{"id":1146,"date":"2022-01-17T15:02:57","date_gmt":"2022-01-17T15:02:57","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1146"},"modified":"2024-11-07T10:59:48","modified_gmt":"2024-11-07T09:59:48","slug":"biologia-redox-y-metabolismo-en-cancer","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/investigacion\/biologia-redox-y-metabolismo-en-cancer\/","title":{"rendered":"Biolog\u00eda Redox y Metabolismo en C\u00e1ncer"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><strong>JEFE DE GRUPO<\/strong><br \/>\nRosa M. Sainz<\/p>\n<p><strong>LOCALIZACI\u00d3N<\/strong><br \/>\nLaboratorio 8.11, Dpto Morfolog\u00eda y Biolog\u00eda Celular,<br \/>\nFacultad de Medicina,<br \/>\nC\/ Juli\u00e1n Claver\u00eda, 6 33006 Oviedo<\/p>\n<p>Email: <a href=\"mailto:sainzrosa@uniovi.es\">sainzrosa@uniovi.es<\/a><br \/>\nTwitter: @bioxgroup<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p><strong>L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/p>\n<p>El principal inter\u00e9s del grupo de investigaci\u00f3n\u00a0<b>Biolog\u00eda Redox<\/b>\u00a0es el estudio del papel de las especies reactivas de ox\u00edgeno como agentes fisiol\u00f3gicos implicados en los mecanismos de se\u00f1alizaci\u00f3n celular en los procesos biol\u00f3gicos.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIB-biologia\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biologia.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biologia.png\" alt class=\"lazyload img-responsive wp-image-2777\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biologia-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biologia.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><b>1. Se\u00f1alizaci\u00f3n redox en los procesos de diferenciaci\u00f3n y muerte celular.<\/b><\/p>\n<p>Los niveles fisiol\u00f3gicos de especies reactivas de ox\u00edgeno o nitr\u00f3geno forman parte de un complejo sistema de se\u00f1alizaci\u00f3n intracelular b\u00e1sico que, a trav\u00e9s de la modificaci\u00f3n de residuos de ciste\u00edna de numerosas prote\u00ednas, forma parte de un complejo sistema de se\u00f1alizaci\u00f3n que regula la actividad entre otras de quinasas, proteasas y factores de transcripci\u00f3n, las cuales controlan los mecanismos celulares m\u00e1s b\u00e1sicos.<\/p>\n<p>Los objetivos concretos de esta l\u00ednea son:<\/p>\n<p style=\"padding-left: 40px;\">1.1 Determinar la participaci\u00f3n de prote\u00ednas implicadas en la homeostasis redox en los mecanismos de supervivencia celular<br \/>\n1.2 Evaluar los mecanismos de diferenciaci\u00f3n neuroendocrina como una estrategia de respuesta al estr\u00e9s que hace a las c\u00e9lulas tumorales resistentes a la terapia.<br \/>\n1.3 Identificar el papel del H2O2 como se\u00f1alizador celular en los mecanismos de diferenciaci\u00f3n celular de las c\u00e9lulas madre de la serie espermatog\u00e9nica y su participaci\u00f3n en los problemas asociados a la fertilidad.<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\"><p><b>2. Control redox de la progresi\u00f3n tumoral<\/b><\/p>\n<p>Las alteraciones metab\u00f3licas de las c\u00e9lulas tumorales, la infiltraci\u00f3n de los tumores por c\u00e9lulas inflamatorias o los tratamientos oncol\u00f3gicos contribuyen a elevar los niveles de estr\u00e9s oxidativo. Los efectos t\u00f3xicos del estr\u00e9s oxidativo sobre las c\u00e9lulas normales pueden ser evitados por la elevaci\u00f3n de los mecanismos de defensa antioxidante. Sin embargo, dicha elevaci\u00f3n en la c\u00e9lula tumoral favorece los mecanismos de progresi\u00f3n e invasi\u00f3n tumoral e impide la muerte celular. Para abordar esta l\u00ednea de investigaci\u00f3n, nuestros objetivos concretos son los siguientes:<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"620\" height=\"236\" title=\"Logo-Redox\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox.jpg\" alt class=\"lazyload img-responsive wp-image-1208\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27620%27%20height%3D%27236%27%20viewBox%3D%270%200%20620%20236%27%3E%3Crect%20width%3D%27620%27%20height%3D%27236%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox-200x76.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox-400x152.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox-600x228.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Logo-Redox.jpg 620w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p style=\"padding-left: 40px;\">2.1 Describir el papel de la mitocondria y prote\u00ednas antioxidantes mitocondrialesen la progresi\u00f3n tumoral.<br \/>\n2.2 Determinar el papel de la prote\u00edna TXNIP (TRX-interacting protein) como puente entre el metabolismo glucol\u00edtico y el balance redox en c\u00e1ncer.<br \/>\n2.3 Buscar nuevos biomarcadores basados en los cambios redox que ocurren en las c\u00e9lulas tumorales.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 10px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><p><b>3. Participaci\u00f3n de los osciladores redox circadianos en los procesos patol\u00f3gicos<\/b><br \/>\nSe ha definido el trabajo nocturno como un posible carcin\u00f3geno. Nuestro grupo de investigaci\u00f3n lleva m\u00e1s de 20 a\u00f1os trabajando en las propiedades biol\u00f3gicas del neuroindol pineal melatonina, que adem\u00e1s de ser mediador de los ciclos luz-oscuridad, es un potente antioxidante end\u00f3geno. Nuestros objetivos espec\u00edficos en esta l\u00ednea ser\u00e1n:<\/p>\n<p style=\"padding-left: 40px;\">3.1 Demostrar importancia de la melatonina a lo largo de la evoluci\u00f3n como modulador de los mecanismos b\u00e1sicos de supervivencia celular.<br \/>\n3.2 Investigar si existe un control redox de la maquinaria gen\u00e9tica que regula el ciclo circadiano.<br \/>\n3.3 Valorar el papel de selenoproteinas que participan en el control redox,y que sufren cambios circadianosno transcripcionales, en el c\u00e1ncer.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-flex-align-self-center\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"2560\" height=\"1266\" title=\"Imagen-pag-web-2020\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-scaled.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-scaled.jpg\" alt class=\"lazyload img-responsive wp-image-1211\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271266%27%20viewBox%3D%270%200%202560%201266%27%3E%3Crect%20width%3D%272560%27%20height%3D%271266%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-200x99.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-400x198.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-600x297.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-800x396.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-1200x593.jpg 1200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Imagen-pag-web-2020-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><p><strong>BIOGRAF\u00cdA DEL JEFE DE GRUPO<\/strong><\/p>\n<p>Rosa M. Sainz se doctor\u00f3 por la Universidad de Oviedo. Fue becaria postdoctoral del IUOPA entre los a\u00f1os 2000-2001 y despu\u00e9s recibi\u00f3 una beca del programa Fulbright-MEC para realizar una estancia postdoctoral en Health Science Center de San Antonio, (TX, USA) entre los a\u00f1os 2001-2004. En el a\u00f1o, 2005 se reincorpor\u00f3 a la Universidad de Oviedo con un contrato del Programa Ram\u00f3n y Cajal hasta el a\u00f1o 2009 y desde el a\u00f1o 2010 es Profesora Titular de Universidad del \u00c1rea de Biolog\u00eda Celular.<\/p>\n<p>Desde entonces la Dra. Sainz se ha centrado en estudiar el papel de metabolismo redox y los mecanismos de se\u00f1alizaci\u00f3n implicados en la supervivencia celular, la adquisici\u00f3n de fenotipos de resistencia y en los mecanismos de diferenciaci\u00f3n celular de c\u00e9lulas tumorales. Estas l\u00edneas investigaci\u00f3n han sido financiadas por organismos p\u00fablicos de investigaci\u00f3n tanto regionales (Plan Regional de Investigaci\u00f3n), como nacionales (FIS-ISCIII, MINECO) o internacionales (JPI ERA-HLDL).<\/p>\n<p>Es autora de m\u00e1s de 90 publicaciones en revistas cient\u00edficas con m\u00e1s de 10.000 citas acumuladas en total. Adem\u00e1s, posee un \u00edndice H=43 y ocupa una posici\u00f3n destacada entre los cient\u00edficos espa\u00f1oles en el \u00e1rea de Endocrinolog\u00eda y Metabolismo. En la actualidad es secretar\u00eda acad\u00e9mica del IUOPA y vocal de la junta directiva de la SEBC.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-7\"><p><strong>PUBLICACIONES SELECCIONADAS<\/strong><\/p>\n<ul>\n<li>Alvarez-Artime A, Cernuda-Cernuda R, Artime-Naveda F, Cepas V, Gonzalez-Menendez P, Fernandez-Vega S, Quiros-Gonzalez I, Sainz RM, Mayo JC. Melatonin-induced cytoskeleton reorganization leads to inhibition of melanoma cancer cell proliferation. International Journal of Molecular Sciences, (2020) 21 (2) IF: 4,183 Q2<\/li>\n<li>Cepas V, Collino M, Mayo JC, Sainz RM. Redox signaling and Advanced Glycation Endproducts (AGEs) in diet-related diseases. Antioxidants (2020)9(2), 142. IF: 4,520 Q1<\/li>\n<li>Bouzas-Ramos D, Cigales-Canga J, Mayo JC, Sainz RM, Ruiz-Encinar J, and Costa-Fernandez JM*. Carbon Quantum Dots codoped with nitrogen and Lanthanides for Multimodal Imaging. Advanced Functional Materials (2019), 29, 1903884. IF: 15,621, D1<\/li>\n<li>Gonzalez-Menendez P, Hevia D, Alonso-Arias R, Alvarez-Artime A, Rodriguez-Garcia A, Kinet S, Gonzalez-Pola I, Taylor N, Mayo JC, Sainz RM (2018). GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress. Redox Biology. 17, pp.112-127. IF: 7,126 D1<\/li>\n<li>Moro-Garc\u00eda MA, Mayo JC, Sainz RM, Alonso-Arias R (2018). Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes. Frontiers Immunol. 9, pp.339. IF: 6,429 Q1<\/li>\n<li>Mayo JC, Sainz RM, Gonzalez Menendez P, Cepas V, Tan DX, Reiter RJ (2017). Melatonin and sirtuins: A \u00abnot-so unexpected\u00bb relationship. Journal of Pineal Res. 62(2). IF: 11,613 D1<\/li>\n<li>Gonzalez-Menendez P, Hevia D, Mayo JC, Sainz RM. (2017). The dark side of glucose transporters in prostate cancer: are they a new feature to characterize carcinomas? International Journal of Cancer. 142-12, pp.2414-2424. IF: 7,360 Q1<\/li>\n<li>Mayo JC, Hevia, D, Quiros-Gonzalez I, Rodriguez-Garcia, A, Gonzalez-Menendez P, Cepas V, Gonzalez-Pola I, Sainz RM (2017). IGFBP3 and MAPK\/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer. Journal of Pineal Research. IF: 11,613. D1<\/li>\n<li>Hevia D, Gonzalez-Menendez P, Fernandez-Fernandez M, Cueto S, Rodriguez-Gonzalez P, Garcia-Alonso JI, Mayo JC, Sainz RM (2017). Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study. International Journal of Molecular Science. 18-8, pp.1620-1639. IF: 3,68 Q2<\/li>\n<li>Rodriguez-Garcia A, Hevia D, Gonzalez-Menendez P, Coppo L, Lu J, Holmgren A, Sainz RM(2017). Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells. Redox Biology. 12, pp.634-647. IF: 7,126 D1<\/li>\n<li>Miar A, Hevia D, Mu\u00f1oz-Cimadevilla H, Astudillo A, Velasco J, Sainz RM, Mayo JC (2015). Manganese superoxide dismutase (SOD2\/MnSOD)\/catalase and SOD2\/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon and lung cancer. Free Radical Biology &amp; Medicine. 85, pp.45- 55. IF: 5,784 Q1<\/li>\n<li>Hevia D, Gonzalez-Menendez P, Quiros-Gonzalez I, Miar A, Rodriguez-Garcia A, Tan DX, Reiter RJ, Mayo JC, Sainz RM (2015). Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer. Journal of Pineal Research. 58-2, pp.234-250. IF: 9,6 D1<\/li>\n<li>Gonzalez-Menendez P, Hevia D, Rodriguez-Garcia A, Mayo JC, Sainz RM (2014). Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells. Endocrinology. 155-9, pp.3238-3250. IF: 4,503 Q1<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><style>.fusion-imageframe.imageframe-4{ margin-bottom : 30px;}<\/style><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"599\" title=\"redoxTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2719\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27599%27%20viewBox%3D%270%200%20900%20599%27%3E%3Crect%20width%3D%27900%27%20height%3D%27599%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam-200x133.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam-400x266.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam-600x399.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam-800x532.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/redoxTeam.jpg 900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 900px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-8 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #e8e8e8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Miembros<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-8\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"179\"><strong>Nombre<\/strong><\/td>\n<td width=\"108\"><strong>Cargo<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Tel\u00e9fono<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"179\"><b>Rosa Mar\u00eda S\u00e1inz Men\u00e9ndez<\/b><\/td>\n<td width=\"108\">Jefe de grupo<\/td>\n<td width=\"252\"><a href=\"mailto:sainzrosa@uniovi.es\">sainzrosa@uniovi.es<\/a><\/td>\n<td width=\"80\">985103610<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Juan Carlos Mayo Barrallo<\/td>\n<td width=\"108\">Investigador<\/td>\n<td width=\"252\"><a href=\"mailto:mayojuan@uniovi.es\">mayojuan@uniovi.es<\/a><\/td>\n<td width=\"80\">985102730<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">David Hevia S\u00e1nchez<\/td>\n<td width=\"108\">Investigador<\/td>\n<td width=\"252\"><a href=\"mailto:heviadavid@uniovi.es\">heviadavid@uniovi.es<\/a><\/td>\n<td width=\"80\">985102730<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Isabel Quir\u00f3s Gonz\u00e1lez<\/td>\n<td width=\"108\">Investigador Posdoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:quirosisabel@uniovi.es\">quirosisabel@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5224<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Vanesa Cepas Lopez<\/td>\n<td width=\"108\">Contrato Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:cepasvanesa@uniovi.es\">cepasvanesa@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5224<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Alejandro \u00c1lvarez Artime<\/td>\n<td width=\"108\">Contrato Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:alejandroalvarezartime@gmail.com\">alejandroalvarezartime@gmail.com<\/a><\/td>\n<td width=\"80\">985103000 Ext 5224<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Alba Mor\u00e1n Alvarez<\/td>\n<td width=\"108\">Contrato Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:moranalba@uniovi.es\">moranalba@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5224<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Sergio Alc\u00f3n Rodr\u00edguez Mor\u00e1n Alvarez<\/td>\n<td width=\"108\">Estudiante de doctorado<\/td>\n<td width=\"252\"><a href=\"mailto:UO251962@uniovi.es\">UO251962@uniovi.es<\/a><\/td>\n<td width=\"80\">985103000 Ext 5224<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Bel\u00e9n Revuelta Delgado<\/td>\n<td width=\"108\">T\u00e9cnico de laboratorio<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-10{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-10 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-10{width:100% !important;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-10{width:100% !important;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-8{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1146","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1146"}],"version-history":[{"count":19,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1146\/revisions"}],"predecessor-version":[{"id":3931,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1146\/revisions\/3931"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}