{"id":1527,"date":"2022-01-31T12:42:37","date_gmt":"2022-01-31T12:42:37","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?page_id=1527"},"modified":"2023-06-08T12:18:22","modified_gmt":"2023-06-08T10:18:22","slug":"head-and-neck-cancer","status":"publish","type":"page","link":"https:\/\/www.unioviedo.es\/IUOPA\/en\/research\/head-and-neck-cancer\/","title":{"rendered":"Head and Neck Cancer"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"font-size:14px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:14;--minFontSize:14px;line-height:1.3;\"><p><strong>UNIT HEAD<\/strong><br \/>\nProf. Juan Pablo Rodrigo Tapia<\/p>\n<p><strong>LOCATION<\/strong><br \/>\nHospital Universitario Central de Asturias<br \/>\nEdificio FINBA, Planta 0.<br \/>\nAv. Roma SN, 33011 Oviedo<br \/>\nEmail: <a href=\"mailto:jprodrigo@uniovi.es\">jprodrigo@uniovi.es<\/a><\/p><\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#25afb4;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:7px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><p><strong>RESEARCH LINES<\/strong><\/p>\n<p>Our group aims to advance in the knowledge of the processes of tumor initiation, recurrence and metastasis in 3 types of tumors: head and neck squamous cell carcinomas; sinonasal carcinomas; and paragangliomas. It is expected that the achievements will contribute to the discovery of new biomarkers and therapies.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 1;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"120\" height=\"120\" title=\"Foto-JP\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27120%27%20height%3D%27120%27%20viewBox%3D%270%200%20120%20120%27%3E%3Crect%20width%3D%27120%27%20height%3D%27120%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2022\/01\/Foto-JP.jpg\" alt class=\"lazyload img-responsive wp-image-1256\"\/><\/span><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:120px;width:100%;max-width:100px;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 1;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;margin-bottom : 6%;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p><strong>Research Line 1: Squamous cell carcinomas of the head and neck.<\/strong><\/p>\n<ul>\n<li>Biomarkers for early diagnosis and targets for early therapeutic interventions.<\/li>\n<li>Identification of molecular alterations, their relationship with tumor progression and clinical application as biomarkers for diagnosis, prognosis, response to treatment and\/or therapeutic targets.<\/li>\n<li>Role of cancer associated fibroblasts and study of the interaction and communication between tumor cells and between these and the stroma.<\/li>\n<li>Characterization of tumor stem cell (CSC) subpopulations and search for new therapeutic strategies against them.<\/li>\n<\/ul>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><p><strong>Research Line 2: Sinonasal carcinomas<\/strong><\/p>\n<ul>\n<li>Characterize genetic alterations, their prognostic role and as therapeutic targets.<\/li>\n<li>Therapy &#8211; Response to new specific drugs using in vitro and in vivo tumor models.<\/li>\n<li>Tumor invasion and metastasis &#8211; Functional studies using in vitro and in vivo models.<\/li>\n<li>Early detection &#8211; Identifying histological precursor changes and markers of progression to invasive cancer; role of chronic inflammation.<\/li>\n<\/ul>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:50% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 3.84%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 3.84%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><p><strong>Research line 3: Paragangliomas (PGL) and pheochromocytomas (PCC)<\/strong><\/p>\n<ul>\n<li>Identification of genes\/mechanisms involved in the development and evolution of PCC\/PGLs.<\/li>\n<li>Identification of biomarkers to predict the risk of development of multiple PCC\/PGLs, tumor recurrence, and other tumor types in the context of syndromic PCC\/PGLs, as well as in healthy carriers of germline mutations in susceptibility genes.<\/li>\n<li>Identification of therapeutic targets.<\/li>\n<\/ul>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 20px;margin-top : 0px;padding-right : 30px;padding-bottom : 50px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #f8f8f8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><p><strong>GROUP HEAD BIOGRAPHY<\/strong><\/p>\n<p>Juan Pablo Rodrigo Tapia (Guadalajara, 1966) graduated in Medicine from the University of Oviedo (1989), obtaining the End of Career Award. Between 1991-1994 he specialized in Otorhinolaryngology at the HUCA and spent 3 months at the UCLA School of Medicine (CA, USA). In 1995 he obtained his Doctorate in Medicine from the University of Oviedo. He has worked as Otorhinolaryngologist in the hospitals of Le\u00f3n (1995-1998) and HUCA (1998-2008). In 2008 he obtained the position of Associate Professor of Otorhinolaryngology at the University of Oviedo-HUCA, and in 2016 the position of Professor. He is Director of the Department of Surgery and Medical-Surgical Specialties, member of the International Head and Neck Scientific Group. Author of more than 300 scientific publications, he has an H-index of 45, being included in the ranking \u00abTop 2% scientists\u00bb of Stanford University in 2021 and is ranked among the top 10 laryngeal cancer experts in the world.<\/p>\n<p><a href=\"https:\/\/orcid.org\/0000-0003-3063-0890\" target=\"_blank\" rel=\"noopener\">https:\/\/orcid.org\/0000-0003-3063-0890<\/a><\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><p><strong>SELECTED PUBLICATIONS<\/strong><\/p>\n<ul>\n<li>Sanchez-Canteli M, Granda-D\u00edaz R, Del Rio-Ibisate N, Allonca E, L\u00f3pez-Alvarez F, Agorreta J, Garmendia I, Montuenga LM, Garc\u00eda-Pedrero JM, Rodrigo JP. PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas. Cancer Immunol Immunother. 2020 May 24. doi: 10.1007\/s00262-020-02604-w.<\/li>\n<li>Riobello C, L\u00f3pez-Hern\u00e1ndez A, Cabal VN, Garc\u00eda-Mar\u00edn R, Su\u00e1rez-Fern\u00e1ndez L, S\u00e1nchez-Fern\u00e1ndez P, Vivanco B, Blanco V, L\u00f3pez F, Franchi A, Llorente JL, Hermsen MA. IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management. Am J Surg Pathol. 2020 Mar;44(3):396-405. doi: 10.1097\/PAS.0000000000001420.<\/li>\n<li>Lorenzo-Mart\u00edn LF, Fern\u00e1ndez-Parejo N, Menacho-M\u00e1rquez M, Rodr\u00edguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, Garc\u00eda-Pedrero JM, Abad A, Garc\u00eda-Mac\u00edas MC, Gonz\u00e1lez N, Lorenzano-Menna P, Pav\u00f3n MA, Gonz\u00e1lez-Sarmiento R, Segrelles C, Paramio JM, Tub\u00edo JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038\/s41467-020-18524-3.<\/li>\n<li>Garmendia I, Pajares MJ, Hermida-Prado F, Ajona D, B\u00e9rtolo C, Sainz C, Lav\u00edn A, Rem\u00edrez AB, Valencia K, Moreno H, Ferrer I, Behrens C, Cuadrado M, Paz-Ares L,Bustelo XR, Gil-Bazo I, Alameda D, Lecanda F, Calvo A, Felip E, S\u00e1nchez-C\u00e9spedesM, Wistuba II, Granda-Diaz R, Rodrigo JP, Garc\u00eda-Pedrero JM, Pio R, Montuenga LM,Agorreta J. YES1 Drives Lung Cancer Growth and Progression and PredictsSensitivity to Dasatinib. Am J Respir Crit Care Med. 2019 Oct 1;200(7):888-899.doi: 10.1164\/rccm.201807-1292OC.<\/li>\n<li>Hermsen MA, Riobello C, Garc\u00eda-Mar\u00edn R, Cabal VN, Su\u00e1rez-Fern\u00e1ndez L, L\u00f3pez F,Llorente JL. Translational genomics of sinonasal cancers. Semin Cancer Biol. 2019Sep 24. pii: S1044-579X(19)30306-2. doi: 10.1016\/j.semcancer.2019.09.016.<\/li>\n<li>Hermida-Prado F, Granda-D\u00edaz R, Del-R\u00edo-Ibisate N, Villaronga M\u00c1, Allonca E, Garmendia I, Montuenga LM, Rodr\u00edguez R, Vallina A, Alvarez-Marcos C, Rodrigo JP, Garc\u00eda-Pedrero JM. The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2019 Oct 25;11(11):1644. doi: 10.3390\/cancers11111644.<\/li>\n<li>Bernardo-Casti\u00f1eira C, Vald\u00e9s N, Celada L, Martinez ASJ, S\u00e1enz-de-Santa-Mar\u00edaI, Bay\u00f3n GF, Fern\u00e1ndez AF, Sierra MI, Fraga MF, Astudillo A, Jim\u00e9nez-Fonseca P,Rial JC, Hevia M\u00c1, Turienzo E, Bernardo C, Forga L, Tena I, Molina-Garrido MJ,Cacho L, Villabona C, Serrano T, Scola B, Chirivella I, Del Olmo M, Men\u00e9ndez CL, Navarro E, Tous M, Vallejo A, Athimulam S, Bancos I, Suarez C, Chiara MD.Epigenetic Deregulation of Protocadherin PCDHGC3 inPheochromocytomas\/Paragangliomas Associated With SDHB Mutations. J ClinEndocrinol Metab. 2019 Nov 1;104(11):5673-5692. doi: 10.1210\/jc.2018-01471.<\/li>\n<li>Bernardo-Casti\u00f1eira C, Vald\u00e9s N, Sierra MI, S\u00e1enz-de-Santa-Mar\u00eda I, Bay\u00f3n GF, Perez RF, Fern\u00e1ndez AF, Fraga MF, Astudillo A, Men\u00e9ndez R, Fern\u00e1ndez B, Del Olmo M, Suarez C, Chiara MD. SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas. J Clin Endocrinol Metab. 2018 Jan 1;103(1):295-305. doi: 10.1210\/jc.2017-01702.<\/li>\n<li>Llanos S, Garc\u00eda-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M. Stabilization of p21 by mTORC1\/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438<\/li>\n<li>Llorente JL, L\u00f3pez F, Su\u00e1rez C, Hermsen MA.Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances. Nat Rev Clin Oncol. 2014;11:460-72.<\/li>\n<\/ul>\n<\/div><div style=\"text-align:center;\"><style>.fusion-imageframe.imageframe-2{ margin-top : 10px;margin-bottom : 30px;}<\/style><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"900\" height=\"578\" title=\"oncologiaTeam\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam.jpg\" alt class=\"lazyload img-responsive wp-image-2699\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27900%27%20height%3D%27578%27%20viewBox%3D%270%200%20900%20578%27%3E%3Crect%20width%3D%27900%27%20height%3D%27578%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam-200x128.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam-400x257.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam-600x385.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam-800x514.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2023\/06\/oncologiaTeam.jpg 900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 900px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-section-separator section-separator triangle fusion-section-separator-1\"><div class=\"fusion-section-separator-svg\" style=\"border-bottom:1px solid #f8f8f8;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #f8f8f8;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #f8f8f8;border-left:1px solid #f8f8f8;\"><\/div><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\" style=\"height:1px;\"><\/div><\/div><style type=\"text\/css\">.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}@media only screen and (max-width:1024px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}@media only screen and (max-width:640px) {.fusion-section-separator-1 .fusion-section-separator-svg {margin-left:1.92%;margin-right:1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #e8e8e8;background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:31px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"font-size:60px;margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;color:#ffffff;--fontSize:60;line-height:1.3;\">Personnel<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;max-width:100px;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#ffffff;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-7\"><table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"250\"><strong>Name<\/strong><\/td>\n<td width=\"300\"><strong>Position<\/strong><\/td>\n<td width=\"100\"><strong>E-mail<\/strong><\/td>\n<td width=\"200\"><strong>Phone<\/strong><\/td>\n<\/tr>\n<tr>\n<td><b>Rodrigo Tapia, Juan Pablo<\/b><\/td>\n<td>Catedr\u00e1tico Vinculado Jefe de Grupo<\/td>\n<td><a href=\"mailto:jprodrigo@uniovi.es\">jprodrigo@uniovi.es<\/a><\/td>\n<td>985 10 80 00 Extt\/38140<\/td>\n<\/tr>\n<tr>\n<td>Llorente Pend\u00e1s, Jos\u00e9 Luis<\/td>\n<td>Catedr\u00e1tico Vinculado Jefe de Servicio cl\u00ednico<\/td>\n<td><a href=\"mailto:jllorente@uniovi.es\">jllorente@uniovi.es<\/a><\/td>\n<td>985 10 80 00 Extt\/38140<\/td>\n<\/tr>\n<tr>\n<td>\u00c1lvarez Marcos, Cesar<\/td>\n<td>Profesor Titular Vinculado<\/td>\n<td><a href=\"mailto:alvarezmarcos@telefonica.net\">alvarezmarcos@telefonica.net<\/a><\/td>\n<td>985 10 80 00 Ext.38140<\/td>\n<\/tr>\n<tr>\n<td>L\u00f3pez \u00c1lvarez, Fernando<\/td>\n<td>M\u00e9dico adjunto profesor asociado ORL<\/td>\n<td><a href=\"mailto:flopez_1981@yahoo.es\">flopez_1981@yahoo.es<\/a><\/td>\n<td>985 10 80 00 Ext\/38140<\/td>\n<\/tr>\n<tr>\n<td>N\u00fa\u00f1ez Batalla, Faustino<\/td>\n<td>M\u00e9dico adjunto \/profesor asociado ORL<\/td>\n<td><a href=\"mailto:fnunezb@telefonica.net\">fnunezb@telefonica.net<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Coca Pelaz, Andr\u00e9s<\/td>\n<td>M\u00e9dico adjunto \/ profesor asociado ORL<\/td>\n<td><a href=\"mailto:acocapelaz@yahoo.es\">acocapelaz@yahoo.es<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Suarez Fente, Vanessa<\/td>\n<td>M\u00e9dico adjunto ORL<\/td>\n<td><a href=\"mailto:vannexasf@yahoo.es\">vannexasf@yahoo.es<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>S\u00e1nchez Fern\u00e1ndez, Rafael<\/td>\n<td>M\u00e9dico adjunto ORL<\/td>\n<td><a href=\"mailto:rafasanchez.mail@gmail.com\">rafasanchez.mail@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Garc\u00eda-Cabo Herrero, Patricia<\/td>\n<td>M\u00e9dico adjunto ORL<\/td>\n<td><a href=\"mailto:patty.gcabo@gmail.com\">patty.gcabo@gmail.com<\/a><\/td>\n<td>985 10 80 00 Ext\/38140<\/td>\n<\/tr>\n<tr>\n<td>Vivanco Allende, Blanca<\/td>\n<td>M\u00e9dico adjunto \/ profesor asociado A. Patol\u00f3gica<\/td>\n<td><a href=\"mailto:vivancoblanca@gmail.com\">vivancoblanca@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Santos-Juanes Jimenez, Jorge<\/td>\n<td>Profesor Titular Vinculado Dermatolog\u00eda<\/td>\n<td><a href=\"mailto:jorgesantosjuanes@gmail.com\">jorgesantosjuanes@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Chiara Romero, M\u00aa Dolores<\/td>\n<td>Investigador Senior I3 SNS \/ Profesor titular en excedencia<\/td>\n<td><a href=\"mailto:mdchiara.uo@uniovi.es\">mdchiara.uo@uniovi.es<\/a><\/td>\n<td>985 10 80 00 Ext\/37956<\/td>\n<\/tr>\n<tr>\n<td>Garc\u00eda Pedrero, Juana Mar\u00eda<\/td>\n<td>Investigador Senior \/ estabilizado FINBA<\/td>\n<td><a href=\"mailto:garpe20002000@yahoo.es\">garpe20002000@yahoo.es<\/a><\/td>\n<td>985 10 80 00 Ext\/37937<\/td>\n<\/tr>\n<tr>\n<td>Hermsen, Marinus A.J.A.<\/td>\n<td>Investigador Senior I3 SNS<\/td>\n<td><a href=\"mailto:mhermsen@hca.es\">mhermsen@hca.es<\/a><\/td>\n<td>985 10 80 00 Ext\/37937<\/td>\n<\/tr>\n<tr>\n<td>\u00c1lvarez Fern\u00e1ndez, M\u00f3nica<\/td>\n<td>Investigador AECC. Alta en Diciembre 2019<\/td>\n<td><a href=\"mailto:maf.finba@gmail.com\">maf.finba@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Garc\u00eda Mar\u00edn, Roc\u00edo<\/td>\n<td>Postdoctoral<\/td>\n<td><a href=\"mailto:rociogm@us.es\">rociogm@us.es<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Granda D\u00edaz, Roc\u00edo<\/td>\n<td>Doctorando \/ Beca Severo Ochoa<\/td>\n<td><a href=\"mailto:rocigd281@gmail.com\">rocigd281@gmail.com<\/a><\/td>\n<td>985 10 80 00 Ext\/38860<\/td>\n<\/tr>\n<tr>\n<td>Del R\u00edo Ibisate, Nagore<\/td>\n<td>Doctorando \/ Beca FPU<\/td>\n<td><a href=\"mailto:nagoredelrio@gmail.com\">nagoredelrio@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Celada Crespo, Luc\u00eda<\/td>\n<td>Doctorando \/ Beca FPU<\/td>\n<td><a href=\"mailto:celadalucia@hotmail.com\">celadalucia@hotmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pedregal Mallo, Daniel<\/td>\n<td>M\u00e9dico adjunto ORL \/ Doctor<\/td>\n<td><a href=\"mailto:pedregal.dm@gmail.com\">pedregal.dm@gmail.com<\/a><\/td>\n<td>985 10 80 00 Ext\/38140<\/td>\n<\/tr>\n<tr>\n<td>Men\u00e9ndez Castro, Marta<\/td>\n<td>M\u00e9dico adjunto \/ doctorando<\/td>\n<td><a href=\"mailto:marmdc210@gmail.com\">marmdc210@gmail.com<\/a><\/td>\n<td>985 10 80 00 Ext\/38140<\/td>\n<\/tr>\n<tr>\n<td>S\u00e1nchez Fern\u00e1ndez, Paula<\/td>\n<td>M\u00e9dico adjunto de ORL \/ Doctor<\/td>\n<td><a href=\"mailto:sfernan90@hotmail.com\">psfernan90@hotmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>S\u00e1nchez Canteli, Mario<\/td>\n<td>M\u00e9dico residente \/ doctorando<\/td>\n<td><a href=\"mailto:mariosanchezcanteli@gmail.com\">mariosanchezcanteli@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Grobas Alvarez, Jaime<\/td>\n<td>M\u00e9dico residente \/ doctorando<\/td>\n<td><a href=\"mailto:jaime.g.r@hotmail.com\">jaime.g.r@hotmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Casanueva Muruais, Rodrigo<\/td>\n<td>M\u00e9dico residente \/ doctorando<\/td>\n<td><a href=\"mailto:casanuevamuruais@gmail.com\">casanuevamuruais@gmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Villanueva Fern\u00e1ndez, Eva<\/td>\n<td>M\u00e9dico residente \/ doctorando<\/td>\n<td><a href=\"mailto:evaviva12@hotmail.com\">evaviva12@hotmail.com<\/a><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Naves Cabal, Virginia<\/td>\n<td>T\u00e9cnico FP<\/td>\n<td><a href=\"mailto:vircabal@hotmail.com\">vircabal@hotmail.com<\/a><\/td>\n<td>985 10 80 00 Ext\/38860<\/td>\n<\/tr>\n<tr>\n<td>Saul Alvarez Teijeiro<\/td>\n<td>Contrato Sara Borrell<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Francisco Hermida Prado<\/td>\n<td>Contrato Mar\u00eda Zambrano<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Sof\u00eda Tirados Menendez<\/td>\n<td>Postdoctoral con cargo a proyecto<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Miguel Alvarez Gonzalez<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Tamara Cubiella Victorero<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Sara Lucila Lorenzo Guerra<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Irene Montoro Jimenez<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Esperanza Pozo Agundo<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Llara Prieto Fern\u00e1ndez<\/td>\n<td>Predoctoral<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-7{ padding-top : 70px;margin-top : 0px;padding-right : 30px;padding-bottom : 70px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1492,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1527","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=1527"}],"version-history":[{"count":8,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1527\/revisions"}],"predecessor-version":[{"id":2701,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1527\/revisions\/2701"}],"up":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/pages\/1492"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=1527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}