{"id":1509,"date":"2022-01-31T11:40:41","date_gmt":"2022-01-31T11:40:41","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1509"},"modified":"2023-06-19T11:30:59","modified_gmt":"2023-06-19T09:30:59","slug":"genotoxicity-and-dna-repair","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/en\/research\/genotoxicity-and-dna-repair\/","title":{"rendered":"Genotoxicity and DNA repair"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>UNIT HEAD<\/strong><br \/>\nLuisa Mar\u00eda Sierra Zapico<\/p>\n<p><strong>LOCATION<\/strong><br \/>\nDpto. Biolog\u00eda Funcional. \u00c1rea de Gen\u00e9tica<br \/>\nC\/ Juli\u00e1n Claver\u00eda s\/n. 33006 Oviedo<br \/>\nEmail: <a href=\"mailto:lmsierra@uniovi.es\">lmsierra@uniovi.es<\/a><\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"400\" height=\"320\" title=\"PIBgenotoxicidad\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png\" alt class=\"lazyload img-responsive wp-image-2747\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27320%27%20viewBox%3D%270%200%20400%20320%27%3E%3Crect%20width%3D%27400%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad-200x160.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIBgenotoxicidad.png 400w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><div style=\"text-align:center;\"><style>.fusion-button.button-1{border-radius:0 0 0 0;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-1 fusion-button-default-span \" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/emab.grupos.uniovi.es\/\"><span class=\"fusion-button-text\">Lab web page<\/span><\/a><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p><b>RESEARCH LINES<\/b><\/p>\n<p>This group of Genotoxicity and DNA Repair is part of the research group from the University of Oviedo \u201cMass spectrometry and biomedical analysis, (EMAB)\u201d, accredited by ANEP, that works developing methodologies to allow the determination of risk situations in chemotherapy response, detecting and quantifying alterations at the DNA sequence and at the chromatin structure, in different cellular conditions.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><strong>Research line 1.<\/strong> Development of a method that, at least <em>in vitro<\/em>, allows the early detection of cisplatin resistance, combining the determination of intracellular and DNA adducted drug with a DNA damage response analysis, and with the determination of apoptosis and cell cycle progression. This resistance detection is independent of the inductor mechanism.<\/p>\n<p><strong>Research line 2.<\/strong> Design of methodologies based on classic single and multiplex PCR combined with mass spectrometry, without DNA fragment size limitation, that might be used to study, in a fast and reliable way, both variations in gene\/sequence copy numbers and in gene expression, of several genes simultaneously, as well as detecting and quantifying proteins used as biomarkers in tumour processes, when the PCR is combined with immunoassays.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>Research line 3.<\/strong> Development of methodologies to check the possible influence of Krebs\u2019s cycle metabolites, that alter DNA methylation and chromatin structure, as modulators of DNA damage responses, against different types of DNA damage.<\/p>\n<p><strong>Research line 4.<\/strong> Analysis of the influence of the hERG voltage-dependent K<sup>+<\/sup> channel on the DNA damage response induced by the genotoxic chemical methyl methanesulfonate, determining that the channel influence, decreasing the induced DNA damage, depends on its canonical activity as K<sup>+<\/sup> carrier.<\/p>\n<p><strong>Research line 5.<\/strong> Determination of the genotoxic activity of iron nanoparticles, ultra-small and non-magnetic, with ferrihydrite structure and coated by adipic and tartaric acids, just to check their possible use in Biomedicine.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>GROUP HEAD BIOGRAPHY<\/strong><\/p>\n<p>Doctor in Biology (Ph.D.) by the University of Oviedo, was postdoctoral fellow at the Radiation Genetics and Chemical Mutagenesis Department, from the Leiden University in The Netherlands.<\/p>\n<p>From 1992, she has a permanent position as Associate Professor of Genetics, at the University of Oviedo. She has always worked studying induction of DNA damage and their response, in terms of DNA repair and mutation induction. Lately, within the \u201cMass spectrometry and Biomedical Analysis\u201d group from the University of Oviedo, she works developing possible markers of chemotherapy response.<\/p>\n<p>In this time, she has been supervisor of Ph.D. Thesis, Research Seminars, etc. She has participated in research projects, regional\/national\/international from public calls. She is co-author of around 50 papers on international prestigious journals, several book chapters, more than hundred communications to national\/international conferences, as well as co-editor of a book published by Springer Protocols. She is member of several scientific societies and Vice-president of SEMA.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><p><strong>SELECTED PUBLICATIONS<\/strong><\/p>\n<ul>\n<li>Uriol, E., M. Sierra, M.A. Comendador, J. Fra, P. Mart\u00ednez-Camplor, A.J. Lacave, L.M. Sierra (2013) Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the Comet assay as a possible predictive factor. Mutagenesis 28(1): 39-48. Doi: 10.1093\/mutage\/ges050.<\/li>\n<li>Gaiv\u00e3o, I., L.M. Sierra (2014) Drosophila Comet Assay: insights, uses and future perspectives. Frontiers in Genetics- Genomic Assay Technology. Vol. 5: 304. Doi: 10.3389\/fgene.2014.00304.<\/li>\n<li>Corte-Rodr\u00edguez, M., M. Espina, L.M. Sierra, E. Blanco, T. Ames, M. Montes-Bay\u00f3n, A. Sanz-Medel (2015). Quantitative evaluation of cellular uptake, DNA incorporation and adduct formation in cisplatin sensitive and resistant cell lines: Comparison of different Pt-containing drugs. Biochem. Pharmacol. 98 (1): 69-77. <a href=\"http:\/\/dx.doi.org\/10.1016\/j.bcp.2015.08.112\">Doi: 10.1016\/j.bcp.2015.08.112<\/a>.<\/li>\n<li>Espina, M., Corte-Rodr\u00edguez, M., Aguado, L., Montes-Bay\u00f3n, M., Sierra, M.I., Mart\u00ednez-Camblor, P., Blanco-Gonz\u00e1lez, E., Sierra, L.M. (2017). Cisplatin resistance in cell models: evaluation of metallomic and biological predictive biomarkers to address early therapy failure. Metallomics 9:564-574. Doi: 10.1039\/c7mt00014f.<\/li>\n<li>Fern\u00e1ndez Asensio, A., T. Iglesias, A. Cotarelo, M. Espina, E. Blanco-Gonz\u00e1lez, L.M. Sierra, M. Montes-Bay\u00f3n (2018).\u00a0 Multiplex polymerase chain reaction in combination with gel electrophoresis-inductively coupled plasma mass spectrometry: A powerful tool for the determination of gene copy number variations and gene expression changes. Analytica Chimica Acta 1023: 64-73. Doi: 10.1016\/j.aca.2018.03.047.<\/li>\n<li>Fern\u00e1ndez Asensio, A., L.M. Sierra, M. Montes-Bay\u00f3n, E. Blanco-Gonz\u00e1lez (2019). Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection. Analytica Chimica Acta 1090:39-46. Doi: 10.1016\/j.aca.2019.09.047.<\/li>\n<li>Zambrano-Andazol, I., N. V\u00e1zquez, M. Chac\u00f3n, R.M. S\u00e1nchez- Avila, M. Persinal, C. Blanco, Z. Gonz\u00e1lez, R. Men\u00e9ndez, M. Sierra, A. Fern\u00e1ndez-Vega, T. S\u00e1nchez, J. Merayo-Lloves, A. Meana (2020). Reduced Graphene Oxide Membranes in Ocular Regenerative Medicine. Materials Science &amp; Engineering C-Mater Biol Appl 114: 111075. Doi: 10.1016\/J.msec.2020.111075.<\/li>\n<li>Fern\u00e1ndez-Villabrille, S., E. \u00c1lvarez-Gonz\u00e1lez, F. Barros, P. De La Pe\u00f1a, L.M. Sierra (2021). Influence of Kv11.1 (hERG1) K+ channel expression on DNA damage induced by the genotoxic agent methyl methanesulfonate. Pflu\u0308gers Archiv &#8211; Eur J Physiol 473:197\u2013217. Doi: 10.1007\/s00424-021-02517-2.<\/li>\n<li>Fern\u00e1ndez Asensio, A, E. Alvarez, A. Rodriguez, L.M. Sierra, E. Blanco-Gonz\u00e1lez (2021). Chromatographic methods coupled to mass spectrometry for the determination of oncometabolites in biological samples-A Review. Analytica Chimica Acta 1177: 338646. Doi: 10.1016\/j.aca.2021.338646.<\/li>\n<li>Fern\u00e1ndez Asensio, A., M. Corte-Rodr\u00edguez, J. Bettmer, L.M. Sierra, M. Montes-Bay\u00f3n, E. Blanco-Gonz\u00e1lez (2021). Targeting HER2 protein in individual cells using ICP-MS detection and its potential as prognostic and predictive breast cancer biomarker. Talanta 235: 122773. Doi: 10.1016\/j.talanta.2021.122773.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"592\" title=\"genotoxicidadTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2660\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27592%27%20viewBox%3D%270%200%20900%20592%27%3E%3Crect%20width%3D%27900%27%20height%3D%27592%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-200x132.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-400x263.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-600x395.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam-800x526.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/genotoxicidadTeam.jpg 900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 900px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and 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fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) 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fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Personnel<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-6\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"250\"><strong>Name<\/strong><\/td>\n<td width=\"300\"><strong>Possition<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Phone<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"250\"><b>Luisa Mar\u00eda Sierra Zapico<\/b><\/td>\n<td width=\"300\">Group leader<\/td>\n<td width=\"252\"><a href=\"mailto:lmsierra@uniovi.es\">lmsierra@uniovi.es<\/a><\/td>\n<td width=\"80\">985102723<\/td>\n<\/tr>\n<tr>\n<td width=\"250\">Enol \u00c1lvarez Gonz\u00e1lez<\/td>\n<td width=\"300\">Predoctoral fellow<\/td>\n<td width=\"252\"><a href=\"mailto:UO239407@uniovi.es\">UO239407@uniovi.es<\/a><\/td>\n<td width=\"80\">985105265<\/td>\n<\/tr>\n<tr>\n<td width=\"250\">Alonso Rodr\u00edguez Pescador<\/td>\n<td width=\"300\">PhD student<\/td>\n<td width=\"252\"><a href=\"mailto:UO278759@uniovi.es\">UO278759@uniovi.es<\/a><\/td>\n<td width=\"80\">985105264<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1492,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1509","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1509"}],"version-history":[{"count":5,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1509\/revisions"}],"predecessor-version":[{"id":2749,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1509\/revisions\/2749"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1492"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}