PhD Thesis (Dissertation Thesis)Master ThesisHabilitation ThesisBachelor Thesis

Aptamers as analytical tools in clinical diagnosis: selection, characterization and applications

July 18, 2022

Detection of prostate cancer-related glycosylation changes in PSA: selection of aptamers and design of electrochemical aptasensors

December 18, 2020

Traceability of genetically modified organisms in the food chain: Development of biosensing devices as new approaches for their detection

July 26, 2018

Electrochemical devices for pathogen detection based on helicase-dependent isothermal DNA amplification

July 24, 2017

Electrochemical DNA biosensors and sensing platforms for the detection and quantification of genetically modified soybean in food and feed

April, 2017
International PhD

Development of sensing phases for the detection of tumoral markes with electrochemical and optical sensors

Dec 1, 2015
International PhD

Indirect determination of gluten through methods based in ADN detection: PCR and electrochemical genosensors

Oct 15, 2015
European PhD

Selection of aptamers against allergenic proteins of gluten and application to electrochemical assays

May 8, 2015
European PhD

Structured nucleic acids as affinity receptors for the design of electrochemical sensors

Nov 22, 2012
International PhD

Quinoid compounds adsorption on nanocrystalline Pt surfaces: novel spectroelectroanalytical molecular probes

July 20, 2011

Development of molecularly imprinted polymers with chloroperoxidase biomimetic activity

May 28, 2010

Electrochemical DNA sensors for the detection of Legionella pneumophila

Sep 25, 2009
European PhD

Computational design of affinity receptors based on molecularly imprinted polymers for electrochemical sensors

December 1, 2008

Synthesis and evaluation of artificial receptors artificiales for diclofenac based on molecular imprinted technology

February 1, 2008
European PhD

Voltammetric detection of rifampicin with molecularly imprinted polymers

May 2003

Electrocatalytic detection of NADH and DNA specific sequences of pathogens

February 15, 2003

Electrocatalytic detection of adenine derivatives

June 21, 2002

Amperometric sensors based on carbon electrodes modified with peroxidase

Nov 1997

Amperometric biosensors based on NAD+/NADH-dependent dehydrogenases

Extraordinary Award

Electroanalytical behavior of buprenorphine and its applications to the development of novel pharmaceutical and biomedical methods.


Surfactant-sensitized voltammetry for methotrexate and uric acid in biological samples


Adsorption-stripping voltammetry on mercury coating electrodes and microelectrodes. Applications to flow systems


Adsorption/stripping voltammetric techniques applied to the analysis of sodium 2-mercaptoethanosulfonate and mitoxantrone

Extraordinary Award

Study and electroanalytical applications of some biologically relevant pteridines


Implementation and validation of a method of determination of fluoride in drinking water according to the UNE-EN ISO/IEC 17025 standard

July 2022

Characterization of aptamers against components of tumour extracellular matrix

July 2022

Evaluation of circulating lncRNAs as diagnostic biomarkers for the detection of colorectal cancer

July 2022

Selection of aptamers against BCMA, a novel biomarker for multiple myeloma

July 2022

Development of electrochemical genosensors for the detection of long noncodingRNA overexpressed in prostate cancer

July 2020

Anti-PSA aptamers as potential modifiers of the proteolytic activity

July 2020

Selective capture of hydrolyzed gluten in food using aptamers as a bait

July 2020

Design and validation of a method to determine nitrites in drinking water according to the ISO17025 standard in an agro-food laboratory

July 2020

Digestión gastrointestinal de gliadina: captura de péptidos con aptámeros e identificación por LC-ESI-MSMS

July 2020

Employment of commercial glucose meters (glucometers) for the detection of DNA

July 22, 2019

Ultrasensitive detection of cancer biomarkers in serum

February 4, 2019

Innovative strategies for cancer biomakers detection in blood

July 20, 2017

Modification of anti-gluten aptamers: effect on their binding characteristics

July 19, 2017

Electrochemical sensors based on nucleic acid for the detection of microbial contaminants in food

July 10, 2017

Desarrollo de un sensor electroquímico para el diagnóstico no invasivo del cáncer de páncreas

July 10, 2017

Design and optimization of sensing phases for the electrochemical detection of DNA of pathogenic bacteria

July 21, 2016

Multivalent aptamers: novel receptors to improve the sensitivity of gluten detection

July 21, 2016

Ag nanoparticles as markers for electrochemical genoassays: detection of genetically modified organism (GMOs)

July, 2015

Molecular recognition of immunotoxic peptides from gluten with aptamers

July, 2015

Development of bioelectroanalytical methods based on the use of liposomes as carriers of redox markers

July, 2015

Innovative assay formats for the food safety control: determination of gluten in food

May, 2015

Aptassay with spectrophtometric detection for gluten quantitation

July 8, 2014

Development of an electrochemical genosensor for the detection of the 16S rRNA gen from Legionella pneumophila

July 3, 2014

Rapid detection of Micobacterium tuberculosis through an electrochemical genoassay

July 23, 2013

Towards an electrochemical aptamer-based assay for gluten detection

July 22, 2013

Development of an electrochemical genoassay for Salmonella detection

July 23, 2012

Electrochemical detection of Escherichia Coli O157:H7 using its genetic material

July 23, 2012

Development of a genomagnetic assay for the detection of Mycobacterium Tuberculosis

July 21, 2011

Electrochemical and catalytic oxidation of 5-hydroxyindolacetic acid

Sept 2010

Development of an amperometric flow injection method for the detection of gliadin

July 2010

Molecular recognition of tobramycin using modified ARN aptamers and detection by SPR and faradaic impedance spectroscopy

June 2009

Genosensor for the amplified electrochemical detection of specífic DNA sequences of L. pneumophila

September 2006

Biomimetic receptors of chloroperoxidases for the dehalogenation of 2,4,6-trichlorophenol

September 2006

Voltammetric study of diclofenac and its sorption equilibrium in molecularly imprinted polymers

June 1, 2004

Correlation between ab initio predictions and experimental affinity distributions in the design of molecularly imprinted polymers

June 1, 2004

Electrogenerated polyphenol-modified electrodes for the detection of dopamine

June 1, 2004

Electrocatalytic detection of hybridization in short DNA sequences

Sept 24, 2001

Electrodes modified with imprinted polyphosphazenes for the detection of rifamycin SV

Sept 25, 2000

Voltammetric detection of adenine homopolynucleotides at carbon electrodes

July 4, 2000

Amperometric detection of serum activity of lactate dehydrogenase with ADP-modified electrodes

Sept 30, 1999

Characterization of specific aptamers against allergenic protein of wheat, gliadin: Determination of the affinity constant

June 23, 2014

Development of a new sensing phase for the electrochemical detection of Salmonella

June 2013

Convergent electrochemical oxidation of guanosine and xanthosine

Nov 2007
Extraordinary Award

Structured DNA probes for the amperometric detection of specific sequences of Legionella Pneumophila

Nov 2005
Extraordinary Award

Influence of cationic tensioactive on the voltammetric behavior of flufenamic acid on carbon paste electrodes

Nov 2003

Ab-initio calculation for the rational design of molecularly imprinted polymers. Application to the development of a sensor for homovanillic acid

Nov 2003

MnO2 as electron mediator on carbon paste and screen printed electrodes. Application to the determination of H2O2 and glucose

Nov 2002

Adsorption voltammetry of rifampicin on carbon paste electrodes

Nov 2001
Extraordinary Award

ATP-modified electrodes for the electrocatalytic detection of NADH and the amperometric determination of the activity of isocitrate dehydrogenase

Nov 2000
Extraordinary Award

5′-polyadenilic acid-modified electrodes for the detection of NADH

Nov 2000
Extraordinary Award

Electrocatalytic detection of NADH on adenosine-modified graphite electrodes

June 2000

Electrocatalytic detection of NADH and ethanol on AMP-modified graphite electrodes

July, 1999

ADP-modified electrodes for the electrocatalytic detection of NADH in solution

Nov 27, 1998
Extraordinary Award

Electrocatalytic detection of NADH and glycerol on NAD+-modified carbon electrodes

Nov, 1997

Design and evaluation of a amperometric biosensor for glutamate

Nov, 1996

Poly-o-aminophenol as electrode material for a hydrogen peroxide biosensor

Nov, 1994

Critical Review on aptamer applications against viruses

Supervisors: Prof. F. Parra, Prof. M.J. Lobo Castañón
July 2020

Determination of parabens in cosmetics

Supervisor: Dr. Rebeca Miranda Castro
January 2020

Detection of protein biomarkers of pancreatic cancer through aptamer-based assays

Supervisor: Dr. Rebeca Miranda Castro
July 2021

Detection of gluten using innovative biosensors to improve the food safety

Supervisors: Dr. Noemí de los Santos Álvarez, Dr. Rebeca Miranda Castro
July 2018

Salmonella surveillance in food using a sensing platform based on its genetic material

Supervisors: Prof. María Jesús Lobo Castañón, Dr. Rebeca Miranda Castro
July 2017

Design of a rapid system of Legionella pneumophila detection with electrochemical biosensors

Supervisor: Prof. María Jesús Lobo Castañón
June 2013

Novel tools for the prostate cancer diagnosis and monitoring based on aptamers

Supervisors: Dr. Rebeca Miranda Castro, MSc. Ramón Lorenzo Gómez
July 2019

Prostate specific antigen (PSA) detection using aptamers

Supervisors: Dr. Rebeca Miranda Castro, MSc. Ana Díaz Fernández
July 2019

Strategies of isothermal amplification combined with aptasensors: Application to cancer biomarkers detection

Supervisor: Dr. Rebeca Miranda Castro
February 2020