallmarks of health” Cell 184: 33-63 (2021)
• Bousquets-Muñoz P, Díaz-Navarro A, Nadeu F, Sánchez-Pitiot A, López-Tamargo S, Shuai S, Balbín M, Tubio JMC, Beà S, Martin-Subero JI, Gutiérrez-Fernández A, Stein LD, Campo E, Puente XS. “PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2” NPJ Genom Med. 7:19 (2022)