{"id":4189,"date":"2025-04-29T14:21:22","date_gmt":"2025-04-29T12:21:22","guid":{"rendered":"https:\/\/www.unioviedo.es\/IUOPA\/?p=4189"},"modified":"2025-04-29T14:22:17","modified_gmt":"2025-04-29T12:22:17","slug":"mitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis","status":"publish","type":"post","link":"https:\/\/www.unioviedo.es\/IUOPA\/mitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis\/","title":{"rendered":"Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"font-size:30px;margin-top:0px;margin-right:0px;margin-bottom:20px;margin-left:0px;\"><h1 class=\"title-heading-left fusion-responsive-typography-calculated\" style=\"margin:0;font-size:1em;--fontSize:30;line-height:1.1;\">Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis<\/h1><\/div><div ><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-zoomin\"><a href=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-scaled.jpg\" class=\"fusion-lightbox\" data-rel=\"iLightbox[8576cdbdd62f5eaab16]\" data-title=\"bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash\" title=\"bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash\"><img decoding=\"async\" width=\"2560\" height=\"1443\" src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-scaled.jpg\" data-orig-src=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-scaled.jpg\" alt class=\"lazyload img-responsive wp-image-4192\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271443%27%20viewBox%3D%270%200%202560%201443%27%3E%3Crect%20width%3D%272560%27%20height%3D%271443%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-200x113.jpg 200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-400x226.jpg 400w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-600x338.jpg 600w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-800x451.jpg 800w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-1200x677.jpg 1200w, https:\/\/www.unioviedo.es\/IUOPA\/wp-content\/uploads\/2025\/04\/bioscience-image-library-by-fayette-reynolds-rVG2ADmYf8Q-unsplash-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 1200px\" \/><\/a><\/span><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-1\"><h5>Gozdecka M, Dudek M, Wen S, Gu M, Stopforth RJ, Rak J, Damaskou A, Grice GL, McLoughlin MA, Bond L, Wilson R, Giotopoulos G, Mahalingam Shanmugiah V, Bakar RB, Yankova E, Cooper JL, Narayan N, Horton SJ, Asby R, Pask DC, Mupo A, Duddy G, Marando L, Georgomanolis T, Carter P, Ramesh AP, Dunn WG, Barcena C, Gallipoli P, Yusa K, Petrovski S, Wright P, Quiros PM, Frezza C, Nathan JA, Kaser A, Kar S, Tzelepis K, Mitchell J, Fabre MA, Huntly BJP, Vassiliou GS.<\/h5>\n<h6>Nature. 2025 Apr 16. doi: 10.1038\/s41586-025-08980-6. Online ahead of print.<\/h6>\n<h6>PMID: 40239706<\/h6>\n<\/div><div class=\"fusion-text fusion-text-2\"><p>La revista<strong> National Library of Medicine<\/strong><em> (National Center for Biotechnology Information)<\/em> se ha hecho eco del trabajo del Grupo <strong>Biolog\u00eda Molecular del C\u00e1ncer<\/strong>\u00a0con participaci\u00f3n de la doctora <strong>Clea Barcena Fern\u00e1ndez<\/strong><strong>\u00a0<em>(<a href=\"mailto:barcenaclea@uniovi.es\">barcenaclea@uniovi.es<\/a>).<\/em><\/strong><\/p>\n<p><b>Consulta la publicaci\u00f3n en el siguiente <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40239706\/\" target=\"_blank\" rel=\"noopener\">enlace<\/a><\/b><\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:75% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.56%;margin-left : 2.56%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 80px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 20px 0px 20px 0px;\"><div class=\"fusion-sharing-box fusion-sharing-box-1\" style=\"background-color:#f6f6f6;margin-top:60px;\" data-title=\"Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis\" data-description=\"Gozdecka M, Dudek M, Wen S, Gu M, Stopforth RJ, Rak J, Damaskou A, Grice GL, McLoughlin MA, Bond L, Wilson R, Giotopoulos G, Mahalingam Shanmugiah V, Bakar RB, Yankova E, Cooper JL, Narayan N, Horton SJ, Asby R, Pask DC, Mupo A, Duddy G, Marando L, Georgomanolis T, Carter P, Ramesh AP,\" data-link=\"https:\/\/www.unioviedo.es\/IUOPA\/mitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis\/\"><h4 class=\"tagline\" style=\"color:#2f2f2f;\">Compartir noticia<\/h4><div class=\"fusion-social-networks sharingbox-shortcode-icon-wrapper sharingbox-shortcode-icon-wrapper-1\"><span><a href=\"https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fwww.unioviedo.es%2FIUOPA%2Fmitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis%2F&amp;t=Mitochondrial%20metabolism%20sustains%20DNMT3A-R882-mutant%20clonal%20haematopoiesis\" target=\"_blank\" rel=\"noreferrer\" title=\"Facebook\" aria-label=\"Facebook\"><i class=\"fusion-social-network-icon fusion-tooltip fusion-facebook awb-icon-facebook\" style=\"color:#76b5ae;\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/twitter.com\/share?text=Mitochondrial%20metabolism%20sustains%20DNMT3A-R882-mutant%20clonal%20haematopoiesis&amp;url=https%3A%2F%2Fwww.unioviedo.es%2FIUOPA%2Fmitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis%2F\" target=\"_blank\" rel=\"noopener noreferrer\" title=\"Twitter\" aria-label=\"Twitter\"><i class=\"fusion-social-network-icon fusion-tooltip fusion-twitter awb-icon-twitter\" style=\"color:#76b5ae;\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.linkedin.com\/shareArticle?mini=true&amp;url=https%3A%2F%2Fwww.unioviedo.es%2FIUOPA%2Fmitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis%2F&amp;title=Mitochondrial%20metabolism%20sustains%20DNMT3A-R882-mutant%20clonal%20haematopoiesis&amp;summary=Gozdecka%20M%2C%20Dudek%20M%2C%20Wen%20S%2C%20Gu%20M%2C%20Stopforth%20RJ%2C%20Rak%20J%2C%20Damaskou%20A%2C%20Grice%20GL%2C%20McLoughlin%20MA%2C%20Bond%20L%2C%20Wilson%20R%2C%20Giotopoulos%20G%2C%20Mahalingam%20Shanmugiah%20V%2C%20Bakar%20RB%2C%20Yankova%20E%2C%20Cooper%20JL%2C%20Narayan%20N%2C%20Horton%20SJ%2C%20Asby%20R%2C%20Pask%20DC%2C%20Mupo%20A%2C%20Duddy%20G%2C%20Marando%20L%2C%20Georgomanolis%20T%2C%20Carter%20P%2C%20Ramesh%20AP%2C\" target=\"_blank\" rel=\"noopener noreferrer\" title=\"LinkedIn\" aria-label=\"LinkedIn\"><i class=\"fusion-social-network-icon fusion-tooltip fusion-linkedin awb-icon-linkedin\" style=\"color:#76b5ae;\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"mailto:?subject=Mitochondrial%20metabolism%20sustains%20DNMT3A-R882-mutant%20clonal%20haematopoiesis&amp;body=https%3A%2F%2Fwww.unioviedo.es%2FIUOPA%2Fmitochondrial-metabolism-sustains-dnmt3a-r882-mutant-clonal-haematopoiesis%2F\" target=\"_self\" title=\"Correo electr\u00f3nico\" aria-label=\"Correo electr\u00f3nico\"><i class=\"fusion-social-network-icon fusion-tooltip fusion-mail awb-icon-mail\" style=\"color:#76b5ae;\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div><\/div><style type=\"text\/css\">.fusion-sharing-box-1 h4{margin-bottom:0 !important;}.fusion-sharing-box-1{flex-direction:row !important;padding-top:20px !important;padding-bottom:20px !important;}.sharingbox-shortcode-icon-wrapper-1 span.sharingbox-shortcode-icon-separator{border-right-width:0px !important;}@media only screen and (max-width:1024px){.fusion-sharing-box-1 h4{margin-right:0.5em !important;margin-bottom:0 !important;}.sharingbox-shortcode-icon-wrapper-1{width:auto !important;justify-content:flex-end !important;}.fusion-sharing-box-1{align-items:center !important;} }@media only screen and (max-width:640px){.fusion-sharing-box-1{flex-direction: column !important;align-items:center !important;}.fusion-sharing-box-1 h4{margin-bottom:revert !important;}.sharingbox-shortcode-icon-wrapper-1{width:100% !important;justify-content:space-between !important;} }<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 20px !important;padding-right : 0px !important;margin-right : 1.92%;padding-bottom : 20px !important;padding-left : 0px !important;margin-left : 1.92%;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 0px;margin-top : 0px;padding-right : 30px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 30px;}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4192,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,241],"tags":[19],"class_list":["post-4189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicaciones","category-ultimas-noticias","tag-actualidad-iuopa"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/posts\/4189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/comments?post=4189"}],"version-history":[{"count":2,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/posts\/4189\/revisions"}],"predecessor-version":[{"id":4191,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/posts\/4189\/revisions\/4191"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media\/4192"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/media?parent=4189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/categories?post=4189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unioviedo.es\/IUOPA\/wp-json\/wp\/v2\/tags?post=4189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}