{"id":1513,"date":"2022-01-31T11:55:50","date_gmt":"2022-01-31T11:55:50","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1513"},"modified":"2023-06-19T11:42:03","modified_gmt":"2023-06-19T09:42:03","slug":"bionuc-biotechnology-of-nutraceuticals-and-bioactive-compounds","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/en\/research\/bionuc-biotechnology-of-nutraceuticals-and-bioactive-compounds\/","title":{"rendered":"BIONUC: Biotechnology of Nutraceuticals and Bioactive Compounds"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>UNIT HEADS<\/strong><br \/>\nFelipe Lomb\u00f3 Brugos<br \/>\n\u00c1ngel Manteca Fern\u00e1ndez<\/p>\n<p><strong>LOCATION<\/strong><br \/>\nDpto. de Biolog\u00eda Funcional. \u00c1rea de Microbiolog\u00eda. Facultad de Medicina. Planta 2\u00aa<\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p><strong>RESEARCH LINES<\/strong><\/p>\n<p>Streptomyces is a very important industrial microorganism, as different species belonging to this genus produce two thirds of clinically relevant secondary metabolites (antibiotics, antitumorals, immunosupressors, etc.).<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div ><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"689\" height=\"320\" title=\"PIB-BIONUC_\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_.png\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_.png\" alt class=\"lazyload img-responsive wp-image-2750\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27689%27%20height%3D%27320%27%20viewBox%3D%270%200%20689%20320%27%3E%3Crect%20width%3D%27689%27%20height%3D%27320%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_-200x93.png 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_-400x186.png 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_-600x279.png 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/PIB-BIONUC_.png 689w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><div style=\"text-align:center;\"><style>.fusion-button.button-1{border-radius:0 0 0 0;}<\/style><a class=\"fusion-button button-flat fusion-button-default-size button-default button-1 fusion-button-default-span \" target=\"_blank\" rel=\"noopener noreferrer\" href=\"http:\/\/bionuc.grupos.uniovi.es\/\"><span class=\"fusion-button-text\">Lab web page<\/span><\/a><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>It is considered as a \u201cmulticellular\u201d prokaryotic model that includes programmed cell death and sporulation in solid cultures. Streptomyces industrial fermentations are mainly produced in liquid cultures (large bioreactors), conditions in which most species do not sporulate, and it was traditionally considered that there was no differentiation.<\/p>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"960\" height=\"389\" title=\"fig1\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1.jpg\" alt class=\"lazyload img-responsive wp-image-1192\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27960%27%20height%3D%27389%27%20viewBox%3D%270%200%20960%20389%27%3E%3Crect%20width%3D%27960%27%20height%3D%27389%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1-200x81.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1-400x162.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1-600x243.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1-800x324.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig1.jpg 960w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 960px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-3\"><p><strong>Fig. 1.\u00a0<em>Streptomyces<\/em>\u00a0developmental cycle in solid (sporulating) and liquid (non-sporulating) cultures.\u00a0<\/strong>New developmental stages described by A. Manteca\u2019s group are highlighted in red. MI, first compartmentalized mycelium, vegetative; MII, second multinucleated mycelium, secondary metabolite-producing mycelium.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p>Our research group defined a new\u00a0<em>Streptomyces<\/em>\u00a0developmental cycle in solid and liquid cultures, identifying by first time, the antibiotic producer mycelium. Understanding the biochemical regulation of differentiation and activation of secondary metabolism is one of the keys for the optimization of hyphae differentiation in industrial fermentations.<\/p>\n<p>Finding new secondary metabolites is becoming critical in biomedicine, and the only way to discover new compounds will be to resume screening from natural strains. The latest discoveries about\u00a0<em>Streptomyces<\/em>\u00a0differentiation are crucial to optimize the screening, reducing the incidence of false negatives.<\/p>\n<p>We have developed different platforms for industrial production of bioactive metabolites in\u00a0<em>S. albus\u00a0<\/em>and<em>\u00a0S. coelicolor<\/em>, as non-ribosomal peptides (the antitumor thiocoraline), sensor peptides for detection of specific cells, and diverse stilbenoids and flavonoids with antitumor and anti-inflammatory activities. These polyphenols are interesting for their use as nutraceuticals and cotherapy bioactive compounds, especially in breast and prostate carcinomas. In both tumors, these nutraceuticals are able to modulate the activity of the estrogen and androgen receptors, inhibiting the growth of these tumors.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"960\" height=\"485\" title=\"Fig2\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2.jpg\" alt class=\"lazyload img-responsive wp-image-1194\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27960%27%20height%3D%27485%27%20viewBox%3D%270%200%20960%20485%27%3E%3Crect%20width%3D%27960%27%20height%3D%27485%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2-200x101.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2-400x202.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2-600x303.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2-800x404.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Fig2.jpg 960w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-5\"><p><strong>Fig. 2.\u00a0<\/strong><strong>Production of biosensor peptides in\u00a0<em>Streptomyces<\/em>:\u00a0<\/strong>tridimensional structure of the fluorescent biosensor protein used for detection of\u00a0<em>E. coli<\/em>\u00a0in drinking water.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><p>We also develop microalgae species as industrial producers of various types of bioactive compounds, mainly antibiotic (for their use as anti-biofilm agents) and antitumor compounds. The objective is to isolate novel bioactive compounds, to discover their biosynthetic pathways, and to generate derivatives with increased pharmacological properties.<\/p>\n<p>Our group also develops strategies for prevention of colorectal cancer. In collaboration with several companies, we developed functional prebiotic meat products, which protect against colorectal carcinoma. These functional foods reduced by 57% the occurrence of colon tumors in an animal models. Results paved the way to further validate functional foods in the prevention of human colon carcinoma.<\/p>\n<\/div><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"960\" height=\"330\" title=\"fig3\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3.jpg\" alt class=\"lazyload img-responsive wp-image-1195\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27960%27%20height%3D%27330%27%20viewBox%3D%270%200%20960%20330%27%3E%3Crect%20width%3D%27960%27%20height%3D%27330%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3-200x69.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3-400x138.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3-600x206.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3-800x275.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/fig3.jpg 960w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 960px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-7\"><p><strong>Fig. 3. Experiments with prebiotic functional foods using an animal model for colon cancer. Left:\u00a0<\/strong>functional food animals show 50% reduction in number of colon tumors, with respect to feed and control food animal groups.\u00a0<strong>Right<\/strong>: functional food animals show 65% reduction in tumor affected colon mucosa area, with respect to feed and control food groups.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 50px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-8\"><p><strong>GROUP HEADS BIOGRAPHIES<\/strong><\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-9\"><p>Felipe Lomb\u00f3 is Doctor in Biology from the University of Oviedo (1998) and Professor at this university since 2008. He has done his research activity mainly in the\u00a0<em>Ruhr-Universit\u00e4t Bochum<\/em>\u00a0(Germany), University of Oviedo and Stanford University (USA), with shorter stays in\u00a0<em>Georg-August Universit\u00e4t G\u00f6ttingen<\/em>\u00a0(Germany),\u00a0<em>Analyticon<\/em>\u00a0AG (Germany), University of S\u00e3o Paulo (Brazil) and The University of Tokyo (Japan). He develops researches related to ultrafast methods of detection of pathogens. However, the main research line focuses on the development of new anti-tumors (bacterial or plant origin), antibiotics (to prevent infection by biofilms) and nutraceuticals (flavonoids, stilbenes, etc.) in bacterial (<em>Streptomyces<\/em>) and microalgae factories, improved by genetic engineering, and scalable (industrial production). Researches include digestive microbiota metagenomics studies, analysing changes associated with functional food intake and its relation to prevent colon carcinoma. He is author of 4 national patents and 3 world patents; two licensed to pharmaceutical and engineering companies.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-10\"><p>Dr. A. Manteca obtained the Biology degree from the University of Oviedo in 2000 and a PhD-degree in Microbiology, in 2005. After a postdoctoral stay at the University of Southern Denmark, working in quantitative mass spectrometry, he returned to the University of Oviedo as a postdoctoral researcher in 2011. The same year, A. Manteca obtained an ERC Starting Grant (STRP-DIFFERENTIATION \u2013 280304), and since January 2012, he is an Associate Professor in the University of Oviedo. The main research line of Dr. Manteca focus in the study of\u00a0<em>Streptomyces<\/em>\u00a0biology, differentiation, and biotechnological applications.\u00a0<em>Streptomyces<\/em>\u00a0is a Gram-positive bacterium characterized by a complex developmental cycle, which is the evolutionary origin of some of the eukaryotic signalling protein domains (apoptotic ATPases, kinases, caspases, nucleases, etc.). In addition, it is a very important industrial bacterium producing two thirds of clinically relevant secondary metabolites (antibiotics, antitumorals, etc.). A. Manteca\u2019s research group was pioneer in the application of new experimental methods to the analysis of\u00a0<em>Streptomyces<\/em>\u00a0biology. At present A. Manteca\u2019s group is applying all this knowledge to the search of new clinical drugs (antibiotics, antitumorals, etc.) from actinomycetes.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-11\"><p><strong>SELECTED PUBLICATIONS<\/strong><\/p>\n<ul>\n<li>Guti\u00e9rrez-Del-R\u00edo I, Brugerolle de Fraissinette N, Castelo-Branco R, Oliveira F, Morais J, Redondo-Blanco S, Villar CJ, Iglesias MJ, Soengas R, Cepas V, Cubillos YL, Sampietro G, Rodolfi L, Lomb\u00f3 F, Gonz\u00e1lez SMS, L\u00f3pez Ortiz F, Vasconcelos V, Reis MA. Chlorosphaerolactylates A-D: Natural Lactylates of Chlorinated Fatty Acids Isolated from the Cyanobacterium Sphaerospermopsis sp. LEGE 00249. J Nat Prod. 2020 Jun 26;83(6):1885-1890.<\/li>\n<li>Gonz\u00e1lez-Qui\u00f1\u00f3nez N, Guti\u00e9rrez-Del-R\u00edo I, Garc\u00eda-Cancela P, Fern\u00e1ndez-Garc\u00eda G, Alonso-Fern\u00e1ndez S, Yag\u00fce P, P\u00e9rez-Valero \u00c1, Montes-Bay\u00f3n M, Lomb\u00f3 F, Manteca \u00c1. The Modulation of SCO2730\/31 Copper Chaperone\/Transporter Orthologue Expression Enhances Secondary Metabolism in Streptomycetes. Int J Mol Sci. 2021 22:10143. doi: 10.3390\/ijms221810143.<\/li>\n<li>Fern\u00e1ndez J, Ledesma E, Monte J, Mill\u00e1n E, Costa P, de la Fuente VG, Garc\u00eda MTF, Mart\u00ednez-Camblor P, Villar CJ, Lomb\u00f3 F. Traditional Processed Meat Products Re-designed Towards Inulin-rich Functional Foods Reduce Polyps in Two Colorectal Cancer Animal Models. Sci Rep. 2019 Oct 15;9(1):14783.<\/li>\n<li>Mar\u00edn L, Guti\u00e9rrez-Del-R\u00edo I, Entrialgo-Cadierno R, Villar CJ, Lomb\u00f3 F. De novo biosynthesis of myricetin, kaempferol and quercetin in Streptomyces albus and Streptomyces coelicolor. PLoS One. 2018 Nov 15;13(11):e0207278.<\/li>\n<li>Rioseras B, Shliaha PV, Gorshkov V, Yag\u00fce P, L\u00f3pez-Garc\u00eda MT, Gonzalez-Qui\u00f1onez N, Kovalchuk S, Rogowska-Wrzesinska A, Jensen ON, Manteca A. Quantitative Proteome and Phosphoproteome Analyses of Streptomyces coelicolor Reveal Proteins and Phosphoproteins Modulating Differentiation and Secondary Metabolism. Mol Cell Proteomics. 2018 17:1591-1611. doi: 10.1074\/mcp.RA117.000515.<\/li>\n<li>Yag\u00fce P, Willemse J, Koning RI, Rioseras B, L\u00f3pez-Garc\u00eda MT, Gonzalez-Qui\u00f1onez N, Lopez-Iglesias C, Shliaha PV, Rogowska-Wrzesinska A, Koster AJ, Jensen ON, van Wezel GP, Manteca \u00c1. (2016) Subcompartmentalization by cross-membranes during early growth of <em>Streptomyces<\/em> Nat Commun. 7:12467.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><style>.fusion-imageframe.imageframe-5{ margin-top : 5px;margin-bottom : 20px;}<\/style><span class=\" fusion-imageframe imageframe-none imageframe-5 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"705\" title=\"bionucTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/bionucTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/bionucTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2672\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27705%27%20viewBox%3D%270%200%20900%20705%27%3E%3Crect%20width%3D%27900%27%20height%3D%27705%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" 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.fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-10{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-10 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-10{width:100% !important;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-10{width:100% !important;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-8 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #e8e8e8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Personnel<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-12\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"179\"><strong>Name<\/strong><\/td>\n<td width=\"108\"><strong>Possition<\/strong><\/td>\n<td width=\"252\"><strong>E-mail<\/strong><\/td>\n<td width=\"80\"><strong>Phone<\/strong><\/td>\n<\/tr>\n<tr>\n<td><b>\u00c1ngel Manteca Fern\u00e1ndez<\/b><\/td>\n<td>PI<\/td>\n<td><a href=\"mailto:mantecaangel@uniovi.es\">mantecaangel@uniovi.es<\/a><\/td>\n<td>985103555<\/td>\n<\/tr>\n<tr>\n<td><b>Felipe Lomb\u00f3 Brugos<\/b><\/td>\n<td>PI<\/td>\n<td><a href=\"mailto:lombofelipe@uniovi.es\">lombofelipe@uniovi.es<\/a><\/td>\n<td>985103593<\/td>\n<\/tr>\n<tr>\n<td>Claudio Jes\u00fas Villar Granja<\/td>\n<td>Associate Prof.<\/td>\n<td><a href=\"mailto:cjvg@uniovi.es\">cjvg@uniovi.es<\/a><\/td>\n<td>985102732<\/td>\n<\/tr>\n<tr>\n<td>Elisa Mar\u00eda Migu\u00e9lez Gonz\u00e1lez<\/td>\n<td>Associate Prof.<\/td>\n<td><a href=\"mailto:emmiguelez@uniovi.es\">emmiguelez@uniovi.es<\/a><\/td>\n<td>985102792<\/td>\n<\/tr>\n<tr>\n<td>Suhui Ye Huang<\/td>\n<td>Postdoct<\/td>\n<td><a href=\"mailto:yesuhui@uniovi.es\">yesuhui@uniovi.es<\/a><\/td>\n<td>Ext 5290<\/td>\n<\/tr>\n<tr>\n<td>Javier Fern\u00e1ndez Fern\u00e1ndez<\/td>\n<td>Postdoct<\/td>\n<td><a href=\"mailto:UO186966@uniovi.es\">UO186966@uniovi.es<\/a><\/td>\n<td>Ext 5290<\/td>\n<\/tr>\n<tr>\n<td>Gemma Fern\u00e1ndez Garc\u00eda<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:gemmafg06@hotmail.com\">gemmafg06@hotmail.com<\/a><\/td>\n<td>Ext 5289<\/td>\n<\/tr>\n<tr>\n<td>Sergio Alonso Fern\u00e1ndez<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:sergioalonsofernandez@gmail.com\">sergioalonsofernandez@gmail.com<\/a><\/td>\n<td>Ext 5289<\/td>\n<\/tr>\n<tr>\n<td>Ignacio Guti\u00e9rrez del R\u00edo Men\u00e9ndez<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:nachogutiem@gmail.com\">nachogutiem@gmail.com<\/a><\/td>\n<td>Ext 5290<\/td>\n<\/tr>\n<tr>\n<td>Patricia Magad\u00e1n Corpas<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:patricia.macor@gmail.com\">patricia.macor@gmail.com<\/a><\/td>\n<td>Ext 5283<\/td>\n<\/tr>\n<tr>\n<td>\u00c1lvaro P\u00e9rez Valero<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:apv.moratalla@gmail.com\">apv.moratalla@gmail.com<\/a><\/td>\n<td>Ext 5283<\/td>\n<\/tr>\n<tr>\n<td>Luis Fern\u00e1ndez Calleja<\/td>\n<td>PhD Student<\/td>\n<td><a href=\"mailto:luiscalleja2010@hotmail.com\">luiscalleja2010@hotmail.com<\/a><\/td>\n<td>Ext 5283<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-11{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-11 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-11{width:100% !important;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-11{width:100% !important;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-8{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1492,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1513","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1513"}],"version-history":[{"count":6,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1513\/revisions"}],"predecessor-version":[{"id":2753,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1513\/revisions\/2753"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1492"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}