Publications 2008-2015

  • Dmitry F. Zamyatkin, Francisco Parra, José M. Martín Alonso, Daniel A. Harki, Blake R. Peterson, Pawel Grochulski and Kenneth K.-S. Ng. (2008). Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J. Biol. Chem. 283: 7705-7712.
  • Christoph Rademacher, N. Rama Krishna, Monica Palcic, Francisco Parra, and Thomas Peters. (2008). NMR Experiments Reveal the Molecular Basis of Receptor Recognition by a Calicivirus. J. Am. Chem. Soc. 130: 3669-3675.
  • Rosa Casais, Lorenzo González Molleda, Angeles Machín, Gloria del Barrio, Alberto García Manso, Kevin P. Dalton, Ana Coto, José Manuel Martín Alonso, Miguel Prieto, Francisco Parra. (2008). Structural and functional analysis of virus factories purified from Rabbit vesivirus-infected Vero cells. Virus. Res. 137: 112-121.
  • Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA. (2008). The Fasciola hepatica thioredoxin: high resolution structure reveals two oxidation states. Mol. Biochem. Parasitol. 161:44-48.
  • del Barrio Alonso, G., Alvarez Rodriguez, A. L., Valdés Garcia, S.M., Parra Fernandez, F. (2008). Methodology for the preclinical screening of anti-herpesvirus activity starting from natural products. Revista Cubana de Farmacia. 42(2): 1-10.
  • Farnos,O.; Fernandez,E.; Chiong,M.; Parra,F.; Joglar,M.; Mendez,L.; Rodriguez,E.; Moya,G.; Rodriguez,D.; Lleonart,R.; Gonzalez,E.M.; Alonso,A.; Alfonso,P.; Suarez,M.; Rodriguez,M.P.; Toledo,J.R. (2009). Biochemical and structural characterization of RHDV capsid protein variants produced in Pichia pastoris: Advantages for immunization strategies and vaccine implementation. Antivir. Res. 81: 25-36.
  • Balseiro, A., Dalton, K.P., del Cerro, A., Marquez, I., Cunningham, A.A., Parra, F., Prieto, J.M. and Casais, R. (2009). Pathology, isolation and molecular characterisation of a ranavirus from the common midwife toad Alytes obstetricans on the Iberian Peninsula. Dis. Aquat. Org. 84: 95-104.
  • Machín A, Martín Alonso JM, Dalton KP, Parra F. (2009). Functional differences between precursor and mature forms of the RdRp from rabbit hemorrhagic disease virus. J.Gen.Virol. 90: 2114 – 2118.
  • Dmitry F. Zamyatkin, Francisco Parra, Ángeles Machín, Pawel Grochulski and Kenneth K.-S. Ng. (2009). Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces rearrangement of the Active Site. J. Mol. Biol. 390: 10-16.
  • Álvarez, A.L., del Barrio, G., Kourí, V., Álvarez, P.A., Suárez, B. and Parra, F. (2009). In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis. Phytomedicine 16: 960-966.
  • González-Reyes, S., García-Manso, A., del Barrio, G., Dalton, K.P., González-Molleda, L., Arrojo-Fernández, L., Nicieza, I., and Parra. F. (2009). Role of annexin A2 in cellular entry of rabbit vesivirus. J. Gen. Virol 90: 2724 - 2730.
  • Dalton, K.P., Ringleb, F., Martín Alonso, J.M., and Parra, F. (2009). Rapid identification of myxoma virus variants by long-range PCR and restriction fragment length polymorphism analysis. J.Virol.Methods. 161: 284-288.
  • Dalton, K.P., Ringleb, F., Martín Alonso, J.M., and Parra, F. (2009). Rapid purification of Myxoma virus DNA. J.Virol.Methods. 162: 284-287.
  • Belén Suárez, Ángel L. Álvarez, Yolanda Diñeiro García , Gloria del Barrio ,Anna Picinelli Lobo, Francisco Parra (2010). Phenolic profiles, antioxidant activity and in vitro antiviral properties of apple pomace. Food Chemistry. 120: 339-342.
  • Balseiro,A.; Dalton,K.P.; Del,Cerro A.; Marquez,I.; Parra,F.; Prieto,J.M.; Casais,R. (2010). Outbreak of common midwife toad virus in alpine newts (Mesotriton alpestris cyreni) and common midwife toads (Alytes obstetricans) in Northern Spain: A comparative pathological study of an emerging ranavirus. Vet.J 186: 256-258.
  • Dalton,K.P., Nicieza, I., Baragaño, A., Martin Alonso, J.M. and Parra, F. (2010). Molecular characterisation of virulence graded field isolates of myxoma virus. Virology Journal (2010). 7:49.
  • Ng, K.K.S.. and Parra, F. (2010). Calicivirus Protein Structures. In "Caliciviruses. Molecular and Cellular Virology" 1, 95-110. Caiser Academic Press. UK. ISBN: 1904455638.
  • Fernández E, Toledo JR, Chiong M, Parra F, Rodríguez E, Montero C, Méndez L, Capucci L, Farnós O. (2011). Single dose adenovirus vectored vaccine induces a potent and long-lasting immune response against rabbit hemorrhagic disease virus after parenteral or mucosal administration. Vet Immunol Immunopathol. 142(3-4):179-88.
  • Álvarez, A.L., Habtemariam, S., Juan-Badaturuge, M., Jackson, C., Parra, F. (2011). In vitro Anti HSV-1 and HSV-2 Activity of Tanacetum vulgare Extracts and Isolated Compounds: An Approach to their Mechanisms of Action. Phytotherapy Res. 25: 296-301.
  • Christoph Rademacher, Julie Guiard, Pavel I. Kitov, Brigitte Fiege, Kevin P. Dalton, Francisco Parra, David R. Bundle, Thomas Peters. (2011). Targeting Norovirus Infection – Multivalent Entry Inhibitor Design Based on NMR Experiments. Chemistry. 17, 7442-7453.
  • Gloria del Barrio, Iraida Spengler, Trina García, Annele Roque, Ángel L. Álvarez, José S. Calderón, Francisco Parra. (2011). Antiviral activity of Ageratina havanensis (Kunth) and major chemical compounds from the most active fraction. Brazilian Journal of Pharmacognosy. 21(5), 915-920.
  • Maggioli, G. ; Silveira, F. ; Martín-Alonso, J.M. ; Salinas, G. ;Carmona, C. ; Parra, F. (2011). A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits. Exp. Parasitol. 129, 323-330.
  • Brigitte Fiege, Christoph Rademacher, Jonathan Cartmell, Pavel I. Kitov, Francisco Parra, and Thomas Peters. (2012). Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as studied by STD NMR Spectroscopy. Angew Chem Int Ed Engl. 51(4):928-32.
  • Álvarez, A.L., Melón, S., Dalton, K.P., Nicieza, I., Roque, A., Suárez, B., Parra, F. (2012) Apple pomace, a by-product from the Asturias cider industry, inhibits HSV-1 and HSV-2 in vitro replication: a mechanistic approach to its modes of action. Journal of Medicinal Food. 15(6):581-587.
  • del Barrio, G. and Parra, F. (2012). Antiviral Activities of Phyllanthus orbicularis, an Endemic Cuban Species. In "Traditional Herbal Medicines for Modern Times. Phyllanthus Species. Scientific Evaluation and Medicinal Applications". 10, 219-233. CRC Press. ISBN: 978-1-4398-2144-2.
  • Álvarez, A.L., Dalton, K.P., Nicieza, I., Diñeiro, Y., Picinelli, A., Melón, S., Roque, A., Suárez, B., Parra, F. (2012). Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds.Phytotherapy Research. 26(10):1513-20.
  • K.P. Dalton, I. Nicieza, A. Balseiro, M. Muguerza, J.M. Rosell, R. Casais, Á.L. Álvarez, and F. Parra. (2012). Variant Rabbit Hemorrhagic Disease Virus in Young Rabbits, Spain. Emerg. Infect. Dis. 18(12):2009-12
  • Erlinda Fernández, Jorge R Toledo, Lídice Méndez, Nemecio González, Francisco Parra, José M Martín-Alonso, Miladys Limonta, Kosara Sánchez, Ania Cabrales, Mario P Estrada, Alina Rodríguez-Mallón, Omar Farnós. (2013) Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose vaccine. PLoS ONE 8(2):e56417.
  • Marta Bally, Moritz Graule, Francisco Parra, Göran Larson, Fredrik Höök. (2013) A virus biosensor with single virus-particle sensitivity based on fluorescent vesicle labels and equilibrium fluctuation analysis. Biointerphases. 8(1):4.
  • Joana Abrantes, Ana M Lopes, Kevin P Dalton, Pedro Melo, Jorge J Correia, Margarida Ramada, Paulo C Alves, Francisco Parra, Pedro J Esteves. (2013) New Variant of Rabbit Hemorrhagic Disease Virus, Portugal, 2012-2013. Emerging Infectious Diseases. 19(11):1900-02.
  • Joana Abrantes, Ana M Lopes, Kevin P Dalton, Francisco Parra, Pedro J Esteves. (2014) Detection of RHDVa on the Iberian Peninsula: isolation of an RHDVa strain from a Spanish rabbitry.. Archives of Virology. 159(2): 321-326.
  • Kevin P Dalton, Inés Nicieza, Joana Abrantes, Pedro J Esteves, Francisco Parra. (2014) Spread of new variant RHDV in domestic rabbits on the Iberian Peninsula.. Veterinary Microbiology. 169(1-2):67-73.
  • Casais R, Dalton KP, Millán J, Balseiro A, Oleaga A, Solano P, Goyache F, Prieto JM, Parra F. (2014) Primary and secondary experimental infestation of rabbits (Oryctolagus cuniculus) with Sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation. Vet Parasitol. 203(1-2):173-83.
  • Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK. (2014) Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr D Biol Crystallogr. 1;70(Pt 12):3099-109
  • Lopes AM, Dalton KP, Magalhães MJ, Parra F, Esteves PJ, Holmes EC, Abrantes J. (2015) Full genomic analysis of new variant rabbit hemorrhagic disease virus revealed multiple recombination events. J Gen Virol. 96(Pt 6):1309-19.
  • Fernández E, Toledo JR, Mansur M, Sánchez O, Gil DF, González-González Y, Lamazares E, Fernández Y, Parra F, Farnós O. (2015) Secretion and assembly of calicivirus-like particles in high-cell-density yeast fermentations: strategies based on a recombinant non-specific BPTI-Kunitz-type protease inhibitor. Appl Microbiol Biotechnol. 99(9):3875-86.
  • Dalton KP, Abrantes J, Lopes AM, Nicieza I, Álvarez ÁL, Esteves PJ, Parra F. (2015) Complete genome sequence of two rabbit hemorrhagic disease virus variant b isolates detected on the Iberian Peninsula. Arch Virol. 160(3):877-81.
  • Dalton KP, Nicieza I, de Llano D, Gullón J, Inza M, Petralanda M, Arroita Z, Parra F. (2015) Vaccine breaks: Outbreaks of myxomatosis on Spanish commercial rabbit farms. Vet Microbiol. 5;178(3-4):208-16.
  • Álvarez ÁL, Habtemariam S, Parra F. (2015) Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication. Nat Prod Res. 12:1-6.
  • Álvarez ÁL, Habtemariam S, Abdel Moneim AE, Melón S, Dalton KP, Parra F. (2015) A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells. Antiviral Res. 119:8-18.



Departamento de Bioquímica y Biología Molecular
Instituto Universitario de Biotecnología de Asturias
Edificio Santiago Gascón
Campus El Cristo. Universidad de Oviedo
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