{"id":1119,"date":"2022-01-17T11:38:56","date_gmt":"2022-01-17T11:38:56","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1119"},"modified":"2023-06-19T11:23:36","modified_gmt":"2023-06-19T09:23:36","slug":"epigenetica-del-cancer","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/investigacion\/epigenetica-del-cancer\/","title":{"rendered":"Epigen\u00e9tica del c\u00e1ncer"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><strong>JEFE DE GRUPO<\/strong><br \/>\nMario F. Fraga<\/p>\n<p><strong>LOCALIZACI\u00d3N<\/strong><br \/>\nAvda. de la Vega, 4 \u2013 6. 33940. El Entrego, Spain<br \/>\ny Hospital Universitario Central de Asturias (HUCA)<br \/>\nFINBA, planta 0. Avda. de Roma, s\/n.<br \/>\n33011-Oviedo, Spain<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIBepigenetica\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png\" alt class=\"lazyload img-responsive wp-image-2743\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p><strong>L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/p>\n<p>La epigen\u00e9tica estudia procesos qu\u00edmicos que regulan la cromatina sin afectar a la secuencia del DNA. En los \u00faltimos a\u00f1os estos procesos han adquirido un especial protagonismo en el estudio del genoma humano. Los procesos epigen\u00e9ticos tienen un papel fundamental en la regulaci\u00f3n de la diferenciaci\u00f3n celular y sus alteraciones est\u00e1n relacionadas con numerosas patolog\u00edas como el c\u00e1ncer.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>En la actualidad nuestras l\u00edneas de trabajo se centran en el an\u00e1lisis de los procesos de metilaci\u00f3n del ADN y modificaciones postranslacionales de las histonas (a nivel \u201clocus-especifico\u201d o en el genoma completo) que puedan acontecer durante la diferenciaci\u00f3n celular y las posibles alteraciones de los mismos en el desarrollo de neoplasias y los procesos de envejecimiento.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"615\" height=\"720\" title=\"Diapositiva11\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg\" alt class=\"lazyload img-responsive wp-image-1124\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27615%27%20height%3D%27720%27%20viewBox%3D%270%200%20615%20720%27%3E%3Crect%20width%3D%27615%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-200x234.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-400x468.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-600x702.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg 615w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"570\" height=\"570\" title=\"circos-570&#215;570\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png\" alt class=\"lazyload img-responsive wp-image-1125\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27570%27%20height%3D%27570%27%20viewBox%3D%270%200%20570%20570%27%3E%3Crect%20width%3D%27570%27%20height%3D%27570%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1-200x200.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1-400x400.png 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png 570w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 570px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>Biograf\u00eda del jefe de grupo<\/strong><\/p>\n<p>Mario Fdez. Fraga es Cient\u00edfico Titular del Centro de Investigaci\u00f3n en Nanomateriales y Nanotecnolog\u00eda (CINN-CSIC). Obtuvo su Doctorado por la Universidad de Oviedo en el \u00e1rea de la epigen\u00e9tica del desarrollo, para posteriormente realizar su etapa post-doctoral en el Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO, Madrid), cuyas l\u00edneas de trabajo se centraban principalmente en el estudio de la epigen\u00e9tica de los procesos tumorales, as\u00ed como la variaci\u00f3n epigen\u00e9tica especifica existente entre individuos. En la actualidad, su principal inter\u00e9s se centra en los mecanismos epigen\u00e9ticos que participan en la diferenciaci\u00f3n celular y sus alteraciones en envejecimiento y c\u00e1ncer.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>PUBLICACIONES SELECCIONADAS<\/strong><\/p>\n<ul>\n<li>P\u00e9rez RF, Tejedor JR, Santamarina-Ojeda P, Mart\u00ednez VL, Urdinguio RG, Villama\u00f1\u00e1n L, Candiota AP, Sarr\u00f3 NMV, Barradas M, Fernandez-Marcos PJ, Serrano M, Fern\u00e1ndez AF, Fraga MF. Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse<strong>. Mol Biol Evol<\/strong>. 2021 Jul 29;38(8):3415-3435. doi: 10.1093\/molbev\/msab112. PMID: 33871658; PMCID: PMC8321527.<\/li>\n<li>Tejedor JR, Bueno C, Vinyoles M, Petazzi P, Agraz-Doblas A, Cobo I, Torres- Ruiz R, Bay\u00f3n GF, P\u00e9rez RF, L\u00f3pez-Tamargo S, Gutierrez-Ag\u00fcera F, Santamarina- Ojeda P, Ram\u00edrez-Orellana M, Bardini M, Cazzaniga G, Ballerini P, Schneider P, Stam RW, Varela I, Fraga MF, Fern\u00e1ndez AF, Men\u00e9ndez P. Integrative methylome- transcriptome analysis unravels cancer cell vulnerabilities in infant MLL- rearranged B cell acute lymphoblastic leukemia. <strong>J Clin Invest<\/strong>. 2021 Jul 1;131(13):e138833. doi: 10.1172\/JCI138833. PMID: 33983906; PMCID: PMC8245184.<\/li>\n<li>Urdinguio RG, Lopez V, Bay\u00f3n GF, Diaz de la Guardia R, Sierra MI, Garc\u00eda- Tora\u00f1o E, Perez RF, Garc\u00eda MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez- Alvarez B, L\u00f3pez-Larrea C, Bernal T, Colado E, Balb\u00edn M, Garc\u00eda-Suarez O, Chiara MD, S\u00e1enz-de-Santa-Mar\u00eda I, Rodr\u00edguez F, Pando-Sandoval A, Rodrigo L, Santos L,Salas A, Vallejo-D\u00edaz J, C Carrera A, Rico D, Hern\u00e1ndez-L\u00f3pez I, Vay\u00e1 A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Ca\u00f1al MJ, Pisano D, Gra\u00f1a- Castro O, Thomas T, Voss AK, Men\u00e9ndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF. Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment. <strong>Nucleic Acids Res<\/strong>. 2019 Jun 4;47(10):5016-5037. doi: 10.1093\/nar\/gkz195. PMID: 30923829; PMCID: PMC6547425.<\/li>\n<li>Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, \u00d6llinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, G\u00f6tzfried J, Schuck K, Hassan Z, Arbeiter A, Sch\u00f6nhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Kl\u00f6ppel G, Cadi\u00f1anos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. <strong>Nature<\/strong>. 2018 Feb 1;554(7690):62-68. doi: 10.1038\/nature25459. Epub 2018 Jan 24. PMID: 29364867; PMCID: PMC6097607.<\/li>\n<li>P\u00e9rez RF, Tejedor JR, Bay\u00f3n GF, Fern\u00e1ndez AF, Fraga MF. Distinct chromatin signatures of DNA hypomethylation in aging and cancer. <strong>Aging Cell<\/strong>. 2018 Jun;17(3):e12744. doi: 10.1111\/acel.12744. Epub 2018 Mar 5. PMID: 29504244; PMCID: PMC5946083.<\/li>\n<li>Fernandez AF, Bay\u00f3n GF, Sierra MI, Urdinguio RG, Tora\u00f1o EG, Garc\u00eda MG, Carella A, L\u00f3pez V, Santamarina P, P\u00e9rez RF, Belmonte T, Tejedor JR, Cobo I, Menendez P, Mangas C, Ferrero C, Rodrigo L, Astudillo A, Ortea I, Cueto D\u00edaz S, Rodr\u00edguez-Gonzalez P, Garc\u00eda Alonso JI, Mollejo M, Mel\u00e9ndez B, Dom\u00ednguez G, Bonilla F, Fraga MF. Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma. <strong>Hum Mol Genet<\/strong>. 2018 Sep 1;27(17):3046-3059. doi: 10.1093\/hmg\/ddy214. PMID: 29878202.<\/li>\n<li>BLUEPRINT consortium: Christoph Bock, Florian Halbritter, Francisco J Carmona, Sascha Tierling, Paul Datlinger, Yassen Assenov, Mar\u00eda Berdasco, Anke K Bergmann, Keith Booher, Florence Busato, Mihaela Campan, Christina Dahl, Christina M Dahmcke, Dinh Diep, Agust\u00edn F Fern\u00e1ndez, Clarissa Gerhauser, Andrea Haake, Katharina Heilmann, Thomas Holcomb, Dianna Hussmann, Mitsuteru Ito, Ruth Kl\u00e4ver, Martin Kreutz, Marta Kulis, Virginia Lopez, Shalima S Nair, Dirk S Paul, Nongluk Plongthongkum, Wenjia Qu, Ana C Queir\u00f3s, Frank Reinicke, Guido Sauter, Thorsten Schlomm, Aaron Statham, Clare Stirzaker, Ruslan Strogantsev, Roc\u00edo G Urdinguio, Kimberly Walter, Dieter Weichenhan, Daniel J Weisenberger, Stephan Beck, Susan J Clark, Manel Esteller, Anne C Ferguson-Smith, Mario F Fraga, Per Guldberg, Lise Lotte Hansen, Peter W Laird, Jos\u00e9 I Mart\u00edn-Subero, Anders O H Nygren, Ralf Peist, Christoph Plass, David S Shames, Reiner Siebert, Xueguang Sun, J\u00f6rg Tost, J\u00f6rn Walter, Kun Zhang. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. <strong>Nat Biotechnol<\/strong>. 2016 Jul;34(7):726-37. doi: 10.1038\/nbt.3605. Epub 2016 Jun 27. PMID: 27347756.<\/li>\n<li>Fern\u00e1ndez AF, Bay\u00f3n GF, Urdinguio RG, Tora\u00f1o EG, Garc\u00eda MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc\u00eda-Castro J, Delgado-Calle J, P\u00e9rez-Campo FM, Riancho JA, Bueno C, Men\u00e9ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic\u00f3 L, Stazi MA, Fraga MF. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. <strong>Genome Res<\/strong>. 2015 Jan;25(1):27-40. doi: 10.1101\/gr.169011.113.<\/li>\n<li>Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, Martinez-Camblor P, Obaya AJ, Bernal T, Parra-Blanco A, Rodrigo L, Santacana M, Matias-Guiu X, Soldevilla B, Dominguez G, Bonilla F, Cal S, Lopez-Otin C, Fraga MF. Immune dependent and independent anti-tumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. <strong>Cancer Res<\/strong>. 2013 Jan 1;73(1):395-405.<\/li>\n<li>Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. <strong>Nat Rev Genet.<\/strong> 2012 Jan 4;13(2):97-109.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"601\" title=\"epigenieticaTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2645\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27601%27%20viewBox%3D%270%200%20900%20601%27%3E%3Crect%20width%3D%27900%27%20height%3D%27601%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam-200x134.jpg 200w, 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class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Miembros<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-5\"><table width=\"100%\">\n<tbody>\n<tr>\n<td><strong>Nombre<\/strong><\/td>\n<td><strong>Cargo<\/strong><\/td>\n<td><strong>E-mail<\/strong><\/td>\n<td><strong>Tel\u00e9fono<\/strong><\/td>\n<\/tr>\n<tr>\n<td><b>Mario Fern\u00e1ndez Fraga<\/b><\/td>\n<td>Jefe de grupo Profesor investigaci\u00f3n CSIC<\/td>\n<td><a href=\"mailto:mffraga@cinn.es\">mffraga@cinn.es<\/a><\/td>\n<td>985733644 Ext.218<\/td>\n<\/tr>\n<tr>\n<td>Agust\u00edn Fern\u00e1ndez Fern\u00e1ndez<\/td>\n<td>Cient\u00edfico titular CSIC<\/td>\n<td><a href=\"mailto:agustin.fernandez@cinn.es\">agustin.fernandez@cinn.es<\/a><\/td>\n<td>985652411<\/td>\n<\/tr>\n<tr>\n<td>Jorge Garc\u00eda Rodr\u00edguez<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:jgrmed@hotmail.com\">jgrmed@hotmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Roc\u00edo Gonz\u00e1lez Urdinguio<\/td>\n<td>Investigadora Postdoctoral CIBER<\/td>\n<td><a href=\"mailto:rgurdinguio@gmail.com\">rgurdinguio@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Jes\u00fas M\u00aa Fern\u00e1ndez Gomez<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:jmfergomez@gmail.com\">jmfergomez@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Virginia L\u00f3pez Mart\u00ednez<\/td>\n<td>Investigadora Postdoctoral IUOPA<\/td>\n<td><a href=\"mailto:virivir@gmail.com\">virivir@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Juan Ram\u00f3n Tejedor Vaquero<\/td>\n<td>Investigador Postdoctoral Juan de la Cierva<\/td>\n<td><a href=\"mailto:juanramon.tejedor@gmail.com\">juanramon.tejedor@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Javier Fuentes Pastor<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:javifp86@gmail.com\">javifp86@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Vicente Del Amo S\u00e1nchez<\/td>\n<td>Profesor Titular UNIOVI<\/td>\n<td><a href=\"mailto:vdelamo@uniovi.es\">vdelamo@uniovi.es <\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Juan Lu\u00eds Fern\u00e1ndez Morera<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"fernandezmorera@gmail.coms\">fernandezmorera@gmail.coms<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Carmen Concell\u00f3n Fern\u00e1ndez<\/td>\n<td>Profesor Titular UNIOVI<\/td>\n<td><a href=\"mailto:ccf@uniovi.es\">ccf@uniovi.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Annalisa Roberti<\/td>\n<td>Investigadora Postdoctoral CSIC<\/td>\n<td><a href=\"mailto:robertialisa@gmail.com\">robertialisa@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Cristina Mangas Alonso<\/td>\n<td>Licenciada IUOPA<\/td>\n<td><a href=\"mailto:cristinamangas@hotmail.com\">cristinamangas@hotmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Alfonso Pe\u00f1arroya Rodr\u00edguez<\/td>\n<td>Investigador Predoctoral PFIS<\/td>\n<td><a href=\"mailto:a.penarroya@cinn.es\">a.penarroya@cinn.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Pablo Santamaria Ojeda<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:pablosoov76@gmail.com\">pablosoov76@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Juan Jos\u00e9 Alba Linares<\/td>\n<td>Investigador Predoctoral AECC<\/td>\n<td><a href=\"mailto:sirjuanjo98@gmail.com\">sirjuanjo98@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Ra\u00fal Fern\u00e1ndez P\u00e9rez<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:rauldiul@gmail.com\">rauldiul@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Javier Gancedo Verdejo<\/td>\n<td>Investigador Predoctoral FPU<\/td>\n<td><a href=\"mailto:UO258700@uniovi.es \">UO258700@uniovi.es <\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>David Bastante Rodriguez<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:d.bastante@cinn.es\">d.bastante@cinn.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1119","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1119"}],"version-history":[{"count":15,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1119\/revisions"}],"predecessor-version":[{"id":2745,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1119\/revisions\/2745"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}