Carlos López Otín

Departament of Biochemistry and Molecular Biology. Santiago Gascón building.


The research performed by Carlos López-Otín’s group is organized around three main lines:

Lab web page


for more than 25 years, Carlos Lopez-Otin focused on the study of the involvement of proteolytic systems in pathological processes, especially in cancer. His group has identified more than 60 novel human proteases and they have also proposed a global approach for the study of proteases in health and disease through novel concepts such as Degradomics and Degradome. In parallel studies, the Lopez-Otin group has been involved in the functional annotation of the human genome and other genomes and degradomes of biomedical and evolutionary relevance, from chimpanzees and other primates to mice and whales.

Cancer Genomics:

Since 2009, Carlos Lopez-Otin co-directs the Spanish contribution to the International Cancer Genome Consortium (ICGC-CLL). This scientific work has led to the unveiling of the complete tumor genome sequence of hundreds of patients with Chronic Lymphocytic Leukemia and to the identification of recurrent mutations in several genes, which have become preferential targets for therapeutic intervention. Closely related to the Cancer Genome projects, Lopez-Otin’s group has discovered two new genes implicated in the progression of head and neck carcinomas, and they have identified the genetic determinants of several hereditary diseases: sudden death, microcytic anemia, bone abnormalities, familial melanoma and two novel premature aging syndromes.


Lopez-Otin’s group has reported the first integrative analysis of the molecular and cellular hallmarks of aging and proposed different strategies for the metabolic control of longevity. Moreover, they have recently developed a method to facilitate the cell reprogramming of aged human cells to pluripotent cells with embryonic properties. The Lopez-Otin group has identified a new loss-of-proteostasis mechanism of myeloid transformation, connecting age-associated alterations in hematopoietic stem cells with the pathogenesis of hematological malignancies. Finally, they have unveiled the molecular mechanisms underlying different syndromes of premature aging and in collaboration with Nicolas Levy’s group, they have developed therapeutic strategies for the treatment of Hutchinson-Gilford progeria syndrome (HGPS).


Carlos Lopez-Otin is a Professor of Biochemistry and Molecular Biology, combining his teaching responsibilities with his research lines: Cancer, Aging Biology and Functional Analysis of Genomes. He has published over 400 articles and have been cited more than 50.000 times, with an aggregate Hirsch index of h=106. He is a member of numerous journal editorial boards, committees, and scientific societies, including the Spanish Royal Academy of Sciences and the European Academy. Throughout his scientific career, he has received national and international awards and distinctions, including the Doctorates “Honoris Causa” from the International University Menendez Pelayo, the University of Zaragoza and the Autonomous University of Chile, the “Rey Jaime I” Award in Research, the European “25th FEBS Jubilee” Award in Biochemistry, the Mexico Award in Science and Technology, and the “Santiago Ramón y Cajal” National Research Award. In 2017, he was awarded an “ERC Advanced Grant” from the European Union.


  • Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E. “Non-coding recurrent mutations in chronic lymphocytic leukaemia”Nature526: 519-524 (2015)
  • Osorio FG, Soria-Valles C, Santiago-Fernández O, Bernal T, Mittelbrunn M, Colado E, Rodríguez F, Bonzon-Kulichenko E, Vázquez J, Porta-de-la-Riva M, Cerón J, Fueyo A, Li J, Green AR, Freije JM, López-Otín C. “Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling” Nature Med. 22: 91-96 (2016)
  • López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. “Metabolic control of longevity” Cell 166: 802-821 (2016)
  • Ferrando AA, López-Otín C. “Clonal evolution in leukemia” Nature Med. 23: 1135-1145 (2017)
  • Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C. “Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome” Nature Med. 25: 423-426 (2019)
  • Bárcena C, Valdés-Mas R, Mayoral P, Garabaya C, Durand S, Rodríguez F, Fernández-García MT, Salazar N, Nogacka AM, Garatachea N, Bossut N, Aprahamian F, Lucia A, Kroemer G, Freije JMP, Quirós PM, López-Otín C. “Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice” Nature Med. 25: 1234-1242 (2019)
  • Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E, Stein LD. “The U1 spliceosomal RNA is recurrently mutated in multiple cancers” Nature 574: 712-716 (2019)
  • ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (including Puente XS and López-Otín C, Universidad de Oviedo) “Pan-cancer analysis of whole genomes” Nature 578: 82-93 (2020)
  • López-Otín C and Kroemer G. “The hallmarks of health” Cell 184: 33-63 (2021)
  • Bousquets-Muñoz P, Díaz-Navarro A, Nadeu F, Sánchez-Pitiot A, López-Tamargo S, Shuai S, Balbín M, Tubio JMC, Beà S, Martin-Subero JI, Gutiérrez-Fernández A, Stein LD, Campo E, Puente XS. “PanCancer analysis of somatic mutations in repetitive regions reveals recurrent mutations in snRNA U2” NPJ Genom Med. 7:19 (2022)


Nombre Cargo E-mail Teléfono
Carlos López Otín Jefe de grupo clo@uniovi.es 985104201
Antonio Fueyo Silva Investigador fueyos@uniovi.es 985103576
Jose María Pérez Freije Investigador jmpf@uniovi.es 985106281
Xosé Antón Suárez Puente Investigador xspuente@uniovi.es 985105027
Víctor Quesada Fernández Investigador quesadavictor@uniovi.es 985103568
Ana Gutiérrez Fernández Investigadora anaguti@uniovi.es 985103566
Alejandro López Soto Investigador lopezsalejandro@uniovi.es 985109594
David Rodríguez Martínez Investigador rodriguezdavid@uniovi.es 985106231
Alejandro Piñeiro Ugalde Investigador Ramón y Cajal pineiroalejandro@uniovi.es 985102706
Alicia Rodríguez Folgueras Investigadora arfolgueras@uniovi.es 985106283
Gabriel Bretones Sánchez Contratado Post-doctoral bretonesgabriel@uniovi.es 985102747
Magda Rita Hamczyk Contratada Post-doctoral hamczykmagda.uo@uniovi.es 985105025
Yaiza Español Fernández Lab-manager espanolyaiza@uniovi.es 985105025
Cecilia Garabaya Fernández Técnica de laboratorio ceciliag@uniovi.es 985105025
Sonsoles Álvarez Miranda Técnica de laboratorio sonsoles@uniovi.es 985102747
Diana Álvarez Puente Técnica de laboratorio alvarezdiana@uniovi.es 985104202
Alejandra Valle Cao Contratada Predoctoral alevallecao@gmail.com 985102747
Cristina Olivares Fernández Contratada Predoctoral cristinaof.clm@gmail.com 985109573
Javier Rodríguez Arango Contratado Predoctoral rodriguezajavier@uniovi.es 985105025
Daniel Maeso Miguel Contratado Predoctoral maesodani@gmail.com 985102747
Pablo Bousquets Muñoz Contratado Predoctoral bousquetspablo@uniovi.es 985109573
David Roiz del Valle Contratado Predoctoral droiva@gmail.com 985104202
Sara López Tamargo Contratada Predoctoral saralopeztamargo_@outlook.com 985109573
Diego Quintana Torres Contratado Predoctoral diegoqntn@gmail.com 985102747
Javier Fernández Mateos Contratado Post-doctoral fernandezmjavier.uo@uniovi.es 985109573
Lucas Moledo Nodar Contratado Predoctoral lucasmoledonodar@gmail.com 985105025
Mª Asunción Morchón Solis Personal administrativo susina@uniovi.es 985102706
Clea Bárcena Fernández Investigadora Ramón y Cajal barcenaclea@uniovi.es 985103567
Raquel Capín Pérez Graduada capinraquel@outlook.com 985105034