{"id":2408,"date":"2023-02-22T11:44:53","date_gmt":"2023-02-22T10:44:53","guid":{"rendered":"https:\/\/www.unioviedo.es\/gelp\/?p=2408"},"modified":"2023-02-22T12:11:05","modified_gmt":"2023-02-22T11:11:05","slug":"collaboration_paper_nature","status":"publish","type":"post","link":"https:\/\/www.unioviedo.es\/gelp\/collaboration_paper_nature\/","title":{"rendered":"Collaboration paper featuring Ana M\u00e9ndez and Jorge Pisonero published by Nature Communications!"},"content":{"rendered":"

Collaboration paper <\/span><\/h2>\n

Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy <\/strong><\/span><\/h2>\n

featuring Ana M\u00e9ndez and Jorge Pisonero from the University of Oviedo<\/span> was accepted by Nature Communications <\/a>!\u00a0<\/span><\/span><\/p>\n

Abstract<\/h4>\n

A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genetic program induced by oxaliplatin-based CT in the tumor microenvironment. We show that oxaliplatin is largely retained by cancer-associated fibroblasts (CAFs) long time after the treatment ceased. We determine that CT accumulation in CAFs intensifies TGF-beta activity, leading to the production of multiple factors enhancing cancer aggressiveness. We establish periostin as a stromal marker of chemotherapeutic activity intrinsically upregulated in consensus molecular subtype 4 (CMS4) tumors and highly expressed before and\/or after treatment in patients unresponsive to therapy. Collectively, our study underscores the ability of CT-retaining CAFs to support cancer progression and resistance to treatment.<\/p><\/blockquote>\n

\"\"
The University of Oviedo carried out imaging of Pt concentration in tissue samples<\/figcaption><\/figure>\n

This outsanding work is the result of a collaboration involvnig several institutions:<\/p>\n

    \n
  • \n

    Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Department of Medical Oncology, Catalan Institute of Oncology (ICO), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Department of Physics, Faculty of Science, University of Oviedo, Oviedo, Spain<\/strong><\/p>\n<\/li>\n

  • \n

    Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain<\/p>\n<\/li>\n

  • \n

    Department of Pathology, Hospital Cl\u00ednico Universitario, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain<\/p>\n<\/li>\n

  • \n

    Department of Medical Oncology, Hospital Cl\u00ednico Universitario, INCLIVA Biomedical Research Institute, University of Valencia, Valencia, Spain<\/p>\n<\/li>\n

  • \n

    Medical Oncology Department, Hospital del Mar, Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Vall d\u2019Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Institut d\u2019Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Unidad Asociada IIBB-CSIC, Barcelona, Spain<\/p>\n<\/li>\n

  • \n

    Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain<\/p>\n

    \n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Collaboration paper Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy featuring Ana M\u00e9ndez and Jorge Pisonero from the University of Oviedo was accepted by Nature Communications !\u00a0 Abstract A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. […]<\/p>\n","protected":false},"author":1,"featured_media":2409,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-2408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/posts\/2408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/comments?post=2408"}],"version-history":[{"count":4,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/posts\/2408\/revisions"}],"predecessor-version":[{"id":2422,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/posts\/2408\/revisions\/2422"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/media\/2409"}],"wp:attachment":[{"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/media?parent=2408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/categories?post=2408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unioviedo.es\/gelp\/wp-json\/wp\/v2\/tags?post=2408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}