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Massimo Collino
Associate Professor of Pharmacology
SALIVAGES PI and Coordinator
Born in Pinerolo (TO, Italy) – 19th January 1973
Current Position: 2014 Associate Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy).
2017: National Scientific Habilitation as Full Professor of Pharmacology (05/G1, Pharmacology)
Education:
1998: Bachelor Degree in Pharmaceutical Chemistry and Technology at the University of Turin, Faculty of Pharmacy,: summa cum laude.
31/12/2003: Ph. D. in “Pharmacology and Toxicology” 2003 – 2004 Visiting Scientist at The William Harvey Research Institute, Centre for Experimental Medicine, Nephrology & Critical Care, Barts and The
London, Queen Mary’s School of Medicine and Dentistry, London (UK)
2002 -2014 Assistant Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy)
Scientific Activity:
Author of 90 full papers published in international journals with Impact Factor; 50 Proceedings published in international journals with Impact Factor; 3 Book chapters Citations: 1886 total citations h-index: 26
Current research interests:
Pathophysiology and the pharmacological therapy of diet-induced metabolic disorders and the related cardiovascular risk factors, mainly organ-related ischemic events. Specifically, development of innovative experimental in vivo models and molecular, biochemical and analytical methods for investigating the impact of diets and selective food components on the activation of selective inflammatory pathways (e.g. NF-kB, NLRP3 inflammasome, JAK-STAT, BTK) and the accumulation of Advanced Glycation End Products. Most recent research activity has been focused on the validation of the NLRP3 “inflammasome,” a multiprotein complex leading to the processing and secretion of the proinflammatory cytokines interleukin- (IL-)1beta and IL- 18, as pharmacological target for cardiometabolic diseases.
Five most relevant publications and/or active involvement in relevant projects:
- European Coordinator of the European Project “Innovative Technological Approaches for validation of Salivary AGEs as novel biomarkers in evaluation of risk factors for diet-related diseases”, ERA-HDHL Transnational Call «Biomarkers for Nutrition and Health», 2017-2020
- Member of the Organizing Commettee of European Congresses on Health and Nutrition (e.g. 8th Euro Global Diabetes Summit and Medicare Expo, November 3-5, 2015 at Valencia, Spain; 10th European Diabetes Congress, July 14-16, 2016 at Cologne, Germany; International Conference on Nutrition, Health and Aging, September 26-28, 2018 at Frankfurt, Germany; Euro Nutrition 2018, October 18-20, 2018 Paris, France)
- Guest Editor for a Special Issue on the Journal «Oxidative Medicine and Cellular Longevity” (ISSN: 1942-0900). Title Special Issue: “Gut Microbiota and Oxidative Stress: Implications in Cardiovascular Disease”, 2018
- Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento AS, Collotta D, Querio G, Nigro D, Bitonto V, Cutrin JC, Rantsiou K, Durante M, Masini E, Aragno M, Cordero C, Cocolin L, Collino M. Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study. J Nutr Biochem. 2018 Feb 13;55:185-199. doi: 10.1016/j.jnutbio.2018.02.003
- Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M. Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice. Mol Med. 2015; 21(1):1025-1037. doi: 10.2119/molmed.2015.00104.
Fausto Chiazza
Postdoctoral Researcher
Debora Collotta
PhD student
Chiara Emilia Irma Cordero
Associate Professor of Food Chemistry
Chiara Cordero since November 2014 is Associate Professor of Food Chemistry (CHIM/10 – Food Chemistry) at the Dipartimento di Scienza e Tecnologia del Farmaco of the University of Turin.
In 2008 Dr. Cordero received a fellowship from Fondazione CRT, project «World Wide Style Mobilità in Uscita» and spent a research period at the Deutsche Forschungsanstalt für Lebensmittelchemie – DFA (German Research Center for Food Chemistry) at the Lehrstuhls für Lebensmittelchemie der Technischen Universität München – Garching (Germany) under the supervision of Prof. Peter Schieberle. The research activity was focused on the Sensomic approach to food characterization.
In 2008, she was awarded with the «Leslie S. Ettre Award for the young scientist who presented the most interesting original research in capillary gas chromatography with an emphasis on environmental and food safety» during the 32nd International Symposium on Capillary Chromatography (ISCC) and 5th GCxGC Symposium (26-30 May, 2008).
In 2014 received the John B. Phillips Award for her research activity in the GC×GC field and in 2016 was included in the list of Top 50 most influential women in the analytical sciences – The Analytical Scientist 2016 The Power List (https://theanalyticalscientist.com/power-list/2016/).
Research interests focus on: (a) development of innovative and advanced instrumental configurations for GC×GC coupled to Mass Spectrometric detection (MS) for food-omics including profiling and fingerprinting approaches; (b) discovery of food intake markers (low molecular weight metabolites, Advanced Glycation End-products and volatiles in bio-fluids) and metabolic fineprint after diet induced derangements; (c) development and application of miniaturized, fully automated and solvent-free approaches (Solid Phase Microextraction SPME, Stir Bar Sorptive Extraction SBSE) for sensomics characterization of food.
Chiara Cordero actively collaborates with several foreign institutions:
- Deutsche Forschungsanstalt für Lebensmittelchemie – DFA (German Research Center for Food Chemistry) – Technical University of Munich – Prof. Peter Schieberle and Prof. Thomas Hofmann.
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Computer Science and Engineering Department, University of Nebraska, Lincoln, NE USA – Prof. Stephen Reichenbach.
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Institut für Sicherheit und Qualität bei Obst und Gemüse – Max Rubner-Institut – Bundesforschungsinstitut für Ernährung und Lebensmittel Karlsruhe Germania – Dr. Sabine Kulling and Christoph Weinert.
Collaborations with private companies for applied research and technology transfer
- Ferrero- Soremartec Italia – Alba (CN): high quality food characterization and qualification though functional and active compounds.
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Firmenich SA – Geneva Switzerland: characterization of high quality food by innovative multidimensional gas chromatographic platforms: fingerprinting and profiling by advanced data elaboration processes. Suspected volatile allergens in raw materials for cosmetic products: development and optimization of GC×GC-MS/FID platforms for quantitative surveys and detailed profiling.
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Agilent Technologies – Wilmington USA: application partnership for reverse-inject differential flow modulated GC×GC. Prototypes evaluation and testing, application development in the field of flavors and fragrances.
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Zoex Europe – Advanced GC×GC Scientific Board: member of the advisory board supporting training activities and application development in flavor and fragrance fields.
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SRA Italy – Cernusco sul Naviglio (MI): GC×GC-MS solution development for high throughput analysis on the field of volatiles profiling and fingerprinting. Development of new and innovative GC×GC configurations by thermal modulators and differential flow modulators.
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Markes International Ltd Llantrisant UK: application partnership for the Time of Flight Mass Spectrometric Detection with hard and soft ionization. ToF-MS hyphenation with GC×GC for advanced fingerprinting of complex samples.
Erica Liberto
Assistant Professor of Food Chemistry
Manuela Aragno
Associate Professor
1983 Graduated in Biological Science (108/110)
1985 Research fellow by Piedmont Region
1990 PhD in Experimental Medicine, University of Turin
1991 Technician Assistent in Dept Experimental Medicine and Oncology, University of Turin.
2001 PhD Researcher, Faculty of Medicine and Surgery, University of Turin.
2006 PhD Associated Professor in Pathology, Faculty of Medicine and Surgery University of Turin
2016 Participate in the procedure for obtaining the national scientific qualification as full professor with positive opinion.
University courses:
Pathology and Pathophysiology Microscope Training Course in Medicine and Surgery University of Turin; Pathology and Physiopathology Course, Nurse Degree, University of Turin with location in Turin, Ivrea and Aosta from academic years 2000.
Research funds: Piedmont Region; PRIN; San Paolo Foundation, Turin University Found ex 60%, CRT Foundation.
Affiliation: Italian Society of Pathology, SFFR (Society for Free Radical Research), Italian Society of Cardiovascular Research.
Academic appointments:
Secretary of Medicine Degree Course of Turin University 2010-2013;
Secretary of Nurse Degree Course of Turin University 2010-2013;
Member of President Council of Nurse Degree Course of Turin 2010-2018;
Member of “Commissione Consultiva Paritetica Permanente and Consiglio di Presidenza” of Nurse Degree Course of Aosta;
Member of Doctoral School in «Medicine and Experimental Therapy»;
Member of “Didattica” Commission of Clinical and Biological Science Department 2015-2018;
Coordinator of Pathology and Physiopathology Course in Nurse Degree Course of Turin, Ivrea and Aosta university.
Author of 156 publications
Publications with IF: 97
Congress articles: 56
h-index: 34
Number of citations: 3625
Research study.
The main fields of the research have been performed on pathogenesis of tissue damage by oxidative stress, in particular about: pathogenesis of liver injuries following mixtures of halogen-compounds; steroids and oxidative pathways, specially in the complications of diabetes and in Alzheimer diseases. In the last years, the studies has been addressed on high caloric diet and metabolic disorders on tissue target as well as liver, heart and brain with particular attention on pharmacological characterisation of peroxisome proliferators activated receptors in experimental animal models. Mainly attention is turned towards the identification and the classification of advanced end products derived from high caloric diet indicated as relevant and emergent risk factors for cardiometabolic disease.
Raffaella Mastrocola
Personale Tecnico Amministrativo
Alessia Sofia Centro
PhD student
