{"id":1096,"date":"2021-12-22T15:16:34","date_gmt":"2021-12-22T15:16:34","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1096"},"modified":"2023-06-19T13:09:59","modified_gmt":"2023-06-19T11:09:59","slug":"estres-oxidativo","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/investigacion\/estres-oxidativo\/","title":{"rendered":"Estr\u00e9s oxidativo"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><strong>JEFAS DE UNIDAD<\/strong><br \/>\nCarmen Rodr\u00edguez S\u00e1nchez<br \/>\nVanesa Mart\u00edn Fern\u00e1ndez<\/p>\n<p><strong>LOCALIZACI\u00d3N<\/strong><\/p>\n<p>Departamento de Morfolog\u00eda y Biolog\u00eda Celular. 9\u00aa planta. Lab. 13.<br \/>\nFacultad de Medicina.\u00a0c\/ Julian Claver\u00eda 6, Oviedo.<\/p>\n<p>e-mail: <a href=\"mailto:carro@uniovi.es\">carro@uniovi.es<\/a><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"689\" height=\"320\" title=\"PIB-EstresOxid_2\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2.png\" alt class=\"lazyload img-responsive wp-image-2780\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27689%27%20height%3D%27320%27%20viewBox%3D%270%200%20689%20320%27%3E%3Crect%20width%3D%27689%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2-200x93.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2-400x186.png 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2-600x279.png 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-EstresOxid_2.png 689w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p><strong>L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/p>\n<p>En nuestro grupo estudiamos la capacidad antitumoral de antioxidantes naturales y mol\u00e9culas antitumorales de nueva s\u00edntesis cuando se administran individualmente y tambi\u00e9n su capacidad para potenciar la eficacia de la quimioterapia convencional. Estamos interesados en las v\u00edas de se\u00f1alizaci\u00f3n que median estos efectos, con la finalidad de buscar nuevos enfoques terap\u00e9uticos utilizando estas mol\u00e9culas en combinaci\u00f3n con otros f\u00e1rmacos antitumorales y\/o para usarlas en tumores particulares de forma dirigida. Adem\u00e1s de las v\u00edas cl\u00e1sicas desencadenadas por la activaci\u00f3n de los receptores de tirosina quinasa o de muerte, estamos especialmente interesados \u200b\u200ben el estudio del estado redox celular y la interdependencia de estas v\u00edas con el metabolismo tumoral, ya que su participaci\u00f3n en la iniciaci\u00f3n y progresi\u00f3n del c\u00e1ncer est\u00e1 bien establecida. Estos estudios se realizan en l\u00edneas de c\u00e9lulas tumorales disponibles comercialmente, en c\u00e9lulas tumorales de pacientes -tanto c\u00e9lulas madre tumorales como del estroma tumoral- y tambi\u00e9n en modelos animales de experimentaci\u00f3n.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>En la actualidad nos centramos en las siguientes l\u00edneas de investigaci\u00f3n espec\u00edficas:<\/p>\n<\/div><ul class=\"fusion-checklist fusion-checklist-1\" style=\"font-size:16px;line-height:27.2px;\"><li style=\"background-color:rgba(255,255,255,0);\" class=\"fusion-li-item\"><span style=\"height:27.2px;width:27.2px;margin-right:11.2px;\" class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon fa-angle-right fas\" style=\"color:#25afb4;\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\" style=\"margin-left:38.4px;color:#2f2f2f;\">\n<p>Estudio de la acci\u00f3n citot\u00f3xica de la indolamina de origen natural melatonina y de nuevos inhibidores de quinasas en el sarcoma de Ewing y tumores hematol\u00f3gicos. Estos estudios se realizan en l\u00edneas celulares comerciales y en c\u00e9lulas de pacientes. Tambi\u00e9n se realizan estudios induciendo tumores <em>in vivo<\/em> mediante la administraci\u00f3n de c\u00e9lulas tumorales transfectadas con luciferasa para su monitorizaci\u00f3n por imagen (IVIS: In Vivo Image System) en ratones inmunodeprimidos NOD\/SCID.<\/p>\n<\/div><\/li><li style=\"background-color:rgba(255,255,255,0);\" class=\"fusion-li-item\"><span style=\"height:27.2px;width:27.2px;margin-right:11.2px;\" class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon fa-angle-right fas\" style=\"color:#25afb4;\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\" style=\"margin-left:38.4px;color:#2f2f2f;\">\n<p>Evaluaci\u00f3n de la acci\u00f3n antitumoral de la melatonina y de nuevos inhibidores de quinasas en c\u00e9lulas madre y del estroma tumoral de glioblastoma humano. Los estudios se realizan en c\u00e9lulas madre y del estroma tumoral obtenidas de pacientes a trav\u00e9s del Banco de Tumores y en l\u00edneas celulares comerciales. Los experimentos <em>in vivo<\/em> se realizan mediante la implantaci\u00f3n de c\u00e9lulas madre de glioblastoma humano en el cerebro de ratones desnudos Balb\/c-nu. Este modelo proporciona una r\u00e9plica fiel del paciente tumoral en el rat\u00f3n a diferencia de los modelos experimentales en los que se implantan c\u00e9lulas de todo el tumor o l\u00edneas celulares comerciales. El seguimiento <em>in vivo<\/em> del tumor se realiza mediante resonancia magn\u00e9tica nuclear (RMN).<\/p>\n<\/div><\/li><li style=\"background-color:rgba(255,255,255,0);\" class=\"fusion-li-item\"><span style=\"height:27.2px;width:27.2px;margin-right:11.2px;\" class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon fa-angle-right fas\" style=\"color:#25afb4;\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\" style=\"margin-left:38.4px;color:#2f2f2f;\">\n<p>Estudio de la eficacia antitumoral de combinaciones de estas sustancias con quimioterapia convencional. Estos estudios son de especial inter\u00e9s en el caso de la combinaci\u00f3n de quimioterap\u00e9uticos convencionales o de nueva s\u00edntesis con melatonina (que tiene efectos secundarios poco relevantes o nulos). Se ha demostrado que la melatonina disminuye la expresi\u00f3n del transportador de f\u00e1rmacos ABCG2 en el glioblastoma humano tanto en el caso de c\u00e9lulas del estroma tumoral como de c\u00e9lulas madre tumorales, reduciendo la DL50 del quimioter\u00e1pico estudiado para ambos grupos celulares.<\/p>\n<\/div><\/li><li style=\"background-color:rgba(255,255,255,0);\" class=\"fusion-li-item\"><span style=\"height:27.2px;width:27.2px;margin-right:11.2px;\" class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon fa-angle-right fas\" style=\"color:#25afb4;\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\" style=\"margin-left:38.4px;color:#2f2f2f;\">\n<p>Estudio de las diferencias en la biolog\u00eda tumoral de varios tipos de c\u00e1ncer -especialmente en t\u00e9rminos de metabolismo basal y estado redox- y su modificaci\u00f3n tras la administraci\u00f3n de melatonina y otras mol\u00e9culas antioxidantes. Varios antioxidanes naturales como el resveratrol o la melatonina, muestran diferentes efectos antitumorales seg\u00fan el tipo de c\u00e1ncer: en la mayor\u00eda de los casos inhiben la proliferaci\u00f3n celular mientras que en algunos casos inducen muerte celular y aumento r\u00e1pido de oxidantes intracelulares. Los objetivos espec\u00edficos de estos estudios son: a) obtener informaci\u00f3n sobre cu\u00e1l podr\u00eda ser la diana y los puntos clave de la acci\u00f3n citot\u00f3xica de estos compuestos en base a las diferencias metab\u00f3licas entre grupos tumorales; b) predecir tipos de tumores sensibles a los diferentes efectos de estas sustancias; c) poder combinar racionalmente la melatonina u otros antioxidantes con pocos o ning\u00fan efecto secundario, con otros f\u00e1rmacos antitumorales ya en uso para reducir la dosis de estos \u00faltimos y, por lo tanto, sus efectos adversos; d) avanzar en el conocimiento del metabolismo tumoral y el uso de nuevos f\u00e1rmacos que act\u00faen sobre nuevas dianas terap\u00e9uticas en relaci\u00f3n con dicho metabolismo.<\/p>\n<\/div><\/li><\/ul><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>BIOGRAF\u00cdA DEL JEFE DE GRUPO<\/strong><\/p>\n<p>Carmen Rodr\u00edguez S\u00e1nchez estudi\u00f3 Medicina en la Universidad de Oviedo, licenci\u00e1ndose en 1982. Se doctor\u00f3 en 1989 en el Departamento de Morfolog\u00eda y Biolog\u00eda Celular. Realiz\u00f3 una estancia postdoctoral de 6 meses (1989) en la Universidad de Aberdeen, Escocia, Reino Unido. Luego en 1990 y 1991 realiz\u00f3 otra estancia postdoctoral de dos a\u00f1os en el Departamento de \u201cBiolog\u00eda Celular y Estructural\u201d del \u201cUniversity of Texas Health Science Center at San Antonio\u201d (UTHSCSA), San Antonio, TX, USA, en el laboratorio del Dr. Russel J. Reiter. All\u00ed comenz\u00f3 su investigaci\u00f3n sobre las acciones de la melatonina y las v\u00edas de se\u00f1alizaci\u00f3n intracelular reguladas por esta mol\u00e9cula. Es Catedr\u00e1tica de Anatom\u00eda y Embriolog\u00eda Humana en la Universidad de Oviedo. El grupo que lidera ha contribuido decisivamente desde 1995 al conocimiento de la acci\u00f3n de la melatonina, especialmente de su capacidad para regular la expresi\u00f3n g\u00e9nica (ALA-S, enzimas antioxidantes); su acci\u00f3n citoprotectora sobre c\u00e9lulas y tejidos sanos (trabajo realizado principalmente en el sistema nervioso); y su acci\u00f3n antitumoral.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>PUBLICACIONES SELECCIONADAS<\/strong><\/p>\n<ul>\n<li>Rodr\u00edguez C, Puente-Moncada N, Reiter RJ, S\u00e1nchez-S\u00e1nchez AM, Herrera F, Rodr\u00edguez-Blanco J, Duarte-Olivenza C, Turos-Cabal M, Antol\u00edn I, Mart\u00edn V. Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration. <strong><em>J Cell Physiol<\/em><\/strong> 2021, 236:27-40.<\/li>\n<li>Puente-Moncada N, Turos-Cabal M, S\u00e1nchez-S\u00e1nchez AM, Antol\u00edn I, Herrera F, Rodriguez-Blanco J, Duarte-Olivenza C, Rodriguez C, Mart\u00edn V. Role of glucose metabolism in the differential antileukemic effect of melatonin on wild\u2011type and FLT3\u2011ITD mutant cells. <strong><em>Oncol Rep<\/em><\/strong> 2020, 44:293-302.<\/li>\n<li>Puente-Moncada N, Costales P, Antol\u00edn I, Nu\u00f1ez LE, Oro P, Hermosilla M, P\u00e9rez-Escudero J, R\u00edos-Lombard\u00eda N, S\u00e1nchez-S\u00e1nchez AM, Lu\u00f1o E, Rodriguez C, Mart\u00edn V y Mor\u00eds F. The multikinase inhibitor EC70124 display potent activity in preclinical models of acute mieloid leukemia. <strong><em>Mol Cancer Ther<\/em><\/strong> 2018, 17:614-624.<\/li>\n<li>Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen D, Ayad N, Rai P, Capobianco AJ, Robbins DJ. WNT signaling drives SHH-subgroup medulloblastoma growth. <strong><em>Oncogene<\/em><\/strong> 2017, 36:6306-6314.<\/li>\n<li>Letra-Vilela R, S\u00e1nchez-S\u00e1nchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antol\u00edn I, Rodriguez C, Herrera F.\u00a0\u00a0 Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. <strong><em>Mol Cell Endocrinol<\/em><\/strong> 2016, 434:238-49.<\/li>\n<li>S\u00e1nchez-S\u00e1nchez AM, Antol\u00edn I, Puente-Moncada N, Su\u00e1rez S, G\u00f3mez-Lobo M, Rodriguez C, Mart\u00edn V. Melatonin cytotoxicity is associated to Warburg effect inhibition in Ewing\u2019s sarcoma cells. <strong><em>Plos One<\/em><\/strong>. 2015, 10:e0135420.<\/li>\n<li>Mart\u00edn V, Herrera F, Sanchez-Sanchez AM, Puente-Moncada N, Gomez-Lobo M, Antol\u00edn I, Rodriguez C. Involvement of autophagiy in melatonin-induced cytotoxicity in glioma initiating cells. <strong><em>J. Pineal Res.<\/em><\/strong> 2014, 57:308-316.<\/li>\n<li>Rodriguez C, Mart\u00edn V, Herrera F, Garc\u00eda-Santos G, Rodriguez-Blanco J, Casado-Zapico S, Sanchez-Sanchez AM, Su\u00e1rez S, Puente-Moncada N, An\u00edtua MJ and Antol\u00edn I. \u00a0Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells. <strong><em>Int. J. Mol. Sci.<\/em><\/strong> 2013, 14:6597-6613.<\/li>\n<li>Mart\u00edn V, Sanchez-Sanchez A, Herrera Garc\u00eda F, Gomez-Manzano C, Fueyo J, Alvarez Vega MA, Antol\u00edn I and Rodriguez C. Melatonin-induced methylation of the ABCG2\/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumor stem cells. <strong><em>Br. J. Cancer <\/em><\/strong>2013, 108:2005-2012.<\/li>\n<li>Garcia-Santos G; Martin V; Rodriguez-Blanco J; Herrera F; Casado-Zapico S; S\u00e1nchez-S\u00e1nchez AM, Antolin; Rodr\u00edguez C. Fas\/Fas ligand regulation mediates cell death in human Ewing\u2019s sarcoma cells treated with melatonin. <strong><em>Br J Cancer<\/em><\/strong> 2012, 106:1288-1296.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"720\" title=\"estresOxidativoTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/estresOxidativoTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/estresOxidativoTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2650\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27720%27%20viewBox%3D%270%200%20900%20720%27%3E%3Crect%20width%3D%27900%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" 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fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Miembros<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-5\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"179\"><strong>Nombre<\/strong><\/td>\n<td width=\"108\"><strong>Cargo<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Tel\u00e9fono<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Carmen Rodr\u00edguez S\u00e1nchez<\/td>\n<td width=\"108\">Catedr\u00e1tico de Universidad<\/td>\n<td width=\"252\"><a href=\"mailto:carro@uniovi.es\">carro@uniovi.es<\/a><\/td>\n<td width=\"80\">985103057<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Isaac Antol\u00edn Gonz\u00e1lez<\/td>\n<td width=\"108\">Catedr\u00e1tico de Universidad<\/td>\n<td width=\"252\"><a href=\"mailto:Iantolin@uniovi.es\">Iantolin@uniovi.es<\/a><\/td>\n<td width=\"80\">985103671<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Medina S\u00e1nchez, Mar\u00eda<\/td>\n<td width=\"108\">Catedr\u00e1tico de Escuela Universitaria<\/td>\n<td width=\"252\"><a href=\"mailto:mmedina@uniovi.es\">mmedina@uniovi.es<\/a><\/td>\n<td width=\"80\">985 10 30 78<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Marco Alvarez Vega<\/td>\n<td width=\"108\">Investigador Cl\u00ednico<\/td>\n<td width=\"252\"><a href=\"mailto:mavega@uniovi.es\">mavega@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5223<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Vanesa Mart\u00edn Fern\u00e1ndez<\/td>\n<td width=\"108\">Profesora Titular<\/td>\n<td width=\"252\"><a href=\"mailto:martinvanesa@uniovi.es\">martinvanesa@uniovi.es<\/a><\/td>\n<td width=\"80\">985103615<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Ana M\u00aa S\u00e1nchez S\u00e1nchez<\/td>\n<td width=\"108\">Profesora Ayudante Doctor<\/td>\n<td width=\"252\"><a href=\"mailto:sanchezmaria@uniovi.es\">sanchezmaria@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5223<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Noelia Puente Moncada<\/td>\n<td width=\"108\">Profesora Ayudante Doctor<\/td>\n<td width=\"252\"><a href=\"mailto:puentenoelia@uniovi.es\">puentenoelia@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5223<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Mar\u00eda Turos Cabal<\/td>\n<td width=\"108\">Investigadora Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:maria_turos27@hotmail.com\">maria_turos27@hotmail.com<\/a><\/td>\n<td width=\"80\">985103000 Ext 5223<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div 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