Head and Neck Cancer

GROUP HEAD BIOGRAPHY

Juan Pablo Rodrigo Tapia (Guadalajara, 1966) graduated in Medicine from the University of Oviedo (1989), obtaining the End of Career Award. Between 1991-1994 he specialized in Otorhinolaryngology at the HUCA and spent 3 months at the UCLA School of Medicine (CA, USA). In 1995 he obtained his Doctorate in Medicine from the University of Oviedo. He has worked as Otorhinolaryngologist in the hospitals of León (1995-1998) and HUCA (1998-2008). In 2008 he obtained the position of Associate Professor of Otorhinolaryngology at the University of Oviedo-HUCA, and in 2016 the position of Professor. He is Director of the Department of Surgery and Medical-Surgical Specialties, member of the International Head and Neck Scientific Group. Author of more than 300 scientific publications, he has an H-index of 45, being included in the ranking “Top 2% scientists” of Stanford University in 2021 and is ranked among the top 10 laryngeal cancer experts in the world.

https://orcid.org/0000-0003-3063-0890

SELECTED PUBLICATIONS

• Sanchez-Canteli M, Granda-Díaz R, Del Rio-Ibisate N, Allonca E, López-Alvarez F, Agorreta J, Garmendia I, Montuenga LM, García-Pedrero JM, Rodrigo JP. PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas. Cancer Immunol Immunother. 2020 May 24. doi: 10.1007/s00262-020-02604-w.
• Riobello C, López-Hernández A, Cabal VN, García-Marín R, Suárez-Fernández L, Sánchez-Fernández P, Vivanco B, Blanco V, López F, Franchi A, Llorente JL, Hermsen MA. IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management. Am J Surg Pathol. 2020 Mar;44(3):396-405. doi: 10.1097/PAS.0000000000001420.
• Lorenzo-Martín LF, Fernández-Parejo N, Menacho-Márquez M, Rodríguez-Fdez S, Robles-Valero J, Zumalave S, Fabbiano S, Pascual G, García-Pedrero JM, Abad A, García-Macías MC, González N, Lorenzano-Menna P, Pavón MA, González-Sarmiento R, Segrelles C, Paramio JM, Tubío JMC, Rodrigo JP, Benitah SA, Cuadrado M, Bustelo XR. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020 Sep 22;11(1):4788. doi: 10.1038/s41467-020-18524-3.
• Garmendia I, Pajares MJ, Hermida-Prado F, Ajona D, Bértolo C, Sainz C, Lavín A, Remírez AB, Valencia K, Moreno H, Ferrer I, Behrens C, Cuadrado M, Paz-Ares L,Bustelo XR, Gil-Bazo I, Alameda D, Lecanda F, Calvo A, Felip E, Sánchez-CéspedesM, Wistuba II, Granda-Diaz R, Rodrigo JP, García-Pedrero JM, Pio R, Montuenga LM,Agorreta J. YES1 Drives Lung Cancer Growth and Progression and PredictsSensitivity to Dasatinib. Am J Respir Crit Care Med. 2019 Oct 1;200(7):888-899.doi: 10.1164/rccm.201807-1292OC.
• Hermsen MA, Riobello C, García-Marín R, Cabal VN, Suárez-Fernández L, López F,Llorente JL. Translational genomics of sinonasal cancers. Semin Cancer Biol. 2019Sep 24. pii: S1044-579X(19)30306-2. doi: 10.1016/j.semcancer.2019.09.016.
• Hermida-Prado F, Granda-Díaz R, Del-Río-Ibisate N, Villaronga MÁ, Allonca E, Garmendia I, Montuenga LM, Rodríguez R, Vallina A, Alvarez-Marcos C, Rodrigo JP, García-Pedrero JM. The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2019 Oct 25;11(11):1644. doi: 10.3390/cancers11111644.
• Bernardo-Castiñeira C, Valdés N, Celada L, Martinez ASJ, Sáenz-de-Santa-MaríaI, Bayón GF, Fernández AF, Sierra MI, Fraga MF, Astudillo A, Jiménez-Fonseca P,Rial JC, Hevia MÁ, Turienzo E, Bernardo C, Forga L, Tena I, Molina-Garrido MJ,Cacho L, Villabona C, Serrano T, Scola B, Chirivella I, Del Olmo M, Menéndez CL, Navarro E, Tous M, Vallejo A, Athimulam S, Bancos I, Suarez C, Chiara MD.Epigenetic Deregulation of Protocadherin PCDHGC3 inPheochromocytomas/Paragangliomas Associated With SDHB Mutations. J ClinEndocrinol Metab. 2019 Nov 1;104(11):5673-5692. doi: 10.1210/jc.2018-01471.
• Bernardo-Castiñeira C, Valdés N, Sierra MI, Sáenz-de-Santa-María I, Bayón GF, Perez RF, Fernández AF, Fraga MF, Astudillo A, Menéndez R, Fernández B, Del Olmo M, Suarez C, Chiara MD. SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas. J Clin Endocrinol Metab. 2018 Jan 1;103(1):295-305. doi: 10.1210/jc.2017-01702.
• Llanos S, García-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M. Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438
• Llorente JL, López F, Suárez C, Hermsen MA.Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances. Nat Rev Clin Oncol. 2014;11:460-72.