Guillermo M Albaiceta

Avda. de Roma S/N. Edificio FINBA. HUCA. Planta 1. Laboratorio 19. 33011. Oviedo.


Injury and repair mechanisms of pulmonary parenchyma.
Pulmonary injury in critical oncological patient.
Critical ill patient monitoring.

1 .Injury and repair mechanisms of pulmonary parenchyma.

The main aim of this work line is the characterization of the molecular mechanisms involved in acute lung injury and its repair, to identify new therapeutic alternatives. Several research strategies in animal and cell models, analysis with patients and development of ex-vivo assays with human samples are carried out.

This work line includes different projects: Mechanotransduction mechanisms of the nuclear membrane; Pulmonary repair in influenza A virus (H1N1) patients; Tolerance induction to mechanical ventilation; Role of MMP-14 in lung injury secondary to sepsis; Ventilation induced brain injury.

2. Pulmonary injury in critical oncological patient.

Patients with neoplasias are one of the main subgroups in the development of acute lung injury. What is more, its presence worsen the prognosis significantly when mechanical ventilation is required for the treatment of lung injury. Among oncological patients that required ICU treatments, patients with haematological neoplasias are the most gravity group.

This research line tries to identify specific pathogenic mechanisms responsible for the injury of oncological patients subject to mechanical ventilation. The projects included in this line are: Mechanical ventilation in presence of neoplasias; pulmonary injury and repair in critical haematological patients; Aging, ventilator induced lung injury and lung repair.

3. Critical ill patient monitoring.

The identification of parameters, which allow treatment or diagnosis adjustment, is the main goal of this line. The projects included in this part are the next: Respiratory mechanics monitoring; Role of MMP-14 in sepsis.

The diversity showed in this field point the translational vocation of the group, taking to the laboratory research questions emerged in the clinical sphere and testing in the clinical practise the laboratory discoveries.


Guillermo Muñiz Albaiceta was born in Pamplona in 1973. He got the medical degree at Oviedo University, where he started his research activity. He made a fellowship in Intensive Medicine at Hospital Universitario Central de Asturias (Oviedo), where, in 2003, he started to work as attending physician. From 2015 he is the head of the Cardiac Critical Care Unit.

He obtains his MSc degree in 2002. In addition, this year he made a short stay in the Centro de Cirugía Experimental del Hospital de Sabadell (Consorcio Hospitalario Parc Taulí). In Sabadell he collaborated with Dr. Lluis Blanch research group in several projects. In 2006 he obtained his PhD under the direction of Francisco Taboada. After that, he worked at the Biochemistry Department under Carlos López Otín supervision. In 2009 he set up his own laboratory at Functional Biology Department at Oviedo University. Since 2004 he is maintaining an uninterrupted funding with regional and national projects, which include collaborations with biomedical companies. Since 2009 is associated teacher and until now he has supervised 8 research projects and 3 PhD thesis. His curriculum vitae includes 44 scientific publications and the collaboration as speaker in national and international conferences. He has been honored with several awards from the ATS (American Thoracic Society) and from the SEMICYUC (Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias).


  • Amado-Rodríguez L, Salgado Del Riego E, Gomez de Ona J, López Alonso I, Gil-Pena H, López-Martínez C, Martín-Vicente P, Lopez-Vazquez A, Gonzalez Lopez A, Cuesta-Llavona E, Rodriguez-Garcia R, Boga JA, Elena Alvarez-Arguelles M, Mayordomo-Colunga J, Vidal-Castineira JR, Crespo I, Fernandez M, Criado L, Salvadores V, Jimeno-Demuth FJ, Blanch L, Prieto B, Fernandez-Fernandez A, Lopez-Larrea C, Coto E, Albaiceta GM. Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study. Elife. 2022 Jan 21;11:e73012. doi: 10.7554/eLife.73012.
  • López-Alonso I, López-Martínez C, Martín-Vicente P, Amado-Rodríguez L, González-López A, Mayordomo-Colunga J, Del Busto C, Bernal M, Crespo I, Astudillo A, Arias-Guillén M, Fueyo A, Almendros I, Otero J, Sanz-Fraile H, Farré R, Albaiceta GM. Mechanical ventilation promotes lung tumor spread by modulation of cholesterol cell content. Eur Respir J. 2021 Dec 9:2101470. doi: 10.1183/13993003.01470-2021.
  • Amado-Rodríguez L, Del Busto C, López-Alonso I, Parra D, Mayordomo-Colunga J, Arias-Guillén M, Albillos-Almaraz R, Martín-Vicente P, López-Martínez C, Huidobro C, Camporota L, Slutsky AS, Albaiceta GM. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial. Ann Intensive Care. 2021 Aug 28;11(1):132. doi: 10.1186/s13613-021-00919-0.
  • Blázquez-Prieto J, Huidobro C, López-Alonso I, Amado-Rodriguez L, Martín-Vicente P, López-Martínez C, Crespo I, Pantoja C, Fernandez-Marcos PJ, Serrano M, Sznajder JI, Albaiceta GM. Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation. Transl Res. 2021 Jul;233:104-116. doi: 10.1016/j.trsl.2021.01.008.
  • López-Alonso I, Blázquez-Prieto J, Amado-Rodríguez L, González-López A, Astudillo A, Sánchez M, Huidobro C, López-Martínez C, Dos Santos CC, Albaiceta GM. Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation. Sci Transl Med. 2018 Aug 29;10(456):eaam7598. doi: 10.1126/scitranslmed.aam7598.
  • Blázquez-Prieto J, López-Alonso I, Amado-Rodríguez L, Huidobro C, González-López A, Kuebler WM, Albaiceta GM. Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9. Thorax. 2018 Apr;73(4):321-330. doi: 10.1136/thoraxjnl-2017-210105.
  • Amado-Rodríguez L, Bernal T, López-Alonso I, Blázquez-Prieto J, García-Prieto E, Albaiceta GM. Impact of Initial Ventilatory Strategy in Hematological Patients With Acute Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med. 2016 Jul;44(7):1406-13. doi: 10.1097/CCM.0000000000001613.
  • González-López A, López-Alonso I, Aguirre A, Amado-Rodríguez L, Batalla-Solís E, Astudillo A, Tomás-Zapico C, Fueyo A, dos Santos CC, Talbot K, Albaiceta GM. Mechanical ventilation triggers hippocampal apoptosis by vagal and dopaminergic pathways. Am J Respir Crit Care Med. 2013 Sep 15;188(6):693-702. doi: 10.1164/rccm.201304-0691OC.


Nombre Cargo E-mail Teléfono
Guillermo Muñiz Albaiceta Jefe de grupo gma@lab14.org 985102713
Laura Amado Rodríguez Medico facultativo especialista de área/ Investigadora lar@lab14.org
Raquel María Rodríguez García Medico facultativo especialista de área/ Investigadora
Adrián González López Investigador agl@lab14.org
Inés López Alonso Profesora Universidad de Oviedo/ Investigador ila@lab14.org
Irene Crespo Gómez Profesora Universidad de Oviedo/ Investigador
Cecilia López Martínez Contratada predoctoral
Emilio García Prieto Medico facultativo especialista de área/Investigador
Paula Martín Vicente Contratada predoctoral
Margarita Fernández Rodríguez Técnico de laboratorio