Cancer Epigenetics

Unit headepi

Mario F. Fraga

Location

Avda. de la Vega, 4 – 6.
33940. El Entrego, Spain
y
Hospital Universitario Central de Asturias (HUCA)
FINBA, planta 0
Avda. de Roma, s/n.
33011-Oviedo, Spain

 

Research lines

Epigenetics has become a fundamental discipline in the study of genome biology. Cell growth and differentiation is largely regulated by epigenetic processes. The alteration of these epigenetic mechanisms is associated with numerous pathologies, notably cancer.

Diapositiva1

Currently, our research focuses on the study of locus-specific and genome-wide epigenetic mechanisms such as DNA methylation and histone post-translational modifications during cell differentiation, and their alterations in cancer and aging.

circos

 

Group head biography

Mario F. Fraga is a Tenured Scientist at the Nanomaterials and Nanotechnology Center (CINN-CSIC). He received his Ph.D. in developmental epigenetics from the University of Oviedo, and was a “Ramon y Cajal” postdoctoral fellow in the Spanish National Cancer Research Centre (CNIO), where his research was focused on cancer epigenetics and the study of inter-individual epigenetic variation. The research interests of his team are in epigenetic processes involved in cell differentiation and their alterations in cancer and aging.

 

Selected publications

  • Fernández AF, Bayón GF, Urdinguio RG, Toraño EG, García MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Bueno C, Menéndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nisticó L, Stazi MA, Fraga MF. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 2015 Jan;25(1):27-40. doi: 10.1101/gr.169011.113.
  • Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, Martinez-Camblor P, Obaya AJ, Bernal T, Parra-Blanco A, Rodrigo L, Santacana M, Matias-Guiu X, Soldevilla B, Dominguez G, Bonilla F, Cal S, Lopez-Otin C, Fraga MF. Immune dependent and independent anti-tumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res. 2013 Jan 1;73(1):395-405.
  • Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. Nat Rev Genet. 2012 Jan 4;13(2):97-109.
  • Calvanese V, Fernández AF, Urdinguio RG, Suárez-Alvarez B, Mangas C, Pérez-García V, Bueno C, Montes R, Ramos-Mejía V, Martínez-Camblor P, Ferrero C, Assenov Y, Bock C, Menendez P, Carrera AC, Lopez-Larrea C, Fraga MF.A promoter DNA demethylation landscape of human hematopoietic differentiation. Nucleic Acids Res. 2012 Jan;40(1):116-31.
  • Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13736-41. Epub 2010 Jul 14.

 

Personnel

Name Position e-mail Phone number
Mario Fernández Fraga Group leader mffraga@cinn.es 985733644 ext 218
Agustín Fernández Fernández Miguel Servet researcher affernandez@hca.es 985652411
Marta Sierra Zapico Senior researcher sierramarta@uniovi.es 985652412
Rocio González Urdinguio Senior researcher gonzalezurocio@uniovi.es 985652412
Gustavo Fernández Bayón Senior bioinformatician gbayon@gmail.com 985101768
Virginia López Martínez Postdoctoral fellow virivir@gmail.com 985652412
Juan Ramón Tejedor Vaquero Postdoctoral fellow juanramon.tejedor@gmail.com 985101768
Sandra Rodríguez Rodero Postdoctoral fellow srrodero@hca.es 985101768
Isabel Cobo Sánchez Bioinformatician icobo@carrerasresearch.org 985101768
Juan Luís Fernández Morera fernandezmorera@gmail.com 985101768
María García García Predoctoral fellow antonellacarella@gmail.com 985101768
Antonella Carella Predoctoral fellow mgg_36@hotmail.com 985101768
Cristina Mangas Alonso Technician mangascristina@uniovi.es 985101768
Thalia Belmonte García Master student thaliabelmonte@gmail.com 985101768
Pablo Santamaria Ojeda Master student pablosoov76@gmail.com 985101768
Paula Morales Sánchez Master student UO230179@uniovi.es 985101768
Raúl Fernández Pérez Master student rauldiul@gmail.com 985101768

 

 

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