{"id":1507,"date":"2022-01-31T11:36:01","date_gmt":"2022-01-31T11:36:01","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1507"},"modified":"2023-06-19T11:24:02","modified_gmt":"2023-06-19T09:24:02","slug":"cancer-epigenetics","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/en\/research\/cancer-epigenetics\/","title":{"rendered":"Cancer Epigenetics"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>UNIT HEAD<\/strong><br \/>\nMario F. Fraga<\/p>\n<p><strong>LOCATION<\/strong><br \/>\nAvda. de la Vega, 4 \u2013 6. 33940. El Entrego, Spain<br \/>\ny Hospital Universitario Central de Asturias (HUCA)<br \/>\nFINBA, planta 0. Avda. de Roma, s\/n.<br \/>\n33011-Oviedo, Spain<\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIBepigenetica\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png\" alt class=\"lazyload img-responsive wp-image-2743\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBepigenetica.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p><strong>RESEARCH LINES<\/strong><\/p>\n<p>Epigenetics has become a fundamental discipline in the study of genome biology. Cell growth and differentiation is largely regulated by epigenetic processes. The alteration of these epigenetic mechanisms is associated with numerous pathologies, notably cancer.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>Currently, our research focuses on the study of locus-specific and genome-wide epigenetic mechanisms such as DNA methylation and histone post-translational modifications during cell differentiation, and their alterations in cancer and aging.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"615\" height=\"720\" title=\"Diapositiva11\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg\" alt class=\"lazyload img-responsive wp-image-1124\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27615%27%20height%3D%27720%27%20viewBox%3D%270%200%20615%20720%27%3E%3Crect%20width%3D%27615%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-200x234.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-400x468.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11-600x702.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Diapositiva11.jpg 615w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"570\" height=\"570\" title=\"circos-570&#215;570\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png\" alt class=\"lazyload img-responsive wp-image-1125\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27570%27%20height%3D%27570%27%20viewBox%3D%270%200%20570%20570%27%3E%3Crect%20width%3D%27570%27%20height%3D%27570%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1-200x200.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1-400x400.png 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/circos-570x570-1.png 570w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 570px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>GROUP HEAD BIOGRAPHY<\/strong><\/p>\n<p>Mario F. Fraga is a Tenured Scientist at the Nanomaterials and Nanotechnology Center (CINN-CSIC). He received his Ph.D. in developmental epigenetics from the University of Oviedo, and was a \u201cRamon y Cajal\u201d postdoctoral fellow in the Spanish National Cancer Research Centre (CNIO), where his research was focused on cancer epigenetics and the study of inter-individual epigenetic variation. The research interests of his team are in epigenetic processes involved in cell differentiation and their alterations in cancer and aging.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>SELECTED PUBLICATIONS<\/strong><\/p>\n<ul>\n<li>P\u00e9rez RF, Tejedor JR, Santamarina-Ojeda P, Mart\u00ednez VL, Urdinguio RG, Villama\u00f1\u00e1n L, Candiota AP, Sarr\u00f3 NMV, Barradas M, Fernandez-Marcos PJ, Serrano M, Fern\u00e1ndez AF, Fraga MF. Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse<strong>. Mol Biol Evol<\/strong>. 2021 Jul 29;38(8):3415-3435. doi: 10.1093\/molbev\/msab112. PMID: 33871658; PMCID: PMC8321527.<\/li>\n<li>Tejedor JR, Bueno C, Vinyoles M, Petazzi P, Agraz-Doblas A, Cobo I, Torres- Ruiz R, Bay\u00f3n GF, P\u00e9rez RF, L\u00f3pez-Tamargo S, Gutierrez-Ag\u00fcera F, Santamarina- Ojeda P, Ram\u00edrez-Orellana M, Bardini M, Cazzaniga G, Ballerini P, Schneider P, Stam RW, Varela I, Fraga MF, Fern\u00e1ndez AF, Men\u00e9ndez P. Integrative methylome- transcriptome analysis unravels cancer cell vulnerabilities in infant MLL- rearranged B cell acute lymphoblastic leukemia. <strong>J Clin Invest<\/strong>. 2021 Jul 1;131(13):e138833. doi: 10.1172\/JCI138833. PMID: 33983906; PMCID: PMC8245184.<\/li>\n<li>Urdinguio RG, Lopez V, Bay\u00f3n GF, Diaz de la Guardia R, Sierra MI, Garc\u00eda- Tora\u00f1o E, Perez RF, Garc\u00eda MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez- Alvarez B, L\u00f3pez-Larrea C, Bernal T, Colado E, Balb\u00edn M, Garc\u00eda-Suarez O, Chiara MD, S\u00e1enz-de-Santa-Mar\u00eda I, Rodr\u00edguez F, Pando-Sandoval A, Rodrigo L, Santos L,Salas A, Vallejo-D\u00edaz J, C Carrera A, Rico D, Hern\u00e1ndez-L\u00f3pez I, Vay\u00e1 A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Ca\u00f1al MJ, Pisano D, Gra\u00f1a- Castro O, Thomas T, Voss AK, Men\u00e9ndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF. Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment. <strong>Nucleic Acids Res<\/strong>. 2019 Jun 4;47(10):5016-5037. doi: 10.1093\/nar\/gkz195. PMID: 30923829; PMCID: PMC6547425.<\/li>\n<li>Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, \u00d6llinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, G\u00f6tzfried J, Schuck K, Hassan Z, Arbeiter A, Sch\u00f6nhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Kl\u00f6ppel G, Cadi\u00f1anos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. <strong>Nature<\/strong>. 2018 Feb 1;554(7690):62-68. doi: 10.1038\/nature25459. Epub 2018 Jan 24. PMID: 29364867; PMCID: PMC6097607.<\/li>\n<li>P\u00e9rez RF, Tejedor JR, Bay\u00f3n GF, Fern\u00e1ndez AF, Fraga MF. Distinct chromatin signatures of DNA hypomethylation in aging and cancer. <strong>Aging Cell<\/strong>. 2018 Jun;17(3):e12744. doi: 10.1111\/acel.12744. Epub 2018 Mar 5. PMID: 29504244; PMCID: PMC5946083.<\/li>\n<li>Fernandez AF, Bay\u00f3n GF, Sierra MI, Urdinguio RG, Tora\u00f1o EG, Garc\u00eda MG, Carella A, L\u00f3pez V, Santamarina P, P\u00e9rez RF, Belmonte T, Tejedor JR, Cobo I, Menendez P, Mangas C, Ferrero C, Rodrigo L, Astudillo A, Ortea I, Cueto D\u00edaz S, Rodr\u00edguez-Gonzalez P, Garc\u00eda Alonso JI, Mollejo M, Mel\u00e9ndez B, Dom\u00ednguez G, Bonilla F, Fraga MF. Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma. <strong>Hum Mol Genet<\/strong>. 2018 Sep 1;27(17):3046-3059. doi: 10.1093\/hmg\/ddy214. PMID: 29878202.<\/li>\n<li>BLUEPRINT consortium: Christoph Bock, Florian Halbritter, Francisco J Carmona, Sascha Tierling, Paul Datlinger, Yassen Assenov, Mar\u00eda Berdasco, Anke K Bergmann, Keith Booher, Florence Busato, Mihaela Campan, Christina Dahl, Christina M Dahmcke, Dinh Diep, Agust\u00edn F Fern\u00e1ndez, Clarissa Gerhauser, Andrea Haake, Katharina Heilmann, Thomas Holcomb, Dianna Hussmann, Mitsuteru Ito, Ruth Kl\u00e4ver, Martin Kreutz, Marta Kulis, Virginia Lopez, Shalima S Nair, Dirk S Paul, Nongluk Plongthongkum, Wenjia Qu, Ana C Queir\u00f3s, Frank Reinicke, Guido Sauter, Thorsten Schlomm, Aaron Statham, Clare Stirzaker, Ruslan Strogantsev, Roc\u00edo G Urdinguio, Kimberly Walter, Dieter Weichenhan, Daniel J Weisenberger, Stephan Beck, Susan J Clark, Manel Esteller, Anne C Ferguson-Smith, Mario F Fraga, Per Guldberg, Lise Lotte Hansen, Peter W Laird, Jos\u00e9 I Mart\u00edn-Subero, Anders O H Nygren, Ralf Peist, Christoph Plass, David S Shames, Reiner Siebert, Xueguang Sun, J\u00f6rg Tost, J\u00f6rn Walter, Kun Zhang. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. <strong>Nat Biotechnol<\/strong>. 2016 Jul;34(7):726-37. doi: 10.1038\/nbt.3605. Epub 2016 Jun 27. PMID: 27347756.<\/li>\n<li>Fern\u00e1ndez AF, Bay\u00f3n GF, Urdinguio RG, Tora\u00f1o EG, Garc\u00eda MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc\u00eda-Castro J, Delgado-Calle J, P\u00e9rez-Campo FM, Riancho JA, Bueno C, Men\u00e9ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic\u00f3 L, Stazi MA, Fraga MF. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. <strong>Genome Res<\/strong>. 2015 Jan;25(1):27-40. doi: 10.1101\/gr.169011.113.<\/li>\n<li>Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, Martinez-Camblor P, Obaya AJ, Bernal T, Parra-Blanco A, Rodrigo L, Santacana M, Matias-Guiu X, Soldevilla B, Dominguez G, Bonilla F, Cal S, Lopez-Otin C, Fraga MF. Immune dependent and independent anti-tumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. <strong>Cancer Res<\/strong>. 2013 Jan 1;73(1):395-405.<\/li>\n<li>Feil R, Fraga MF. Epigenetics and the environment: emerging patterns and implications. <strong>Nat Rev Genet.<\/strong> 2012 Jan 4;13(2):97-109.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"601\" title=\"epigenieticaTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2645\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27601%27%20viewBox%3D%270%200%20900%20601%27%3E%3Crect%20width%3D%27900%27%20height%3D%27601%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam-200x134.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam-400x267.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam-600x401.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam-800x534.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/epigenieticaTeam.jpg 900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 900px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" 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1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #e8e8e8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Personnel<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-5\"><table width=\"100%\">\n<tbody>\n<tr>\n<td><strong>Name<\/strong><\/td>\n<td><strong>Position<\/strong><\/td>\n<td><strong>E-mail<\/strong><\/td>\n<td><strong>Phone<\/strong><\/td>\n<\/tr>\n<tr>\n<td><b>Mario Fern\u00e1ndez Fraga<\/b><\/td>\n<td>Jefe de grupo Profesor investigaci\u00f3n CSIC<\/td>\n<td><a href=\"mailto:mffraga@cinn.es\">mffraga@cinn.es<\/a><\/td>\n<td>985733644 Ext.218<\/td>\n<\/tr>\n<tr>\n<td>Agust\u00edn Fern\u00e1ndez Fern\u00e1ndez<\/td>\n<td>Cient\u00edfico titular CSIC<\/td>\n<td><a href=\"mailto:agustin.fernandez@cinn.es\">agustin.fernandez@cinn.es<\/a><\/td>\n<td>985652411<\/td>\n<\/tr>\n<tr>\n<td>Jorge Garc\u00eda Rodr\u00edguez<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:jgrmed@hotmail.com\">jgrmed@hotmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Roc\u00edo Gonz\u00e1lez Urdinguio<\/td>\n<td>Investigadora Postdoctoral CIBER<\/td>\n<td><a href=\"mailto:rgurdinguio@gmail.com\">rgurdinguio@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Jes\u00fas M\u00aa Fern\u00e1ndez Gomez<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:jmfergomez@gmail.com\">jmfergomez@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Virginia L\u00f3pez Mart\u00ednez<\/td>\n<td>Investigadora Postdoctoral IUOPA<\/td>\n<td><a href=\"mailto:virivir@gmail.com\">virivir@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Juan Ram\u00f3n Tejedor Vaquero<\/td>\n<td>Investigador Postdoctoral Juan de la Cierva<\/td>\n<td><a href=\"mailto:juanramon.tejedor@gmail.com\">juanramon.tejedor@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Javier Fuentes Pastor<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"mailto:javifp86@gmail.com\">javifp86@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Vicente Del Amo S\u00e1nchez<\/td>\n<td>Profesor Titular UNIOVI<\/td>\n<td><a href=\"mailto:vdelamo@uniovi.es\">vdelamo@uniovi.es <\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Juan Lu\u00eds Fern\u00e1ndez Morera<\/td>\n<td>Facultativo especialista<\/td>\n<td><a href=\"fernandezmorera@gmail.coms\">fernandezmorera@gmail.coms<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Carmen Concell\u00f3n Fern\u00e1ndez<\/td>\n<td>Profesor Titular UNIOVI<\/td>\n<td><a href=\"mailto:ccf@uniovi.es\">ccf@uniovi.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Annalisa Roberti<\/td>\n<td>Investigadora Postdoctoral CSIC<\/td>\n<td><a href=\"mailto:robertialisa@gmail.com\">robertialisa@gmail.com<\/a><\/td>\n<td>985652412<\/td>\n<\/tr>\n<tr>\n<td>Cristina Mangas Alonso<\/td>\n<td>Licenciada IUOPA<\/td>\n<td><a href=\"mailto:cristinamangas@hotmail.com\">cristinamangas@hotmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Alfonso Pe\u00f1arroya Rodr\u00edguez<\/td>\n<td>Investigador Predoctoral PFIS<\/td>\n<td><a href=\"mailto:a.penarroya@cinn.es\">a.penarroya@cinn.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Pablo Santamaria Ojeda<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:pablosoov76@gmail.com\">pablosoov76@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Juan Jos\u00e9 Alba Linares<\/td>\n<td>Investigador Predoctoral AECC<\/td>\n<td><a href=\"mailto:sirjuanjo98@gmail.com\">sirjuanjo98@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Ra\u00fal Fern\u00e1ndez P\u00e9rez<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:rauldiul@gmail.com\">rauldiul@gmail.com<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>Javier Gancedo Verdejo<\/td>\n<td>Investigador Predoctoral FPU<\/td>\n<td><a href=\"mailto:UO258700@uniovi.es \">UO258700@uniovi.es <\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<tr>\n<td>David Bastante Rodriguez<\/td>\n<td>Investigador Predoctoral Severo Ochoa<\/td>\n<td><a href=\"mailto:d.bastante@cinn.es\">d.bastante@cinn.es<\/a><\/td>\n<td>985101768<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1492,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1507"}],"version-history":[{"count":7,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1507\/revisions"}],"predecessor-version":[{"id":2746,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1507\/revisions\/2746"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1492"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}