{"id":1154,"date":"2022-01-17T15:04:25","date_gmt":"2022-01-17T15:04:25","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1154"},"modified":"2023-06-19T12:55:43","modified_gmt":"2023-06-19T10:55:43","slug":"biosintesis-de-moleculas-antitumorales","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/investigacion\/biosintesis-de-moleculas-antitumorales\/","title":{"rendered":"Bios\u00edntesis de mol\u00e9culas antitumorales"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>JEFES DE UNIDAD<\/strong><br \/>\nM\u00aa Carmen M\u00e9ndez Fern\u00e1ndez<br \/>\nCarlos Olano \u00c1lvarez<\/p>\n<p><strong>LOCALIZACI\u00d3N<\/strong><br \/>\nDepartamento de Biolog\u00eda Funcional.\u00a0Area de Microbiolog\u00eda.<br \/>\nFacultad de Medicina.<br \/>\nC\/ Julian Claver\u00eda s\/n<br \/>\n33006, Oviedo<\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p><strong>L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/p>\n<p>Las l\u00edneas de investigaci\u00f3n del grupo de Bios\u00edntesis de Mol\u00e9culas Antitumorales tienen como principal objetivo la generaci\u00f3n de nuevos derivados de compuestos antitumorales.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIB-biosintesis\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biosintesis.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biosintesis.png\" alt class=\"lazyload img-responsive wp-image-2783\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biosintesis-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-biosintesis.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><div style=\"text-align:center;\"><style>.fusion-button.button-1{border-radius:0 0 0 0;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-1 fusion-button-default-span \" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/biomic.grupos.uniovi.es\/inicio\"><span class=\"fusion-button-text\">P\u00e1gina web del laboratorio<\/span><\/a><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>Para ello se utilizan t\u00e9cnicas de ingenier\u00eda gen\u00e9tica aplicadas a microorganismos para el aislamiento y caracterizaci\u00f3n de los agrupamientos g\u00e9nicos implicados en la bios\u00edntesis de compuestos antitumorales y su posterior manipulaci\u00f3n. Esta manipulaci\u00f3n consiste en t\u00e9rminos generales en procesos de inactivaci\u00f3n g\u00e9nica y en la expresi\u00f3n de genes de dos o m\u00e1s rutas de bios\u00edntesis distintas en el microorganismo productor de un compuesto antitumoral. La finalidad de esta tecnolog\u00eda, denominada \u00abBios\u00edntesis Combinatoria\u00bb, es la generaci\u00f3n de nuevas mol\u00e9culas con caracter\u00edsticas estructurales diferentes a los productos naturales, gener\u00e1ndose en la mayor\u00eda de los casos mol\u00e9culas h\u00edbridas.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"448\" height=\"235\" title=\"BMA_Genome-mining-small-1\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Genome-mining-small-1.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Genome-mining-small-1.jpg\" alt class=\"lazyload img-responsive wp-image-1161\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27448%27%20height%3D%27235%27%20viewBox%3D%270%200%20448%20235%27%3E%3Crect%20width%3D%27448%27%20height%3D%27235%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Genome-mining-small-1-200x105.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Genome-mining-small-1-400x210.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Genome-mining-small-1.jpg 448w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 448px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"417\" height=\"412\" title=\"BMA_Mithraymcyin-small\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Mithraymcyin-small.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Mithraymcyin-small.jpg\" alt class=\"lazyload img-responsive wp-image-1162\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27417%27%20height%3D%27412%27%20viewBox%3D%270%200%20417%20412%27%3E%3Crect%20width%3D%27417%27%20height%3D%27412%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Mithraymcyin-small-200x198.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Mithraymcyin-small-400x395.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_Mithraymcyin-small.jpg 417w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 417px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p>En la actualidad se est\u00e1 trabajando tambi\u00e9n en la identificaci\u00f3n y aislamiento de nuevos antitumorales producidos por actinomicetos aislados a partir de hormigas cortadoras de hojas, procedentes de Per\u00fa. En esta l\u00ednea se est\u00e1n secuenciando genomas de estos actinomicetos para la activaci\u00f3n, mediante manipulaci\u00f3n gen\u00e9tica, de agrupamientos g\u00e9nicos que por sus caracter\u00edsticas estructurales puedan determinar la producci\u00f3n de nuevas mol\u00e9culas antitumorales silenciadas en las condiciones est\u00e1ndar de crecimiento bacteriano utilizadas en el laboratorio.<\/p>\n<\/div><div class=\"fusion-text fusion-text-4\"><p>Por otro lado, son objeto tambi\u00e9n de estudio las rutas metab\u00f3licas y los sistemas de regulaci\u00f3n implicados en la bios\u00edntesis de estos compuestos, con el fin de mejorar la producci\u00f3n de los compuestos antitumorales generados.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 10px;margin-top : 0px;padding-right : 30px;padding-bottom : 10px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><p><strong>L\u00edneas de investiaci\u00f3n: <\/strong><\/p>\n<p>\u2022 Caracterizaci\u00f3n de rutas de bios\u00edntesis de compuestos antitumorales.<br \/>\n\u2022 Generaci\u00f3n de nuevos antitumorales mediante bios\u00edntesis combinatoria.<br \/>\n\u2022 Mejora de la producci\u00f3n de compuestos antitumorales.<br \/>\n\u2022 Ingenier\u00eda metab\u00f3lica de rutas de bios\u00edntesis.<br \/>\n\u2022 Aplicaci\u00f3n de la miner\u00eda gen\u00f3mica para activar rutas de bios\u00edntesis \u00absilenciosas\u00bb e identificar nuevos compuestos antitumorales.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-flex-align-self-center\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"448\" height=\"336\" title=\"OLYMPUS DIGITAL CAMERA\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_l1-1.jpg-1.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_l1-1.jpg-1.jpg\" alt class=\"lazyload img-responsive wp-image-1165\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27448%27%20height%3D%27336%27%20viewBox%3D%270%200%20448%20336%27%3E%3Crect%20width%3D%27448%27%20height%3D%27336%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_l1-1.jpg-1-200x150.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_l1-1.jpg-1-400x300.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/BMA_l1-1.jpg-1.jpg 448w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 448px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><p><strong>BIOGRAF\u00cdA DE LOS JEFES DE GRUPO<\/strong><\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;border-width: 0 2px 0 0;border-color:#76b5ae;border-style:solid;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-7\"><p><b>Carmen M\u00e9ndez<\/b>\u00a0se doctor\u00f3 en la Universidad de Oviedo (Espa\u00f1a) en 1984 realizando su Tesis Doctoral sobre la caracterizaci\u00f3n del proceso de diferenciaci\u00f3n de colonias de Streptomyces antibioticus. En 1988, despu\u00e9s de realizar una estancia posdoctoral en el laboratorio de Keith Chater (Norwich, UK), se reincorpor\u00f3 a la Universidad de Oviedo como profesora titular del \u00c1rea de Microbiolog\u00eda. Posteriormente, en 2011 obtuvo una C\u00e1tedra de Microbiolog\u00eda en la Universidad de Oviedo. Sus intereses cient\u00edficos se centran en la clonaci\u00f3n y caracterizaci\u00f3n de rutas de bios\u00edntesis de compuestos antibi\u00f3ticos y antitumorales producidos por actinomicetos, la generaci\u00f3n de nuevos compuestos con actividad antibi\u00f3tica o antitumoral mediante Bios\u00edntesis Combinatoria, y la activaci\u00f3n de rustas de bios\u00edntesis silenciosas en actinomicetos.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-8\"><p><strong>Carlos Olano<\/strong> es licenciado en Ciencias Biol\u00f3gicas (1991) y Doctor en Biolog\u00eda (1995) por la Universidad de Oviedo. Tras una estancia postdoctoral (1997-2000) en la School of Pharmacy de la Universidad de Wisconsin-Madison (Estados unidos), se reincorpora a la Universidad de Oviedo con un contrato de investigador en el Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA). Posteriormente, tras obtener una plaza de Profesor Ayudante Doctor en la Universidad de Oviedo, obtiene en 2021 una plaza de Profesor Titular de Microbiolog\u00eda en la misma universidad. Forma parte, desde su inicio, del grupo de investigaci\u00f3n \u201cBios\u00edntesis de compuestos bioactivos por microorganismos (BIOMIC)\u201d de la Universidad de Oviedo. Sus objetivos cient\u00edficos a medio-largo plazo se centran en: identificar nuevas rutas de metabolitos secundarios, producidos por actinomicetos, mediante miner\u00eda gen\u00f3mica; identificar nuevos compuestos bioactivos producidos por actinomicetos; el aislamiento y caracterizaci\u00f3n nuevas rutas de bios\u00edntesis de compuestos bioactivos; la aplicaci\u00f3n de bios\u00edntesis combinatoria para generar nuevos derivados; y en la utilizaci\u00f3n de estrategias de ingenier\u00eda gen\u00e9tica para activar agrupaciones de bios\u00edntesis cr\u00edpticas\/silenciosas identificadas por miner\u00eda gen\u00f3mica en los genomas de actinomicetos.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-10{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-10 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;border-width: 2px 0 0 0;border-color:#76b5ae;border-style:solid;padding: 30px 0px 0px 0px;\"><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-11{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-11 > .fusion-column-wrapper {padding-top : 30px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-12 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-9\"><p><strong>PUBLICACIONES SELECCIONADAS<\/strong><\/p>\n<ul>\n<li>Prado-Alonso L, P\u00e9rez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Mart\u00edn J, Reyes F, M\u00e9ndez C, Salas JA, Olano C. (2022).\u00a0 Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by\u00a0<em>Streptomyces<\/em>\u00a0sp. Strain CS147. Appl Environ Microbiol. 88(1): e0183921.<\/li>\n<li>Ceniceros A, Cuervo L, M\u00e9ndez C, Salas JA, Olano C, Malmierca MG. (2021).\u00a0 A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a\u00a0<em>Streptomyces<\/em>\u00a0Strain Collection Isolated from Leaf-Cutting Ants. Microorganisms. 9(11): 2225.<\/li>\n<li>Botas A, Eitel M, Schwarz PN, Buchmann A, Costales P, N\u00fa\u00f1ez LE, Cort\u00e9s J, Mor\u00eds F, Krawiec M, Wola\u0144ski M, Gust B, Rodriguez M, Fischer WN, Jandeleit B, Zakrzewska-Czerwi\u0144ska J, Wohlleben W, Stegmann E, Koch P, M\u00e9ndez C, Gross H. (2021). Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardin\u2005A. Angew Chem Int Ed Engl. 60(24): 13536-13541.<\/li>\n<li>Malmierca MG, P\u00e9rez-Victoria I, Mart\u00edn J, Reyes F, M\u00e9ndez C, Salas JA, Olano C. (2020). New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway. Applied and Environmental Microbiology 86(3):e02453-19.<\/li>\n<\/ul>\n<ul>\n<li>Becerril A, Perez-Victoria I, Ye S, Brana AF, Martin J, Reyes F, Salas JA, Mendez C. (2020). Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family. ACS Chemical Biology 15 (6): 1541-1553.<\/li>\n<li>Zabala D, Song LJ, Dashti Y, Challis GL, Salas JA, Mendez C. (2020). Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin. Microbial Cell Factories 19(1). 111.<\/li>\n<li>Becerril A, \u00c1lvarez S, Bra\u00f1a AF, Rico S, D\u00edaz M, Santamar\u00eda RI, Salas JA, M\u00e9ndez C. (2018). Uncovering production of specialized metabolites by <em>Streptomyces argillaceus<\/em>: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches. PLoS One. 24;13(5):e0198145.<\/li>\n<li>Ye S, Bra\u00f1a AF, Gonz\u00e1lez-Sab\u00edn J, Moris JF, Olano C, Salas JA, M\u00e9ndez C. (2018). New insights into the biosynthesis pathway of polyketide alkaloid argimycins P in <em>Streptomyces argillaceus<\/em>. Frontiers in Microbiology 9:252.<\/li>\n<li>Malmierca MG, P\u00e9rez-Victoria I, Mart\u00edn J, Reyes F, M\u00e9ndez C, Olano C, Salas JA. (2018). Cooperative involvement of glycosyltransferases in the transfer of aminosugars in the biosynthesis of the macrolactam sipanmycin by <em>Streptomyces<\/em> sp. CS149. Applied and Environmental Microbiology 84 (18) e01462-18.<\/li>\n<\/ul>\n<ul>\n<li>N\u00fa\u00f1ez LE, Nybo SE, Gonz\u00e1lez-Sab\u00edn J, P\u00e9rez M, Men\u00e9ndez N, Bra\u00f1a AF, Shaaban KA, He M, Mor\u00eds F, Salas JA, Rohr J, M\u00e9ndez C. (2012). A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis. J Med Chem. 55(12):5813-25.<\/li>\n<\/ul>\n<\/div><div ><span class=\" fusion-imageframe imageframe-none imageframe-5 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"596\" title=\"biosintesisTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2666\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27596%27%20viewBox%3D%270%200%20900%20596%27%3E%3Crect%20width%3D%27900%27%20height%3D%27596%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam-200x132.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam-400x265.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam-600x397.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam-800x530.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/biosintesisTeam.jpg 900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 900px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-12{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-12 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-13 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-13{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-13 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-13{width:100% !important;}.fusion-builder-column-13 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-13{width:100% !important;}.fusion-builder-column-13 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-8 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #e8e8e8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-14 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Miembros<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-14{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-14 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-14{width:100% !important;}.fusion-builder-column-14 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-14{width:100% !important;}.fusion-builder-column-14 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-15 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-10\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"179\"><strong>Nombre<\/strong><\/td>\n<td width=\"108\"><strong>Cargo<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Tel\u00e9fono<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"179\"><b>Carmen M\u00e9ndez Fern\u00e1ndez<\/b><\/td>\n<td width=\"108\">Jefe de grupo<\/td>\n<td width=\"252\"><a href=\"mailto:cmendezf@uniovi.es\">cmendezf@uniovi.es<\/a><\/td>\n<td width=\"80\">985 103 558<\/td>\n<\/tr>\n<tr>\n<td width=\"179\"><b>Carlos Olano \u00c1lvarez<\/b><\/td>\n<td width=\"108\">Jefe de grupo<\/td>\n<td width=\"252\"><a href=\"mailto:olanocarlos@uniovi.es\">olanocarlos@uniovi.es<\/a><\/td>\n<td width=\"80\">985 105 288<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Gloria Blanco Blanco<\/td>\n<td width=\"108\">Investigador<\/td>\n<td width=\"252\"><a href=\"mailto:gbb@uniovi.es\">gbb@uniovi.es<\/a><\/td>\n<td width=\"80\">985 103 205<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">M\u00f3nica G\u00f3mez Malmierca<\/td>\n<td width=\"108\">Investigador Postdoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:gomezmonica@uniovi.es\">gomezmonica@uniovi.es<\/a><\/td>\n<td width=\"80\">985 105 288<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Lorena Cuervo del Pozo<\/td>\n<td width=\"108\"><\/td>\n<td width=\"252\"><a href=\"mailto:cuervolorena@uniovi.es\">cuervolorena@uniovi.es<\/a><\/td>\n<td width=\"80\">985 105 288<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Miriam Rodr\u00edguez Garc\u00eda<\/td>\n<td width=\"108\">Investigador Postdoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:miroga03@hotmail.com\">miroga03@hotmail.com<\/a><\/td>\n<td width=\"80\">985 105 287<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Laura Prado Alonso<\/td>\n<td width=\"108\">Investigador Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:laura-prado@outlook.com\">laura-prado@outlook.com<\/a><\/td>\n<td width=\"80\">985 105 288<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Coral Garc\u00eda Guti\u00e9rrez<\/td>\n<td width=\"108\">Investigador Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:coral93@hotmail.es\">coral93@hotmail.es<\/a><\/td>\n<td width=\"80\">985 105 287<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Mar\u00eda Soledad Gonz\u00e1lez Moreno<\/td>\n<td width=\"108\">Investigador Predoctoral<\/td>\n<td width=\"252\"><a href=\"mailto:msol95gm@gmail.com\">msol95gm@gmail.com<\/a><\/td>\n<td width=\"80\">985 105 287<\/td>\n<\/tr>\n<tr>\n<td width=\"179\">Leire Pe\u00f1a Noval<\/td>\n<td width=\"108\">T\u00e9cnico de laboratorio<\/td>\n<td width=\"252\"><a href=\"mailto:penaleire@uniovi.es\">penaleire@uniovi.es<\/a><\/td>\n<td width=\"80\">985 105 287<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-15{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-15 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-15{width:100% !important;order : 0;}.fusion-builder-column-15 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-15{width:100% !important;order : 0;}.fusion-builder-column-15 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-16 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-16{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-16 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-16{width:100% !important;order : 0;}.fusion-builder-column-16 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-16{width:100% !important;order : 0;}.fusion-builder-column-16 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-8{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 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