{"id":1121,"date":"2022-01-17T11:39:32","date_gmt":"2022-01-17T11:39:32","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1121"},"modified":"2023-06-19T11:30:18","modified_gmt":"2023-06-19T09:30:18","slug":"genotoxicidad-y-reparacion-del-adn","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/investigacion\/genotoxicidad-y-reparacion-del-adn\/","title":{"rendered":"Genotoxicidad y reparaci\u00f3n del ADN"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>JEFE DE GRUPO<\/strong><br \/>\nLuisa Mar\u00eda Sierra Zapico<\/p>\n<p><strong>LOCALIZACI\u00d3N<\/strong><br \/>\nDpto. Biolog\u00eda Funcional. \u00c1rea de Gen\u00e9tica<br \/>\nC\/ Juli\u00e1n Claver\u00eda s\/n. 33006 Oviedo<br \/>\nEmail: <a href=\"mailto:lmsierra@uniovi.es\">lmsierra@uniovi.es<\/a><\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIBgenotoxicidad\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png\" alt class=\"lazyload img-responsive wp-image-2747\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><div style=\"text-align:center;\"><style>.fusion-button.button-1{border-radius:0 0 0 0;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-1 fusion-button-default-span \" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/emab.grupos.uniovi.es\/\"><span class=\"fusion-button-text\">P\u00e1gina web del laboratorio<\/span><\/a><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p><strong>L\u00edneas de investigaci\u00f3n<\/strong>:<\/p>\n<p>El grupo de Genotoxicidad y Reparaci\u00f3n del DNA es parte del grupo de investigaci\u00f3n de la Universidad de Oviedo \u201cEspectrometr\u00eda de Masas y An\u00e1lisis Biom\u00e9dico (EMAB)\u201d, acreditado por la ANEP, que trabaja en el desarrollo de metodolog\u00edas que permitan determinar situaciones de riesgo en la respuesta a la quimioterapia, a nivel de detecci\u00f3n y cuantificaci\u00f3n de alteraciones en la mol\u00e9cula de DNA, tanto en la secuencia como en la estructura de la cromatina, y bajo distintas condiciones celulares.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><strong>L\u00ednea 1.<\/strong> Desarrollo de un m\u00e9todo que, al menos <em>in vitro<\/em>, permite la detecci\u00f3n temprana de resistencia a quimioterapia por cisplatino, combinando la determinaci\u00f3n del f\u00e1rmaco intracelular, y el unido al DNA, con el an\u00e1lisis de la respuesta celular a la presencia del da\u00f1o en el DNA, y el de apoptosis y progresi\u00f3n del ciclo celular. La detecci\u00f3n de resistencia por este m\u00e9todo es independiente del mecanismo que la provoca.<\/p>\n<p><strong>L\u00ednea 2.<\/strong> Dise\u00f1o de metodolog\u00edas basadas en la PCR cl\u00e1sica, individual y m\u00faltiple, combinada con espectrometr\u00eda de masas, que se utiliz\u00f3 para determinar r\u00e1pida y fiablemente tanto la variaci\u00f3n del n\u00famero de copias de genes\/secuencias determinados\/as, como variaciones en la expresi\u00f3n g\u00e9nica, de varios genes simult\u00e1neamente, y tambi\u00e9n en la detecci\u00f3n y cuantificaci\u00f3n de prote\u00ednas que se utilizan como biomarcadores en procesos tumorales, cuando la PCR se combina con inmunoensayos.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>L\u00ednea 3.<\/strong> Desarrollo de metodolog\u00edas que permitan el an\u00e1lisis de la influencia de metabolitos del ciclo de Krebs, capaces de alterar tanto la metilaci\u00f3n del DNA como la estructura de la cromatina, en la modulaci\u00f3n de la respuesta a la presencia de distintos tipos de da\u00f1o en el DNA.<\/p>\n<p><strong>L\u00ednea 4.<\/strong> An\u00e1lisis de la influencia del canal i\u00f3nico de K<sup>+<\/sup> dependiente de voltaje hERG en la respuesta al da\u00f1o inducido por el agente genot\u00f3xico metil metanosulfonato, determinando que la influencia del canal, en disminuir el da\u00f1o inducido, depende de su actividad can\u00f3nica, como transportador de K<sup>+<\/sup>.<\/p>\n<p><strong>L\u00ednea 5.<\/strong> Determinaci\u00f3n de la actividad genot\u00f3xica de nanopart\u00edculas de \u00f3xido de hierro ultra-peque\u00f1as y no magn\u00e9ticas, con estructura de ferrihidrita, y recubiertas con \u00e1cidos tart\u00e1rico y ad\u00edpico, con vistas a su uso en Biomedicina.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>BIOGRAF\u00cdA DEL JEFE DE GRUPO<\/strong><\/p>\n<p>Doctora en Biolog\u00eda, por la Universidad de Oviedo, investigadora postdoctoral en el Dpt. of Radiation Genetics and Chemical Mutagenesis, de la Universidad de Leiden, Paises Bajos.<\/p>\n<p>Desde 1992, es Profesora Titular de Gen\u00e9tica en la Universidad de Oviedo. Siempre ha trabajado en el campo de la inducci\u00f3n de da\u00f1os en el ADN y en la respuesta que provocan, en t\u00e9rminos de reparaci\u00f3n e inducci\u00f3n de mutaciones. \u00daltimamente, dentro del grupo \u201cEMAB\u201d de la Universidad de Oviedo, trabaja en el desarrollo de marcadores de respuesta a quimioterapia.<\/p>\n<p>En este tiempo, ha dirigido\/codirigido Tesis Doctorales, Seminarios de Investigaci\u00f3n, etc. Es coautora de unos 50 art\u00edculos publicados en revistas internacionales de prestigio, varios cap\u00edtulos de libro, y m\u00e1s de cien comunicaciones en congresos nacionales\/internacionales, coeditora de un libro publicado por Springer Protocols, y ha participado en proyectos de investigaci\u00f3n regionales\/nacionales\/internacionales de convocatorias p\u00fablicas. Es miembro de varias sociedades cient\u00edficas y vicepresidenta de la SEMA.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><p><strong>PUBLICACIONES SELECCIONADAS<\/strong><\/p>\n<ul>\n<li>Uriol, E., M. Sierra, M.A. Comendador, J. Fra, P. Mart\u00ednez-Camplor, A.J. Lacave, L.M. Sierra (2013) Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the Comet assay as a possible predictive factor. Mutagenesis 28(1): 39-48. Doi: 10.1093\/mutage\/ges050.<\/li>\n<li>Gaiv\u00e3o, I., L.M. Sierra (2014) Drosophila Comet Assay: insights, uses and future perspectives. Frontiers in Genetics- Genomic Assay Technology. Vol. 5: 304. Doi: 10.3389\/fgene.2014.00304.<\/li>\n<li>Corte-Rodr\u00edguez, M., M. Espina, L.M. Sierra, E. Blanco, T. Ames, M. Montes-Bay\u00f3n, A. Sanz-Medel (2015). Quantitative evaluation of cellular uptake, DNA incorporation and adduct formation in cisplatin sensitive and resistant cell lines: Comparison of different Pt-containing drugs. Biochem. Pharmacol. 98 (1): 69-77. <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bcp.2015.08.112\">Doi: 10.1016\/j.bcp.2015.08.112<\/a>.<\/li>\n<li>Espina, M., Corte-Rodr\u00edguez, M., Aguado, L., Montes-Bay\u00f3n, M., Sierra, M.I., Mart\u00ednez-Camblor, P., Blanco-Gonz\u00e1lez, E., Sierra, L.M. (2017). Cisplatin resistance in cell models: evaluation of metallomic and biological predictive biomarkers to address early therapy failure. Metallomics 9:564-574. Doi: 10.1039\/c7mt00014f.<\/li>\n<li>Fern\u00e1ndez Asensio, A., T. Iglesias, A. Cotarelo, M. Espina, E. Blanco-Gonz\u00e1lez, L.M. Sierra, M. Montes-Bay\u00f3n (2018).\u00a0 Multiplex polymerase chain reaction in combination with gel electrophoresis-inductively coupled plasma mass spectrometry: A powerful tool for the determination of gene copy number variations and gene expression changes. Analytica Chimica Acta 1023: 64-73. Doi: 10.1016\/j.aca.2018.03.047.<\/li>\n<li>Fern\u00e1ndez Asensio, A., L.M. Sierra, M. Montes-Bay\u00f3n, E. Blanco-Gonz\u00e1lez (2019). Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection. Analytica Chimica Acta 1090:39-46. Doi: 10.1016\/j.aca.2019.09.047.<\/li>\n<li>Zambrano-Andazol, I., N. V\u00e1zquez, M. Chac\u00f3n, R.M. S\u00e1nchez- Avila, M. Persinal, C. Blanco, Z. Gonz\u00e1lez, R. Men\u00e9ndez, M. Sierra, A. Fern\u00e1ndez-Vega, T. S\u00e1nchez, J. Merayo-Lloves, A. Meana (2020). Reduced Graphene Oxide Membranes in Ocular Regenerative Medicine. Materials Science &amp; Engineering C-Mater Biol Appl 114: 111075. Doi: 10.1016\/J.msec.2020.111075.<\/li>\n<li>Fern\u00e1ndez-Villabrille, S., E. \u00c1lvarez-Gonz\u00e1lez, F. Barros, P. De La Pe\u00f1a, L.M. Sierra (2021). Influence of Kv11.1 (hERG1) K+ channel expression on DNA damage induced by the genotoxic agent methyl methanesulfonate. Pflu\u0308gers Archiv &#8211; Eur J Physiol 473:197\u2013217. Doi: 10.1007\/s00424-021-02517-2.<\/li>\n<li>Fern\u00e1ndez Asensio, A, E. Alvarez, A. Rodriguez, L.M. Sierra, E. Blanco-Gonz\u00e1lez (2021). Chromatographic methods coupled to mass spectrometry for the determination of oncometabolites in biological samples-A Review. Analytica Chimica Acta 1177: 338646. Doi: 10.1016\/j.aca.2021.338646.<\/li>\n<li>Fern\u00e1ndez Asensio, A., M. Corte-Rodr\u00edguez, J. Bettmer, L.M. Sierra, M. Montes-Bay\u00f3n, E. Blanco-Gonz\u00e1lez (2021). Targeting HER2 protein in individual cells using ICP-MS detection and its potential as prognostic and predictive breast cancer biomarker. Talanta 235: 122773. Doi: 10.1016\/j.talanta.2021.122773.<\/li>\n<\/ul>\n<\/div><div class=\"fusion-text fusion-text-6\"><p><strong>SEXENIOS<\/strong>: 5<\/p>\n<p><strong>\u00daLTIMO CONCEDIDO<\/strong>: 2013-2018 Concedido el 5 de junio de 2019.<\/p>\n<p><strong>Tesis dirigidas en los \u00faltimos 5 a\u00f1os<\/strong>: 2 presentadas y defendidas, una en 2017 (Premio Extraordinario de Doctorado) y otra en diciembre de 2021, y 2 m\u00e1s en realizaci\u00f3n.<\/p>\n<p><strong>PROYECTOS VIGENTES<\/strong><\/p>\n<ul>\n<li>\u201cCaracterizaci\u00f3n, seguimiento y estudio del impacto biol\u00f3gico de f\u00e1rmacos nanoestructurados y nanopart\u00edculas biogeneradas por implantes met\u00e1licos: nuevas estrategias anal\u00edticas\u201d. Financiado por Ministerio de Econom\u00eda y Competitividad. PID2019-104334RB-I00. 1\/06\/2020 a 31\/05\/2023. Investigadores Principales: Elisa Blanco Gonz\u00e1lez y Mar\u00eda Montes Bay\u00f3n.<\/li>\n<li>\u201cAyudas para Grupos de Investigaci\u00f3n de Organismos del Principado de Asturias durante el periodo 2021-2023\u201d. Financiado por Fundaci\u00f3n para la Investigacion Cientifica y Tecnica (FICYT). SV-PA-21-AYUD\/2021\/51399. PR-Proyecto Plan Regional. 01\/01\/2021 a 31\/12\/2023. Investigadora Principal: Elisa Blanco Gonz\u00e1lez.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"592\" title=\"genotoxicidadTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2660\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27592%27%20viewBox%3D%270%200%20900%20592%27%3E%3Crect%20width%3D%27900%27%20height%3D%27592%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-200x132.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-400x263.jpg 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fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) 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fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Miembros<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-7\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"250\"><strong>Nombre<\/strong><\/td>\n<td width=\"300\"><strong>Cargo<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Tel\u00e9fono<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"250\"><b>Luisa Mar\u00eda Sierra Zapico<\/b><\/td>\n<td width=\"300\">Jefe de grupo<\/td>\n<td width=\"252\"><a href=\"mailto:lmsierra@uniovi.es\">lmsierra@uniovi.es<\/a><\/td>\n<td width=\"80\">985102723<\/td>\n<\/tr>\n<tr>\n<td width=\"250\">Enol \u00c1lvarez Gonz\u00e1lez<\/td>\n<td width=\"300\">Becario Pre-Doctoral (Beca ISPA)<\/td>\n<td width=\"252\"><a href=\"mailto:UO239407@uniovi.es\">UO239407@uniovi.es<\/a><\/td>\n<td width=\"80\">985105265<\/td>\n<\/tr>\n<tr>\n<td width=\"250\">Alonso Rodr\u00edguez Pescador<\/td>\n<td width=\"300\">Estudiante de Doctorado<\/td>\n<td width=\"252\"><a href=\"mailto:UO278759@uniovi.es\">UO278759@uniovi.es<\/a><\/td>\n<td width=\"80\">985105264<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1121","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1121"}],"version-history":[{"count":19,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1121\/revisions"}],"predecessor-version":[{"id":1144,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1121\/revisions\/1144"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}